Term
| Difference between Tween and Span |
|
Definition
Tween: oil in water
Span: water in oil
***both nonionic, sorbitan, fatty ester synthetic surfactants |
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|
Term
| Which ointment bases are water washable? |
|
Definition
| Water removable and Water soluble |
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|
Term
| Name the ointment bases in order |
|
Definition
1. Fatty Base
2. Absorption Anhydrous Base
3. Absorption Hydrous Base
4. Water-Removable Base
5. Water-Soluble Base |
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|
Term
| Which ointment bases are greasy? |
|
Definition
| Fatty base, Absorption Anhydrous Base, Absorption Hydrous Base |
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|
Term
| Which ointment bases are classified under H2) Absorption? |
|
Definition
Absorption Anhydrous
Absorption Hydrous
Water Removable
Water Soluble |
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|
Term
| Three Examples of Fatty Base/Hydrocarbon |
|
Definition
| White Petrolatum, White Cream, Vaseline |
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|
Term
| 4 Examples of Anhydrous Absorption |
|
Definition
Hydrophilic Petrolatum
Anhydrous Lanolin
Aquaphor
Aquabase |
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|
Term
| 3 Examples of Hydrous Absorption |
|
Definition
Hydrous Lanolin
Cold Cream
Eucerin |
|
|
Term
| 3 Examples of Water-Removable |
|
Definition
Hydrophilic Ointment
Vanishing Cream
Unibase |
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|
Term
| 1 Example of Water Soluble Ointment Base |
|
Definition
|
|
Term
| Oral suspensions- oil or water based? |
|
Definition
|
|
Term
| how do you minimize caking? |
|
Definition
|
|
Term
| sedimentation rates for flocculated and deflocculated systems? |
|
Definition
|
|
Term
| sedimentation volume for floc. and defloc. systems? |
|
Definition
|
|
Term
| void volume for floc and defloc systems |
|
Definition
|
|
Term
| what color are oil/water emultions? |
|
Definition
|
|
Term
| what color are emulsions that have a smaller droplet size? smallest? |
|
Definition
|
|
Term
| what do w/o emulsions look like? |
|
Definition
|
|
Term
| will water disperse if put in an o/w emulsion? |
|
Definition
|
|
Term
| is amaranth a water or oil soluble dye? |
|
Definition
|
|
Term
| describe a fluorescence test |
|
Definition
o/w: under fluorescent light, fluorescence appears spotty
w/o: under F light, entire field fluoresces |
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|
Term
| hydrophilic emulsifying agents have what kind of HLB? |
|
Definition
|
|
Term
| what kind of dosage forms are dermatologicals? |
|
Definition
|
|
Term
| a fluid preparation that offers no resistance to skin and settles under the force of gravity; newtonian flow |
|
Definition
|
|
Term
| semisolid preparation, does not flow under force of gravity, and as you rub it in the skin, the flow increases; pseudoplastic flow |
|
Definition
|
|
Term
| semisolid preparation, plastic flow, definite yield value (resistance) |
|
Definition
|
|
Term
| semisolid preparation, when applied resistance to flow increases with increased force of application; dilatent flow |
|
Definition
|
|
Term
| what are pseudoplastic systems? |
|
Definition
| "shear thinning systems"-viscosity decreases with increasing shear stress |
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|
Term
|
Definition
| shear stres is applied-it flows-then it takes some time to return to original state (like ketchup_ |
|
|
Term
| what are dilatent systems? |
|
Definition
| "shear-thickening systems"-viscosity increases with increasing shear stress |
|
|
Term
| what are the 3 classes of suppository bases? |
|
Definition
| fatty, water-dispersable, water-soluble |
|
|
Term
| 2 examples of suppository fatty bases? |
