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reproductive, renal, respiratory, digestive systems have outs, circulatory, nervous, endocrine, muskulaskeletal, and immune don't |
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ligand, ligand + recepor, enzymes, 2nd messengers, enzymes, response! |
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agonist: mimics a ligand (insulin). antagonist: inhibits the action of a ligand (beta blockers) |
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types of ligand receptors |
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ligand-gated ion channel, g-protein receptors (releases protein subunits), receptor tyrosine kinases (rtk, dimerize), receptors linked to enzymes |
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cell-cell, autocrine (like t-cells, self stimulating), paracrine (chemical synapses, eg), endocrine (eg hormones) |
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protein horomone/steroid hormone diffs |
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protein: hydrophilic, binds to surface receptors steroids: hydrophobic, bind to intracellular receptors |
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how the synapse balance works |
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[K] larger in than out, [Na] larger out than in, opening [K] channels makes a gradient force, but the voltage force plays too! |
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dendrites, axon, soma, axon terminals, myelin sheaths, nodes of ranvier |
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draw the action potential mechanism voltage diagram |
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study of host protection from foreign macromolecules or invading response to them |
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four classes of pathogens? |
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bacteria, viruses, fungi, and parasites |
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innate (for extracellular) or adaptive (humoral or cell mediated, for vesicular or cytosolic antigens) |
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how an infected cell is destroyed |
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MHC-I shows protein part that is recognized by T-cytotoxic cell, that activates other T-c cells to kill 'em. OR phagocytosis and presentation by mhc-II and recognized by Thelper which activate other Thelper to get B cells producing antibodies or gets macrophages |
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a preparation of all or part of an infectious agent that primes the immune system to recognize it, without causing it |
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jenner made vaccine from cowpox lesions in dairymaids (probs - arm-to-arm method, and length of protection) |
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biotech of smallpox vaccine |
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naturally occuring, attenuated vaccine. 1940s showed large scale production of freeze dried vaccine |
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secondary much quicker and stronger than primary |
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prepares killed vaccine for polio (later someone develops oral) |
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natural, attenuated live vaccine (smallpox) killed virus (salk polio) lab attenuated virus (sabin polio) purificiation of subunit (hep. b) rcombinant dna to produce subunit (now hep b) dna vaccine (investigational) |
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