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Zoonosis
VET 250
142
Veterinary Medicine
Undergraduate 2
02/24/2015

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Cards

Term
How are zoonotic diseases normally transmitted to humans?
Definition
Directly (e.g. contact, bites)
From animal products (e.g. meat)
Vector (e.g. ticks)
Term
What is the rarest type of zoonotic disease transmission?
Definition
Human to human
Term
What is a vector?
Definition
Arthropod or other agent
Term
Transmission depends upon the attributes and requirements of what?
Definition
Pathogen
Vector
Human host
Term
Examples of environmental impact causing emerging diseases
Definition
Deforestation and urbanization
Climate change
Increasing mosquito habitats (retention ponds)
Term
What does Aedes aegypti transmit?
Definition
Yellow Fever and Dengue Fever
Term
Reservoir host
Definition
Domesticated and/or wild animals that harbor a pathogen
Term
Definitive host
Definition
Host in which the parasite reaches sexual maturity
Term
Sentinel
Definition
Non-human organism that can react to an environmental contaminant before the contaminant impacts people
Term
Which species is the sentinel for West Nile Virus?
Definition
Chickens
Term
Seroprevalence
Definition
Number of seropositive individuals in the population
Term
What does a CDC Category A indicate?
Definition
The most severe level of pathogen
Term
What is the Case Fatality Rate?
Definition
Proportion of infected animals that die from a diseasr
Term
What is herd immunity?
Definition
Increased proportion of resistant individuals decreases the susceptible population
Term
What is an epizootic?
Definition
Animal epidemic
Term
Types of prion disease
Definition
BSE
Chronic wasting disease (deer)
Scrapie (sheep/goats)
Creutzfeldt-Jakob Disease
Term
How is rabies transmitted?
Definition
Saliva from an infected animal
Aerosolized bat excrement
Term
CS of rabies in animals
Definition
Behavior changes, paralysis, death
Term
CS of rabies in humans
Definition
Dysphagia, paralysis, nearly 10% death rate in 2-10 days
Term
What kind of pathogen is rabies?
Definition
Lyssavirus
Term
Other names for "Orf"
Definition
Contagious ecthyma
Sore mouth
Term
What kind of pathogen is Orf?
Definition
Poxvirus
Term
How is Orf transmitted?
Definition
Contact with lesions on animal or in the environment
Term
How long do shed Orf lesions remain infectious?
Definition
Years
Term
CS of Orf in humans
Definition
Chicken-pox type lesion on fingers, hands, face, and arms that can last 6 weeks
Term
What kind of pathogen is LCM?
Definition
Arenavirus
Term
What is the reservoir host of LCM?
Definition
Mus musculus
Term
CS of LCM
Definition
Flu-like, can develop meningitis
Term
What kind of pathogen is West Nile Virus?
Definition
Flavivirus
Term
Reservoir host of West Nile Virus
Definition
American robin and house sparrow
Term
Vector of West Nile Virus
Definition
Mosquito (Culex pipiens in IL)
Term
CS of West Nile Virus in humans
Definition
Flu-like symptoms which resolve, persistent fatigue. Can be neuroinvasive, causing encephalitis, meningitis, paralysis, and death
Term
Where was West Nile Virus first reported?
Definition
Uganda
Term
What type of pathogen is Avian flu?
Definition
Influenzavirus A
Term
Reservoir of Avian flu
Definition
Waterfowl and shorebirds
Term
What is antigenic drift?
Definition
Small point mutations
Term
What is antigenic shift?
Definition
Large subtype mutations
Term
Requirements of an epidemic
Definition
1. New emergence in a species with little to no immunity
2. Virus must produce disease in this species
3. Sustainable transmission must occur in new species.
Term
Species most affected by H5N1
Definition
Poultry (100% mortality in 48 hours)
Term
What is the "mixing vessel" of influenza?
Definition
Swine
Term
Which age group had the highest mortality of H5N1?
Definition
10-19 year olds
Term
What type of pathogen is Hantavirus?
Definition
Bunyavirus
Term
What is the reservoir host of Hantavirus?
Definition
Mice (deer mouse in IL)
Term
CS of Hantavirus in humans
Definition
Flulike symptoms with rapid progression to respiratory failure
Term
How is Hantavirus transmitted?
Definition
Aerosol of dried feces, urine, or saliva
Term
What kind of pathogen is Lassa?
Definition
Arenavirus
Term
What is the reservoir host of Lassa?
Definition
NW and OW rats and mice
Term
How is Lassa transmitted?
Definition
Aerosolized virus
Direct contact
Term
What is the most frequently imported arenavirus in the US?
