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WSU Pathophysiology Unit 7 Chapter 33
Alterations in Pulmonary Function
61
Pathology
Undergraduate 2
07/20/2011

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Term
Boyle's Law
Definition
Pressure and Volume are inversely related. V increases as P decreases.
Term
Dalton's Law
Definition
Total pressure is the sum of each gasses pressure (sum of partial pressures).
Term
Coughing
Definition
is a protective reflex that cleans airways with an explosive expiration to remove foreign particles.
Term
Dyspnea
Definition
SOB, caused by increased airway resistance, breathing is uncomfortable, flared nostrils and use of accessory muscles.
Term
When breathing the diaphragm
Definition
During inhalation the diaphragm contracts.
During exhalation the diaphragm is relaxed.
Term
Atmospheric pressure at sea level
Definition
760 mm Hg
Term
Alveolar pressure during inhalation
Definition
758 mm Hg
Term
Alveolar pressure during exhalation
Definition
762 mm Hg
Term
Tidal Volume
Definition
Normal breathing volume(500 mL).
Term
Inspiratory reserve
Definition
Inhalation in excess of normal inhalation volume (1900 to 3100 mL).
Term
Expiratory volume
Definition
Exhalation in excess of normal exhalation volume (700 to 1200 mL).
Term
Vital capacity
Definition
Inspiratory reserve, expiratory reserve, and tidal volume combined (3100 to 4800mL).
Term
Pleuritic Pain
Definition
Sharp, stabbing pain associated with breathing.
Term
Abnormal sputum
Definition
Sputum is mucus mixed with substances in lower respiratory tract. Changes (color, consistency, odor, and amount) provides information about a disease and disease progression.
Term
Hemoptysis
Definition
Coughing up blood or bloody secretions. Usually bright red and localized infection or inflammation causes damage to the bronchi or alveolar capillary membrane.
Term
Kussmaul Respiration
Definition
Decrease in blood pH causes hyperventilation. Results in increased respiratory rate, increase in tidal volume, and no expiratory pause.
Term
Labored breathing
Definition
Increased work of breathing, obstruction of large and small airways
Term
Pulmonary Fibrosis
Definition
particles that cannot be absorbed or excreted are trapped in the lungs. Stiffens the lungs and chest wall and decreases elasticity. Small tidal volume and tachypnea.
Term
Cheyne-Stokes Respirations
Definition
Bizarre breathing pattern because of alternating apnea and hyperpnea.
Term
Cyanosis
Definition
Bluish discoloration of mucous membranes and the skin caused by increased amounts of deoxygenated hemoglobin.
Term
What is blood oxygenation?
Definition
O2 sat 97-99% in arterial blood.
O2 sat 75% in venous blood.
Term
Cyanotic blood oxygenation
Definition
O2 sat <85% in arterial blood.
Term
Clubbing
Definition
Increased connective tissue and vasculature in fingers/toes because of chronic anoxia.
Term
Pulmonary ventilation (V)
Definition
V=Amount of air (in liters) entering lungs per minute.
Va=amount of air (in liters) entering alveoli per minute.
Term
Perfusion (Q)
Definition
amount of blood that flows through the lung capillaries each minute.
Term
Ventilation-perfusion coupling
Definition
The matching of pulmonary blood flow to oxygen.
Ventilation of alveoli=4.5L
Perfusion lung capillaries=5L
Term
Ventilation to Perfusion ratio
Definition
Ideally 1:1
Term
Internal respiration
Definition
Is a respiratory process that occurs in capillaries in which O2 is delivered to tissues and CO2 is carried back to lungs.
Term
Expiratory respiration
Definition
Is O2/CO2 exchange in the lung capillaries.
Term
Oxygen is carried by
Definition
Hemoglobin
Term
CO2 is carried by
Definition
Bicarb ion (HCO3-)
Term
Hypercapnia
Definition
Blood CO2 is too high.
Term
Hypoxemia
Definition
Blood O2 is too low.
Term
Pneumothorax
Definition
Air that has leaked into the pleural cavity which prevents thorax from developing a pressure difference.
Term
Atelectasis
Definition
Any abnormal structure in the alveoli of the lung. If alveoli are grapes then grapes are smashed.
Term
Pleural Effusion
Definition
Any abnormal or excess liquid in the alveoli that interferes with external respiration (gas exchange).
Term
Transudative effusion
Definition
Mechanism of pulmonary edema ie CHF.
Term
Exudative effusion
Definition
increase in lung capillary permeability that allows blood or plasma into alveoli.
Term
Bronchiectasis
Definition
Remodeling of the bronchi due to chronic inflammation. Bronchial smooth muscle replaced by connective tissue. Increases the width of the lumen but mucus narrows it.
Term
Bronchiolitis
Definition
Is chronic inflammation of the bronchioles. Connective tissue replaces smooth muscle. Narrowing of the bronchiole lumen.
Term
Acute Respiratory Distress Syndrome (ARDS)
Definition
Acute lung inflammation and diffuse alveolocapillary injury. Progressive deterioration of oxygenation results in respiratory difficulty or failure.
Term
ARDS is the most severe in...
Definition
Adults. Can also occur in children.
Term
ARDS is caused by
Definition
Some sort of injury to the alveolar-capillary membrane.
Term
What does Neutrophils lead to in ARDS
Definition
Pulmonary vasoconstriction, vascular occlusion and pulmonary hypertension.
Term
Alveolar Type 1 tissue
Definition
Surrounds the alveolar space preventing any fluid from interfering with gas exchange.
Term
Alveolar Type 2 cells
Definition
Produce surfactant. Surfactant reduces the surface tension of the liquid layer that moistens the alveolar walls.
Term
ARDS effects the alveoli how
Definition
The alveolar membrane breaks allowing flooding of the alveoli space preventing gas exchange.
Term
ARDS creates what membrane
Definition
Hyaline membrane. Protien and enzymes make it a jelly like substance. No gas exchange can occur.
Term
ARDS treatment
Definition
Mechanical ventilation.
Term
ARDS affects the heart by
Definition
ARDS increases pulmonary hypertension which leads to right sided hypertrophy.
Term
Obstructive Pulmonary Disease
Definition
Diseases that cause permanent narrowing of the small bronchi in which expiratory flow is slowed.
Term
COPD is
Definition
Asthma, Emphysema, and Bronchitis
Term
COPD causes
Definition
Airway obstruction of the bronchiole smooth muscle.
Term
Emphysema
Definition
Structural alterations. Alveoli loses elasticity.
Term
Bronchitis
Definition
Thick mucus with neutrophils.
Term
Asthma
Definition
Smooth muscle spasm and inflammation. Bronchoconstriction and excess mucus production.
Term
Asthma Treatment
Definition
Inhaled Bronchodilators which decrease smooth muscle spasm. Anti-inflammatory agents(glucocorticoids and leukotriene receptor blockers). These decrease mucus production and releases inflammatory mediators.
Term
Causes of Emphysema
Definition
Cigarette smoking. The smoke inhibits a lung enzyme called antitrypsinase. Also makes alveolar remodeling. Pt's with antitrypsinase deficiency spontaneously gets Emphysema.
Term
How does Emphysema affect breathing
Definition
Inspiration is intact while the ability to exhale is reduced. Lungs become over inflated. Muscles in chest wall have to work harder to expel the air.
Term
Bronchitis is caused by
Definition
Smoking, air pollutants, and infections.
Term
Bronchitis affects the lungs by
Definition
Inflammation and thickening of the respiratory membranes and accumulation of mucus and pus.
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