|
Definition
| cocoa butter (theobroma oil) and hydrogenated vegetable oil (cotton seed oil) |
|
|
Term
| advantages of using fatty suppository base? |
|
Definition
solid at room temp and melts at body temp
soft/smooth/nonirritating |
|
|
Term
| disadvantages of using fatty suppository base |
|
Definition
can't incorporate water-soluble drugs
polymorphic forms
greasy |
|
|
Term
| most stable polymorphism form of fatty base (supp)? |
|
Definition
|
|
Term
| 2 types of water-soluble supp bases |
|
Definition
PEG bases-high MW for solids
glycerinated gelatin bases-used in vag supps |
|
|
Term
| adv of water-soluble fatty base? |
|
Definition
| easily prepared and stored |
|
|
Term
| disadv of water-solutlbe supp bases |
|
Definition
|
|
Term
| what are water-dispersible supp bases? |
|
Definition
| can be o/w or w/o-depends on what kind of thickening agent you use (from notes) |
|
|
Term
| 3 types of inhalation aerosols? |
|
Definition
metered dose inhalers
dry powder inhalers
nebulizers |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| 3 examples of dry powder inhalers |
|
Definition
Rotahaler
Spinhaler
Diskhaler |
|
|
Term
|
Definition
| environmentally friendly (no propellant) |
|
|
Term
|
Definition
|
|
Term
| how r u supposed to inhale a dpi |
|
Definition
|
|
Term
| what is the rate limiting barrier for transdermal drug delivery systems |
|
Definition
|
|
Term
| which are more stable, suspensions or solutions? |
|
Definition
|
|
Term
| susp v solution...longer duration of action? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| whats the most commonly used emulsifying agent? |
|
Definition
|
|
Term
| layer that surfactants form? |
|
Definition
|
|
Term
| how do surfactants affect surface tension? |
|
Definition
decrease it
*think of physio: IRDS low surfactant, so they have high surface tens of alv. |
|
|
Term
| how do surfactants affect viscosity? |
|
Definition
|
|
Term
| what type of film do polymers form? |
|
Definition
|
|
Term
| how do polymers affect viscosity? |
|
Definition
|
|
Term
| how do polymers affect surface tension? |
|
Definition
|
|
Term
| what kind of emulsion do polymers promote? |
|
Definition
|
|
Term
| what kind of film does FDS/particulate colloid form? |
|
Definition
|
|
Term
| how do particulate colloids affect surface tension? |
|
Definition
|
|
Term
| how do particulate colloids affect viscosity? |
|
Definition
|
|
Term
| disadv of using QUATs as a surfactant? |
|
Definition
|
|
Term
| divalent salts of fatty acids....(Ca++ Mg++ etc) what kind of emulsion do they form? |
|
Definition
w/o
**other salts of fatty acids form o/w |
|
|
Term
| which ointment bases have oil present in them? |
|
Definition
|
|
Term
| which ointment bases have water present in them? |
|
Definition
| absorption hydrous, water removable, water soluble |
|
|
Term
| what are rectal suppositories used for? |
|
Definition
hemorrhoids and laxatives
(anti-emetics?) |
|
|
Term
| another term for vaginal suppositories? |
|
Definition
|
|
Term
| what are vag suppositories used for? |
|
Definition
| contraceptives, antimicrobials |
|
|
Term
| another term for urethral suppositories? |
|
Definition
|
|
Term
| what are urethral suppositories used for? |
|
Definition
|
|
Term
| how do u get the beta form of a suppository base? |
|
Definition
| melt at 40-50 and slowly cool |
|
|
Term
|
Definition
|
|
Term
| 2 examples of membrane moderated systems? |
|
Definition
|
|
Term
| 2 examples of matrix dispersion system |
|
Definition
|
|
Term
| which transdermal system has a rate-controlling membrane/? |
|
Definition
| membrane modulated system |
|
|
Term
| what is cold freon problem? |
|
Definition
| patient stops inhaling when aersol reaches back of throat |
|
|
Term
| optimal size pcle for asthma? |
|
Definition
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