Definition
Lassa
Term
Which zoonoses are bioterrorist threats?
Definition
Lassa
Marburg
Ebola
Anthrax
Q Fever
Brucellosis
Pneumonic plague
Tularemia
Term
What type of pathogen is Marburg?
Definition
Filovirus
Term
Reservoir of Marburg
Definition
Bats (maybe)
Term
Transmission routes of Marburg
Definition
Direct contact, possibly insects
Term
CS of Marburg
Definition
Flu-like, V/D, followed by DIC, thrombocytopenia, and hemorrhage
Term
What type of pathogen is Ebola?
Definition
Filovirus
Term
Transmission routes of Ebola
Definition
Direct contact, possibly insects
Term
CS of Ebola
Definition
Flu-like, V/D, followed by DIC, thrombocytopenia, and hemorrhage
Term
Which subtype of Ebola is most dangerous?
Definition
4th subtype (human-human transmission)
Term
What causes acariasis?
Definition
Sarcoptes scabiei
Term
Which form of TB has a human reservoir host?
Definition
Mycobacterium tuberculosis
Term
What diseases does Mycobacterium avium-intracellulare cause?
Definition
Johne's Disease
Crohns Disease
Term
Transmission methods of Mycobacterium bovis?
Definition
Ingestion of unpasteurized milk
Aerosol
Reverse zoonosis
Term
What is reverse zoonosis?
Definition
Infected human transmits disease to animal
Term
Reservoir host of Mycobacterium avium-intracellulare
Definition
Pretty much everything, including environmental
Term
Transmission methods of leptospirosis
Definition
Contact with infected urine, or through environment
Term
CS of lepto in animals
Definition
Icterus, bloody diarrhea, renal failure
Term
CS of lepto in humans
Definition
Non-specific clinical signs OR multi-organ failure and meningitis.
Term
Vector for Lyme disease
Definition
Deer tick (Ixodes scapularis)
Term
CS of secondary Lyme disease
Definition
Facial nerve palsy, dizziness, syncope, chest pain, palpitations, dyspnea, uveitis, meningitis
Term
How long does a tick need to be attached before transmitting Lyme disease?
Definition
36-48 hours
Term
CS of early Lyme disease
Definition
Fever, myalgia, arthralgia, malaise, headache, stiff neck, lymphadenopathy
Term
CS of late Lyme disease
Definition
Asymmetric arthritis of large joints
May not respond to Abx
Encephalitis
Encephalopathy
Polyneuropathy
Term
Human CS of toxocariasis
Definition
Cough, wheezing
Abdominal pain
Strabismus
Blindness
Term
Animal CS of toxocariasis
Definition
Pot-bellied puppies
Spaghetti-like worms passed or vomited
Term
Infectious agent of Chagas disease
Definition
Trypanasomas cruzi
Term
Vector of Chagas disease
Definition
"Kissing bug"
Term
Acute CS of Chagas Disease
Definition
Flu-like with swelling at bite
Term
Chronic CS of Chagas Disease
Definition
Organ failure (usually the heart)
Term
How long can Chagas disease remain asymptomatic?
Definition
5-40 years
Term
What type of pathogen causes Listeriosis?
Definition
Listeria monocytogenes, a gram positive rod
Term
Transmission of Listeria
Definition
Ingestion of contaminated food and dairy products
Term
CS of Listeria in animals
Definition
Encephalitis ("circling disease")
Mastitis
Term
CS of Listeria in humans
Definition
Mild flu-like
GI/Fever
Abortions
Meningitis
Term
Which zoonotic disease is called "Wool sorter's disease"?
Definition
Anthrax
Term
What type of pathogen causes anthrax?
Definition
Bacillus anthracis (gram positive rod)
Term
CS of cutaneous anthrax
Definition
Skin pustules form blacked scabs
Can lead to septicemia and death
Term
CS of ingestion anthrax
Definition
Sudden death, bleeding from orifices
Term
Which species can have the chronic form of ingestion anthrax?
Definition
Dogs and horses
Term
CS of inhalation anthrax
Definition
Flu-like
Dyspnea, bloody V/D
Sepsis, death in 24-36 hours
Term
Most fatal form of anthrax infection
Definition
Inhalation
Term
Most common form of anthrax infection
Definition
Cutaneous
Term
When is ingestion anthrax most likely to be acquired?
Definition
After rain (spores released)
Term
How long do clinical signs of anthrax take to appear?
Definition
60 days
Term
Which type of pathogen causes Q Fever?
