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Zoonoses / EIDs
JJC Vet Tech 255
191
Veterinary Medicine
Undergraduate 2
02/27/2015

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Term
Criteria for an EID:
Definition
1. new infection resulting from evolution or change of existing pathogen

2. known infection spreading to new geographic area or population OR

3. previously unrecognized pathogenic agent or Dz diagnosed for first time and which has a significant impact on animal or public health
Term
The 3 ways a zoonotic Dz can transmit to a person:
Definition
-directly
-from animal products
-vector
Term
T/F: Human-to-human transmission of a zoonosis is common.
Definition
FALSE, it's rare
Term
What is a vector-borne disease?
Definition
disease in which pathogenic microorganism is transmitted from an infected individual to another individual by a vector (arthropod or other agent)
Term
Transmission of a zoonosis depends upon the attributes and requirements of at least 3 living organisms, which are:
Definition
-the pathogen
-the vector
-the human host
Term
Factors influencing the emergence of infectious diseases:
Definition
-population growth
-deforestation
-expansion of human populations into previously uninhabited forested and suburban areas
-climate change
-speed/ease of travel
-pet trade / animal products
-dam building (changes ecosystem)
-war and social disruptions (refugee camps, etc)
-pathogen evolution
Term
What is the "yellow belt"?
Definition
Area around the equator in which Yellow Fever typically occurs (because of heat, mosquito vector, monkey reservoir), which will probably increase northward with climate change.
Term
How does climate change affect the transmission of WNV?
Definition
warm temps = longer season for mosquito vector
Term
What is the vector for Dengue Fever and Yellow Fever?
Definition
Aedes aegypti (mosquito)
Term
What is Aedes aegypti?
Definition
mosquito vector for Dengue and Yellow Fever
Term
In 2009 there was an outbreak of ____ in Florida.
Definition
Dengue Fever
Term
Deforestation and urbanization increase our contact with...
Definition
mosquitos
Term
Is there a vaccine for Yellow Fever? Dengue Fever?
Definition
Yellow - yes
Dengue - no
Term
What vector was found in California in the summer of 2013?
Definition
Aedes aegypti
Term
Book which talked about the link between animal health and human health?
Definition
Zoobiquity
Term
reservoir host
Definition
domesticated and/or wild animals that harbor a pathogen
Term
definitive host
Definition
host in which the pathogen reaches sexual maturity
Term
sentinel
Definition
any non-human organism that can react to an environmental contaminant before the contaminant impacts people
Term
seroprevalence
Definition
# of seropositive individuals in a population
Term
CDC Category A
Definition
most severe pathogens based on how easily they spread, kill, and cause panic
Term
CFR
Definition
Case Fatality Rate
-proportion of infected animals that die from a disease
Term
herd immunity
Definition
increased proportion of resistant individuals decreases the susceptible population
Term
Sentinel species are used as indicators of epidemics as well as ____.
Definition
bioterrorism
Term
T/F: Prion diseases are not zoonotic.
Definition
Maybe?! haven't yet made a direct link between vCJD and BSE
Term
BSE
Definition
Bovine Spongiform Encephalitis
Term
"Mad Cow Disease" is more formally called what?
Definition
