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Zoonotic Diseases
ze plague
63
Accounting
Pre-School
02/25/2009

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Cards

Term
Area endemic to the plague
Definition
Western US
Term
Sylvatic plague
Definition
rodent-to-rodent transmission (rural/wild)
Term
Urban plague
Definition
rat-to-rat via flea
Term
bubonic plague
Definition
sylvatic or urban plague transferred by infected fleas
Term
Pneumonic plague
Definition
bacteremic spread to lungs via droplet spread
Term
YopH
Definition
Yersinia pestis virulence factor; disrupts actin filaments
Term
YopE
Definition
Y. pestis virulence factor: depolymerizes actin microfilaments
Term
YopM
Definition
prvents platelet activation through thrombin
Term
pathophysiology of bubonic plague
Definition
portal of entry through skin, bubo forms (enlarged lymph node), bacteremia and metastatic foci
Term
pathophysiology of pneumonic plague
Definition
either metastatic bubo or inhalation from another person
Term
how you get septicemic plague
Definition
direct inoculation of bacteria into blood by flea
Term
flea bite, couple day incubation, rapid spike in temp, a sore at bite site and inflamed lymph node at groin
Definition
Bubonic plague (y. pestis)
Term
short incubation, respiratory problems, fever, dyspnea, death in 2/3 days
Definition
pneumonic plague
Term
bipolar-staining bacilli, pleomorphic, requires AAs
Definition
Yersinia pestis
Term
treatment for the plague
Definition
streptomycin
Term
ticks and deer flies, extremely infective if direct entry, high fever that relapses
Definition
Francisella tularensis
Term
Rabbit fever
Definition
francisella tularensis
Term
ulceroglandular tularemia (clin presentation)
Definition
papule becomes pustular then ulcerates, pneumonia occurs or granuloma
Term
enteric tularemia
Definition
typhoidal tularemia; temp pulse dissociation
Term
pulmonary tularemia
Definition
usually from bacteremia but can be acquired via aerosolization
Term
diagnosis of Francisella tularensis
Definition
serologic tests using sulfhydryl compounds; bacterial agglutination
Term
treatment for fransicella tularensis
Definition
streptomycin
Term
Brucella melitensis
Definition
most invasive, produces severe illness
Term
meat processing plants, undulating fever, long incubation
Definition
Brucella
Term
pathophys of brucella
Definition
penetration, migration to lymph, enter blood circulation, go to organs
Term
host response to brucella
Definition
granuloma formation
Term
acute brucella
Definition
enteric,
Term
localized brucellosis
Definition
females, insidious onset
Term
chronic brucellosis
Definition
mental problems, vague complaints
Term
strain 19 disease
Definition
avirulent B. abortus used for vaccination that causes illness
Term
Lab diagnosis of Brucella
Definition
bone marrow culture, 4-fold rise in titer
Term
small, nonmotile, non spores, aerobic, gram=negative coccobacilli, slow growing
Definition
Brucella spp
Term
Brucella antigen A found on which species
Definition
abortus and suis
Term
antigen M predominates in which species
Definition
brucella melitensis
Term
treatment for brucellosis
Definition
tetracyclin + streptomycin
Term
small, aerobic bacilli, weakly gram neg, obligate intracellular parasites, endocytosed into cell, arthropod vector
Definition
rickettsia, ehrlichia, coxiella
Term
Diagnosis of rickettsia, ehrlichia and coxiella
Definition
Weil-felix reaction + Indirect fluorescence antibody
Term
Rocky mountain spotted fever
Definition
Rickettsia rickettsii
Term
Eastern US vector for rickettia
Definition
dog tick
Term
Western US vector for rickettsia
Definition
wood tick
Term
weeklong incubation, headache, fever, rash after 2 days that begins on wrists/ankles and spreads to trunk within a few hours
Definition
Rickettsia rickettsii
Term
vector for and bacteria of Rickettsialpox
Definition
mite, Rickettsia akari
Term
Initial local lesion --> papulovesicular rash, biphasic infection, severe fever and headaches
Definition
Rickettsia akari
Term
Louse-borne typhus: vectora nd bacteria
Definition
human body louse (man is natural reservoir), Rickettsia prowazekii
Term
headache, fever, maculopapular rash, visited south america/africa
Definition
Rickettsia prowazekii
Term
Vrill-Zinsser disease
Definition
recrudescent epidemic typhus, R. prowazekii
Term
mild epidemic typhus, gulf states, cuased by rat flea
Definition
Murine/endemic typhus = Rickettsia typhi
Term
Q fever
Definition
coxiella burnetii
Term
spore, Australia, sheep, subacute endocarditis
Definition
chronic Q fever: C. burnetii
Term
inhalation of organism, livestock, headache fever, no rash, 3 week incubation
Definition
acute Q fever: Coxiella burnetii
Term
Southeast/southcentral USA, from deer tick, headache, fever, no rash, thrombocytopenia
Definition
Ehrlichia chaffeensis
Term
Monocytic ehrlichiosis
Definition
E. chaffeensis, infects monocytes
Term
granulocytic ehrlichiosis
Definition
not an Ehrlichia spp
Term
similar to rickettsia but NOT an obligate intracellular parasite
Definition
Bartonella spp
Term
Cat scratch disease
Definition
Bartonella henselae
Term
cats, initial pustule, single node adenopathy
Definition
Bartonella henselae
Term
bacillary angiomatosis (creation of new blood cells
Definition
Bartonella henselae
Term
trench fever, human body louse
Definition
Bartonella quintana
Term
smallest free living bacteria, no cell wall
Definition
Mycoplasma
Term
transmission of Mycoplasma
Definition
infected secretions
Term
Young adult, walking pneumonia, insidious onset and slow resolution
Definition
Mycoplasma pneumoniae
Term
Pelvic inflammatory disease, pyelonephritis, postpartum fever
Definition
Mycoplasma hominis
Term
urethritis, cold agglutinins serology
Definition
Ureaplasma urealyticum
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