Term
Yersinia pestis
reservoir
transmission
metabolism
virulence
toxins
clinical
diagnostics
misc |
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Definition
Wild rodents, rats, squirrels
flea bite
facultative anaerobe
temp sensitive: only expressed at 37C (temp inside macrophages)
Virulence is plasmid mediated
Fraction 1: capsular antigen, antiphagocytic
V and W proteins
nonmotile
Pesticin: kills other bact
Intracellular murine toxin
Bubonic plague: regional lymph nodes swell, buboes, high fever, conjunctivitis
Sepsis: bacteria survive in macrophages, spread to blood and organs
Pneumonic plague: happens during epidemics
Gram stain will reveal gram-neg rods with bipolar staining
Blood culture
Culture of bobo aspirate
Serology
Rapid diagnostic test: Ab against F1
Facultative intracellular parasite
Can accept plasmids from E. coli, shares many plasmids with enteric bact
SubQ hemorrhage -> blackish skin discoloration, "Black Death" |
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Term
Yersinia enterocolitica
reservoir
transmission
metabolism
virulence
toxins
clinical
diagnostics
misc |
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Definition
wild & domestic animals
unpasteurized milk
facultative anaerobe
VF are temp sensitive
Invasive
V&W proteins
Enterotoxin (like ST toxin of E coli): i/c cGMP levels
Enterocolitis: focal ulcerations in ilium and mesenteric LN
Arthritis
Rash
Cold enrichment of stool with saline
Facultative intracellular parasite
Bipolar staining |
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Term
Francisella tularensis
reservoir
transmission
metabolism
virulence
clinical
diagnostics
misc |
|
Definition
Rabbits, squirrels, ticks
Bite of tick, infected animals
Direct contact with infected tissue
Inhaled aerosolized organisms
Ingestion of containmated meat or water
Obligate aerobe
Requires cysteine
Capsule: antiphagocytic
Nonmotile
Tularemia:
Ulceroglandular
Pneumonia
Oculoglandular
Typhoidal: GI symptoms, fever
Culture dangerous, highly infective, requires addition of cysteine to blood agar media
Skin test
Measure rise in IgG Ab titer
facultative intracellular parasite |
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Term
Brucella
reservoir
transmission
metabolism
virulence
clinical
diagnostics
misc |
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Definition
B. melitensis: goats
B. abortus: cattle
B. suis: pigs
B. canis: dogs
contact with contaminated livestock
ingestion of infected milk
aerosolization in lab or due to bioterrorism
Obligate aerobe
Capsule
nonmotile
tropism for erythritol (in animal placentas)
Brucellosis
-undulating fever
-weakness
-loss of appetite
Induces abortions in animals
Culture of blood, BM, liver, LN
Serology
Skin test
Facultative intracellular parasites |
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Term
Pasteurella multocida
reservoir
transmission
metabolism
virulence
clinical
diagnostics
misc |
|
Definition
Part of NF of animals
bite from dog or cat
facultative anaerobe
capsule
nonmotile
wound infxns following dog or cat bite: may progress to infxn of nearby bones and joints
culture specimen on standard lab media
NOT a facultative intracellular organism! |
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