Bovine Spongiform Encephalitis
Term
Prion disease in deer?
Definition
Chronic Wasting Disease
Term
vCJD
Definition
varient Creutzfeldt-Jakob Disease
Term
What type of virus is rabies?
Definition
Lyssavirus
Term
Of the people who survived rabies, most were ___.
Definition
pre-vaccinated
Term
How is rabies transmitted?
Definition
-saliva from raccoon, skunk, cat, dog, etc
-aerosolized bat excrement (rare)
Term
CS of rabies in animals? people?
Definition
Animals: behavior changes, paralysis, death
People: dysphagia, paralysis, death nearly 100% in 2-10 days
Term
Other names for "Orf:"
Definition
"contagious ecthyma"
"sore mouth"
Term
What type of virus is Orf?
Definition
poxvirus
Term
How is Orf transmitted?
Definition
-contact with lesions of sheep or goats
-crusts/scabs can remain infective in environment for years
Term
How to prevent Orf?
Definition
vaccinate sheep and goats
Term
CS of Orf in animals? humans?
Definition
Goats/Sheep: papules around mouth/lips that crust, scab off
People: chicken-pox type lesions on fingers, hands, face, and arms that can last 6 wks
Term
LCM
Definition
Lymphocytic Choriomeningitis
Term
What type of virus is LCM?
Definition
Arenavirus
Term
How is LCM transmitted?
Definition
-bites from mouse/hamster/other rodent
-fecal/urine contact
-organ transmission (donor had pet hamster)
Term
Reservoir host for LCM:
Definition
house mouse (Mus musculis) and possibly other wild mice
Term
CS of LCM in animals? people?
Definition
Rodents: asymptomatic
People: flu-like, can develop into meningitis (<1% fatality)
Term
What disease is under-reported due to lack of awareness, despite there having been historical outbreaks in research and pets?
Definition
LCM - Lymphocytic Choriomeningitis
Term
The CDC started an awareness program particularly for rodent breeders to inform them about what disease?
Definition
LCM
Term
What type of virus is WNV?
Definition
Flavivirus
Term
Reservoir host for WNV:
Definition
passerines (American robin and house sparrows = super spreaders)
Term
What is a "super spreader"?
Definition
host that disproportionately infects secondary contacts compared to other hosts infected with the same pathogen
Term
What are the "super spreaders" for WNV?
Definition
American robin, house sparrow; cardinal too
Term
What disease was discovered in the US by a Bronx Zoo vet in 1999?
Definition
WNV - West Nile Virus
Term
WNV
Definition
West Nile Virus
Term
Vector for WNV:
Definition
mosquito (Culex pipiens in IL)
Term
Culex pipiens
Definition
mosquito species that acts as vector for WNV in IL
Term
What disease has caused tens of thousands of animal deaths, including birds, horses, and many native and exotic species?
Definition
WNV
Term
CS of WNV in people?
Definition
-flu-like symptoms which resolve
-may have persistent fatigue
-neuroinvasive form: encephalitis, meningitis, paralysis, death
Term
What is SIR?
Definition
susceptible / immune / recovered or removed
Term
Birds have exhibited antibody decay to what disease?
Definition
WNV
Term
What type of virus is avian flu?
Definition
Influenzavirus A
Term
Reservoir for avian flu:
Definition
waterfowl and shorebirds
Term
What disease killed 20-40 million people globally including 675,000 Americans?
Definition
1918 Pandemic "Spanish Flu"
Term
Avian Flu is very similar to the Influenzavirus A that affects what species?
Definition
humans, pigs, horses, dogs
Term
antigenic drift
VS
antigenic shift
Definition
drift: point mutations

