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z devo eye normal development part II
David Harrington
24
Biology
Professional
12/14/2009

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Term
pigmented & non-pigmented
ciliary epithelium comes from (2)
Definition
outer layer optic cup --> pigmented
anterior extent of neural retina -->
nonpigmented
Term
ciliary muscle comes from
Definition
mesenchyme
Term
iris develops from
Definition
rim of optic cup
Term
iris epithelium derived from ~
Definition
both layers of optic cup
Term
stroma of iris is developed from
Definition
neural crest cells
Term
iris dilator and sphincter muscles are derived from
Definition
neuroectodermal cells of optic cup
Term
lens is derived from lens vesicle, which comes from _ _
Definition
surface ectoderm
Term
developing lens is supplied by _ _ which degenerates in fetal period
Definition
hyaloid artery
Term
after degeneration of hyaloid artery, the lens depends on _
Definition
diffusion
Term
developing lens is invested by (2)
Definition
tunica vasculosa lentis
pupillary membrane
Term
when hyaloid artery degenerates...
Definition
tunica vasculosa lentis
pupillary membrane
degenerate also
Term
choroid & sclera come from _ around _ _
Definition
mesenchyme
optic cup
Term
choroid and sclera formation -- caused by induction signals from ~ acting on ~
Definition
RPE
mesenchyme
Term
sclera is continuous with
Definition
dura that surrounds optic nerve
Term
choroid & sclera correspond with
Definition
pia and dura
Term
anterior chamber of the eye develops from _ of _ which is split
Definition
vacuolization of mesenchyme
Term
anterior chamber splits mesenchyme into ~ & ~
Definition
iridopupillary membrane

cornea: endothelium & substantia propria
Term
in front of the lens is the _ membrane
Definition
iridopupillary
Term
cornea is induced by _ _
Definition
lens vesicle
Term
cornea is formed from
Definition
surface ectoderm --> epithelium
mesenchyme --> middle layer
neural crest from optic cup
--> endothelium
Term
the key regulatory gene for eye devo
Definition
PAX6
Term
_ regulates _ and also down-regulates PAX6 to separate things into two optic primordial fields
Definition
Shh
PAX2
PAX6
Term
retina molecular regulation (2)
Definition
surface ectoderm FGFs --> neural retina
mesenchyme TGF-beta --> pigmented retina
Term
_ induces _ expression necessary for lens formation
Definition
PAX6
SOX2
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