Definition
Coxiella burnetti, a gram negative proteobacteria
Term
Reservoir host of Q fever
Definition
Sheep, cattle, and goats
Term
Transmission methods of Q fever
Definition
Aerosolized from parturient tissue, urine, feces, or milk
Direct contact or ingestion of tissues
Term
CS of Q fever in animals
Definition
Can be subclinical or cause reproductive failure
Term
CS of Q fever in humans
Definition
Subclinical or flu-like, pneumonia symptoms
Term
Is there a vaccine for Q fever?
Definition
Yes, but not approved in US
Term
Other names for Brucellosis
Definition
Undulant fever
Malta fever
Bang's Disease
Term
Which type of pathogen causes brucellosis?
Definition
Brucella, a gram negative coccobaccilus
Term
Transmission methods of brucellosis
Definition
Direct contact
Ingestion
Inhalation
Term
CS of Brucellosis in animals
Definition
Abortion
Orchitis
Lymphadenitis
Term
CS of Brucellosis in humans
Definition
Undulating fever
Muscle and joint pain
Lymphadenitis
Term
How long does Q fever live in the environment?
Definition
6 months
Term
How long does Brucella live in the environment?
Definition
Several months
Term
Prevention of brucellosis
Definition
Vaccinate, good hygiene, pasteurization
Term
Why can brucellosis be misdiagnosed as, leading to underreporting of incidence?
Definition
Fever of unknown origin
Term
Cause of Rocky Mountain Spotted Fever
Definition
Rickettsia rickettsi (a gram negative coccobacilli)
Term
CS in dogs
Definition
Mild form: Flu-like
Severe form: Neuro signs, bleeding, heart damage
Term
CS in humans
Definition
Flu like
Spotted rash
Neuro signs
Pulmonary and circulatory damage
Term
How long must a tick remain attached to transmit RMSF?
Definition
4 hours
Term
Types of plague
Definition
Bubonic
Pneumonic
Term
Pathogenic agent of plague
Definition
Yersinia pestis (gram negative coccobaccili)
Term
Where is Yersinia pestis considered endemic?
Definition
Southern United States
Term
What is a chagoma?
Definition
Swelling around a bite from a kissing bug
Term
Which species is especially susceptible to plague?
Definition
Cats
Term
Which is the most common form of plague?
Definition
Bubonic (80%)
Term
What are buboes?
Definition
Swollen, painful lymph nodes
Term
CS of bubonic plague
Definition
Buboes, flu-like, toxemia, petechiae, bloody cough
Term
CS of septicemic plague
Definition
Epistaxis
Hematuria
DIC
Tissue necrosis
Term
Which form of plague is most fatal?
Definition
Septicemic
Term
CS of pneumonic plague
Definition
Flu-like with rapid progression to septicemia
Term
Which form of plague is a bioterrorism threat?
Definition
Pneumonic plague
Term
Which form of plague can be transmitted human to human?
Definition
Pneumonic plague
Term
How quickly must Tx for pneumonic plague be started to be effective?
Definition
24 hours
Term
What type of pathogen causes Cat Scratch disease?
Definition
Bartonella henselae (gram negative rod)
Term
Transmission methods of Bartonella
Definition
Cat bites or scratches
Term
CS of Bartonella in humans
Definition
Lymphadenitis
Abscess at lesion
Fever
Malaise
Splenomegaly
Term
Tx for Bartonella
Definition
Supportive care (not very responsive to Abx)
Term
Which modes of transmission of Tularemia are considered bioterrorism threats?
Definition
Ingestion (food and water), aerosol
Term
What type of pathogen causes Tularemia?
Definition
Francisella tularensis (a gram negative rod)
Term
Reservoir of tularemia
Definition
Cottontail rabbit and ticks
Term
Transmission methods of tularemia
Definition
Aerosol
Insect bite
Direct contact
Ingestion
Term
How long can tularemia survive in the environment or a dead animal?
Definition
Over 3 years
Term
6 types of tularemia
Definition
Ulceroglandular
Glandular
Oculoglandular
Oropharyngeal
Typhoidal
Pulmonary
Term
CS of ulceroglandular tularemia
Definition
Ulcers at infection sight
Swollen lymph nodes
Term
CS of glandular tularemia
Definition
Swollen lymph nodes
Term
CS of oculoglandular tularemia
Definition
Swollen lymph nodes
Conjunctivitis
Term
CS of oropharyngeal tularemia
Definition
Pharyngitis with pseudomembrane
Diarrhea with GI bleeding
Term
CS of typhoidal tularemia
Definition
Septicemia resulting from other forms or inhalation
Term
CS of pulmonary tularemia
Definition
Pneumonia
Complications from other forms
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