shift:
-subtype reassortment
-transfer of whole virus into new host
-re-emergence of previous virus
Term
1997 H5N1
Definition
-epizootic in poultry
-sporadic human cases
Term
Requirements for an epidemic:
Definition
1. new disease emerges in species with little to no immunity

2. pathogen must reproduce in that species

3. sustainable transmission in new species
Term
2003-4 H5N1
Definition
-epizootic in poultry in China
-470 human cases (rare person-to-person)
-60% case fatality rate in people
Term
Why are swine considered a "mixing vessel" for Influenzavirus A?
Definition
-they can get swine flu, bird flu, and people flu
-viruses may mix inside
Term
4 hemorrhagic viruses from the PP:
Definition
Hantavirus
Lassa
Marburg
Ebola
Term
What type of virus is Hantavirus?
Definition
Bunyavirus
Term
HPS
-what does it stand for?
-causative agent?
-where does it occur?
-symptoms?
Definition
-Hantavirus Pulmonary Syndrome
-Hantavirus
-US
-flu-like, rapid progression to respiratory failure, usually fatal (38% mortality)
Term
HFRS
-what does it stand for?
-causitive agent?
-where does it occur?
Definition
-Hemorrhagic Fever with Renal Syndrome
-Hantavirus
-Asia
-no symptoms listed on PP
Term
What disease is named after a river which runs between North and South Korea?
Definition
Hantavirus- HFRS
Haantan River
-during Korean war, 1000s died from it
Term
Disease that had an outbreak in 1993 in the "Four Corners" area of the US?
Definition
Hantavirus - HPS
Term
How many cases per year are there of HFRS?
Definition
150-200,000 cases/year
Term
Reservoir for Hantavirus:
Definition
deer mouse
Term
How is Hantavirus transmitted?
Definition
aerosol of dried mouse feces/urine/saliva
Term
What type of virus is Lassa?
Definition
-Arenavirus
Term
Reservior for Lassa:
Definition
NW and OW rats and mice
Term
How is Lassa transmitted?
Definition
-aerosolized virus
-direct contact
Term
What disease is the cause of 100,000-300,000 cases of febrile illness every year in West Africa?
Definition
Lassa
Term
What is the most frequently imported Arenavirus?
Definition
Lassa
Term
Hemorrhagic viruses have a characteristic shape to them called:
Definition
shepherd's hook
Term
BTT
Definition
Bioterrorist Threat
Term
What type of virus is Marburg?
Definition
Filovirus (Filoviridae)
Term
How is Marburg transmitted?
Definition
-direct contact
-possibly insect routes
Term
Reservoir for Marburg:
Definition
bats
Term
Symptoms of Marburg:
Definition
-acute = flu-like leading to hemorrhagic fever, V/D leading to DIC, thrombocytopenia, hemorrhage
Term
What diseases are highly fatal in humans and NHPs?
Definition
Marburg
Ebola
Term
What type of virus is Ebola?
Definition
Filovirus (Filoviridae)
Term
How is Ebola transmitted?
Definition
-direct contact
-possibly insect routes
Term
Reservoir for Ebola:
Definition
unknown
Term
Symptoms of Ebola:
Definition
-acute = flu-like leading to hemorrhagic fever
-V/D leading to DIC, thrombocytopenia, hemorrhage
Term
What human behaviors in Africa can make it difficult to stop the spread of Ebola?
Definition
-people want to care for the sick in their homes = contact with tissues, fluids
-want to wash body before burial
Term
8 BTT's from PP:
Definition
***all aerosolized***

-Lassa
-Marburg
-Ebola
-Anthrax
-Q-fever
-Brucellosis
-Pneumonic Plague
-Tularemia
Term
What disease was first discovered in 1967 in Germany, when researching working with African Green Monkeys became ill and died?
Definition
Marburg
Term
What disease has several subtypes including Reston and Sudan, named for the location in which they were identified?
Definition
Ebola
Term
acariasis
Definition
infestation with mites
Term
Mange:
-causitive agent?
-transmission
-what happens to people with it?
Definition
-Sarcoptes scabiei
-direct contact with animal
-self-limiting in people
Term
What is the non-zoonotic form of TB?
Definition
Mycobacterium tuberculosis
Term
3% of captive Asian elephants in the US are infected with _____ which they caught from humans.
Definition
M. tuberculosis
Term
Reservoir of Mycobacterium tuberculosis?
Definition
humans
Term
How is M. tuberculosis transmitted?
Definition
aerosol transmission from people
Term
What is a "reverse zoonosis"? Which diseases did we learn about that fit this category?
Definition
-disease spread to animals from humans -Mycobacterium tuberculosis; and M. bovis (also a zoonosis)
Term
Describe the disease process of TB:
Definition
-cell-mediated hypersensitivity contains replication within lung and lymph node granulomas
-reactivation esp. if immuno-compromised
Term
An estimated 1/3 of the world's population has what disease?
Definition
tuberculosis
Term
What are the zoonotic forms of TB?
Definition
Mycobacterium bovis (cattle)
M. avium-intracellulare (birds)
Term
MAC
Definition
Mycobacterium Avium-Intracellulare
Term
How is M. bovis transmitted?
Definition
-ingestion of unpasteurized milk
-aerosol
-reverse zoonosis to cattle
Term
T/F: Person-to-person transmission of M. bovis is uncommon.
Definition
TRUE
Term
How to treat M. bovis in cattle?
Definition
euthanize
Term
Reservoir for MAC:
Definition
broad host range including environmental
Term
What are the two species of MAC? How do they differ?
Definition
M. avium avium (serious in AIDS pts)

M. avium paratuberculosis
-Johne's disease in cattle (pronounced Yo-Knees)
-Chrohns disease in humans, possibly
Term
What pathogen is possibly the cause of Chrohn's disease in humans?
Definition
Mycobacterium avium paratuberculosis
Term
What is the most common zoonosis in the world?
Definition
Leptospirosis
Term
Leptospirosis:
-causitive agent?
-transmission
-CS in animals
-CS in people
Definition
-Leptospira (spirochete)
-direct: shed in urine of multiple spp, indirect: environmental
-animals: icterus, bloody diarrhea, renal failure
-people: mild (non-specific CS) and severe form (multi-organ failure and meningitis)
Term
What sort of environment does Leptospira require?
Definition
cannot live in dry enviros, requires high humidity
Term
Lyme Disease
-causitive agent
-vector
-symptoms in animals
Definition
-Borrelia burgdorferi (spirochete)
-deer ticks (Ixodes scapularis)
-usu. dog/horse/cattle: lameness, lymphadenitis, rash at tick site
Term
Common and scientific name of the Lyme Disease vector?
Definition
deer tick
Ixodes scapularis
Term
T/F: Dogs respond poorly to antibiotic Tx for Lyme disease.
Definition
FALSE- they respond well to Abx
Term
What disease has the most cases in the Northeast, North-Central, and West coast states?
Definition
Lyme Disease
Term
Early Lyme disease symptoms:
Definition
-erythema migrans appears at site of tick bite 7-10d in 90% symptomatic infections
-EM starts as red papule, expands over days to target-like lesion
-systemic: fever, myalgia, arthralgia, malaise, headache, stiff neck, lymphadenopathy
Term
Transmission of Borrelia requires ____ hours of tick attachment.
Definition
36-48 hrs
Term
Secondary Lyme disease symptoms:
Definition
3-5 wks after infection
-facial nerve palsy
-dizziness
-syncope (fainting)
-chest pain
-palpitations
-dyspnea
-uveitis
-meningitis
Term
Late Lyme disease symptoms:
Definition
weeks - months after infection
-asymmetric arthritis: large joints, esp. knee, only moderate tenderness
-may not respond to Abx in 10% adults and <5% children, then AI mechanisms of arthritis likely
-CNS: encephalitis, encephalopathy, polyneuropathy (periph. nerve damage)
Term
Causative agent/s of Visceral Larva Migrans?
Definition
Toxocara or Baylisascaris (roundworms)
Term
Toxocariasis
-transmission
-CS in animals
-CS in people
Definition
-fecal-oral
-Animals: pot-belly pups, spaghetti-like worms vomited or in poop
-People: cough, wheezing, abdominal pain, strabismus, blindness
Term
Echinococcus
-human infection is called what?
-definitive host?
-transmission?
-ova?
Definition
-hydatidosis
-carnivores
-fecal-oral
-indistinguishable from (????taenia or all cestodes? not sure)
Term
Hydatidosis is fatal in __% of cases.
Definition
75%
Term
Toxoplasmosis:
-causative agent?
-definitive/reservoir host?
-how does above species get it?
-how do they transmit it?
-what humans are particularly at risk? what happens to them if the get it?
Definition
-Toxoplasma gondii (protozoa)
-feline
-cat eats infected mouse/bird prey
-burrows into cat SI, oocysts shed 2-3wks and usually never again
-fetuses: birth defects incl. blindness
Term
Chagas is also known as:
Definition
American Trepanosomiasis
Term
Chagas disease is related to what African disease?
Definition
African Sleeping Sickness, also caused by trypanosome
Term
Causative agent of Chagas?
Definition
Trypanosomas cruzi
Term
Vector of Chagas?
Definition
"kissing bug"
-can also get from contaminated food
Term
Factors affecting who gets Chagas:
Definition
-poverty, occupational (vet med), hunters
Term
Chagas:
-aside from humans, what animal gets it?
-what are the CS signs in this animal and humans?
Definition
-dogs
-Acute: flu-like with chagoma
-Indeterminant: asymptomatic for 5-40 years
-Chronic: organ failure (usu. heart)
-dogs at risk for sudden death(???)
Term
Causative agent of Listeriosis? Where is it found?
Definition
-Listeria monocytogenes (Gm+ rod)
-in soil
Term
How is Listeria transmitted?
Definition
ingestion of contaminated food and dairy products = most common
Term
CS of Listeriosis in animals? people?
Definition
Animals: encephalitis ("circling disease") and mastitis
People: mild flu-like symptoms or GI/fever or abortions or meningitis (often fatal) in immunocompromised
Term
What pathogen can replicate in the refrigerator, and thus often is transmitted to people in contaminated food and dairy products?
Definition
Listeria monocytogenes
Term
Another term for cutaneous anthrax?
Definition
wool sorter's disease
Term
Cutaneous anthrax:
-causative agent?
-transmission?
-CS in people?
Definition
-Bacillus anthracis (Gm+ rod)
-spores on animal products or soil; or fly bite (95% cases worldwide)
-skin pustules form blackened scabs; untreated leads to septicemia and death (fatality 5-20%)
Term
What form of anthrax has the highest survival rate?
Definition
cutaneous anthrax (5-20%)
Term
In order to get inhalation anthrax, one must inhale how many spores?
Definition
2,500 - 55,000 spores for lethal inhalation dose
Term
When are ingestion anthrax outbreaks most common?
Definition
after rainfall
Term
CS of ingestion anthrax in animals?
Definition
-sudden death
-bleeding from orifices
Term
In Minnesota in 2000, a downer cow was approved for slaughter, and a family ate its well-cooked meat. They developed diarrhea, and more cows died before it was discovered that they had what disease?
Definition
ingestion anthrax
Term
2 phases of inhalation anthrax symptoms:
Definition
1st: flu-like
2nd: dyspnea, bloody V/D, sepsis, death within 24-36 hrs (fatality 75-95%)
Term
Fatality rate of inhalation anthrax?
Definition
75-95%
Term
Some animals with anthrax can survive, and the main indicator of their illness is:
Definition
chronic lymphadenopathy
Term
Never necropsy an animal if you suspect it has ____.
Definition
anthrax- will release spores
Term
How long does it take for inhalation anthrax to show clinical signs?
Definition
60d, then the second phase is more rapid
Term
What is the causative agent of Q-Fever?
Definition
Coxiella burnetti (Gm- proteobacteria)
Term
Q-Fever
-causative agent?
-reservoir?
-transmission?
-CS in animals?
-CS in people?
-How to prevent?
Definition
-Coxiella burnetti
-sheep, cattle, and goats = most common
-aerosol (urine, feces, milk, parturient tissues); direct contact with tissues; ingestion
-Animals: subclinical or repro failure
-People: 50% subclinical, up to 50% flu-like symptoms incl. pneumonia; chronic form ; relapse in 50%
-hygiene, pasteurization
Term
What disease is subclinical in 50% of people, and in up to 50% people causes flu-like symptoms including pneumonia?
Definition
Q-fever
Term
Is there a vaccine for Q-fever?
Definition
Yes, but not approved in US.
Term
How long can Coxiella burnetti survive in the environment?
Definition
6mo
Term
Other names for Brucellosis?
Definition
Undulant fever
Malta fever
Bang's Disease
Term
Brucellosis:
-causative agent?
-transmission?
-CS in animals?
-CS in people?
-how to eradicate?
Definition
-Brucella (Gm- coccobacillus)
-direct contact, ingestion, inhalation
-Animals: abortion storms!!!, orchitis, lymphadenitis
-People: undulating fever, muscle/joint pain, lymphadenitis
-US has vacc program; pasteurization and hygiene
Term
The US has a vaccination program for _____ which consists of a live, attenuated vaccine.
Definition
Brucellosis
Term
What pathogen likes high humidity and low temperature, and can survive in dust?
Definition
Brucella
Term
T/F: Brucellosis can be passed person-to-person.
Definition
TRUE- but rare; can be passed sexually, or by birth or nursing
Term
What sort of people are most likely to get Brucellosis? Why?
Definition
occupational disease so people who work closely with livestock
Term
What is the causative agent of RMSF?
Definition
Rickettsia rickettsi (Gm- coccobacillus)
Term
What pathogens are Gm- coccobacilli?
Definition
Brucella
Rickettsia rickettsi
Yersinia pestis
Term
How long must a tick be attached to transmit RMSF?
Definition
min. 4 hours
Term
RMSF:
-causitive agent?
-what does it stand for?
-vector?
-CS in Animals?
-CS in People?
Definition
-Rickettsia rickettsi (Gm- coccobacillus)
-Rocky Mountain Spotted Fever
-ticks (and possibly mites and fleas)
-Dogs: flu-like or severe: neurologic, bleeding, heart damage
-People: flu-like followed by rash and neuro/pulm/circulatory damage; high mortality
Term
How to treat Rickettsia?
Definition
Abx, but high mortality in people
Term
What is the causative agent of Black Death?
Definition
Yersinia pestis (Gm- coccobacillus)
Term
What disease killed over 1/3 the population of Europe, and 1/5 the population of England?
Definition
"Black Death" / plague / Yersinia pestis
Term
Reservoirs for plague?
Definition
-over 200 spp rodents (some get CS, some don't)
-rodents, lagomorphs = most common in US
Term
What animal is very susceptible to plague?
Definition
cats- fatal cases in pets, mountain lions, bobcats, etc
Term
___% of all plague cases are in the form of ___ plague, making it the most common form.
Definition
80% = bubonic
Term
CS of bubonic plague in people?
Definition
-buboes (swollen, painful lymph nodes)
-flu-like symptoms
-toxemia
-petechiae
-cough with bloody sputum
-dypsnea
Term
Fatality rate of bubonic plague?
Definition
50-60%
Term
How is plague transmitted?
Definition
vector = flea
Term
What species can be sero + for plague, but does not develop symptoms?
Definition
dogs
Term
Different forms of plague:
Definition
-bubonic
-septicemic/purpura
-pneumonic
Term
CS of septicemic/purpura plague in people? How fatal is it?
Definition
-epistaxis
-hematuria
-DIC
-tissue necrosis on extremities
-rapid progression, fatality 100%
Term
What is the least common form of plague?
Definition
pneumonic
Term
T/F: Pneumonic plague cannot be spread human-to-human.
Definition
FALSE - it's the only plague that can spread this way, through close contact / inhalation
Term
CS of pneumonic plague in people? How fatal is it?
Definition
-flu-like
-rapid progression to septicemia
-100% fatality
Term
Survival is very unlikely if treatment of pneumonic plague is not started within ___.
Definition
24 hours
Term
Causative agent of Cat Scratch Disease?
Definition
Bartonella henselae (Gm- rod)
Term
Cat Scratch Disease:
-reservoir?
-transmission?
-CS in animals?
-CS in people?
-Tx?
Definition
-felids
-cat bites or scratches
-Animals: cats are asymptomatic
-People: lymphadenitis, abscess at lesion, fever, malaise, splenomegaly
-supportive care (difficult to eliminate with Abx)
Term
What zoonotic disease is also considered an emerging infectious disease in the US, causing 24,000 cases / year that are very difficult to eliminate with antibiotics?
Definition
Bartonella henselae
Term
What pathogen is found in every state but Hawaii, can survive in the environment, dead animals, and even frozen meat for over 3 years?
Definition
Francisella tularensis (Gm- rod)
Term
Reservoir for Tularemia?
Definition
rabbits and ticks
Term
Who is mostly likely to get Tularemia?
Definition
hunters
Term
How is Tularemia transmitted?
Definition
aerosol, insect bite, direct contact, ingestion
Term
What are 6 the different types of Tularemia and how do they affect the body?
Definition
flu-like in all

1. ulceroglandular: ulcers, swollen/painful LNs

2. glandular: LNs

3. oculoglandular: LNs, conjunctivitis

4. oropharyngeal: pharyngitis with pseudomembrane, diarrhea, GI bleeding

5. typhoidal: septicemia following other forms or inhalation, 30-60% fatality if untreated

6. pulmonary: pneumonia, inhalation, complications from other forms, 30-60% fatality if untreated
Term
What disease can mimic bubonic plague because it causes swollen, painful LNs?
Definition
Glandular Tularemia
Term
How to treat Tularemia?
Definition
Abx
Term
What disease can mimic diphtheria by causing pharyngitis with a pseudomembrane over the tonsils? How is it contracted?
Definition
Oropharyngeal Tularemia from eating contaminated rabbit
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