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womens: menstrual cycle
PA CLin Med
44
Medical
Graduate
04/25/2010

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Term
define oligomenorrhea:
Definition
35d<6mo
Term
define: hypomenorrhea:
Definition
reduction in the # of d or amnt of menstrual flow
Term
define polymenorrhea:
Definition
frequent bleeding; q21d or less
Term
define metrorrhagia:
Definition
irregular menstrual bleeding or bleeding btwn periods
Term
define menorrhagia:
Definition
prolonged or xs bleeding that occurs on regular intervals
Term
define menometrorrhagia:
Definition
frequent bleeding that is xs and irregular in amount and duration
Term
bleeding that occurs from a proliferative endometrium as a result of anovulation & the absence of any organic tissue:
Definition
Dysfunctional Uterine Bleeding
Term
uterine bleeding which occurs during chronic admin of exogenous estrogen at constant levels:
Definition
breakthrough bleeding
Term
occurs following acute cessation of constant exposure to estrogen:
Definition
estrogen withdrawal bleeding
Term
bleeding as a result of withdrawal of either endogenous or exogenous progesterone:
Definition
progesterone withdrawal bleeding
Term
period when ovaries begin failing to respond to LH/FSH
Definition
perimenopausal
Term
period when ovaries no longer respond to LH/FSH
Definition
menopause
Term
Estrogen afect on endometrium:
Definition
proliferates
Term
progesterone affect on endometrium:
Definition
maturation; stops proliferation
Term
what happens when progesterone reaches high levels?
Definition
Neg FB onto GnRH,
Term
describe the theca cell/granulosa cell relationship:
Definition
LH stimulates theca cells to produce androgens, granulosa cells convert androgen to estrogen in ovaries
Term
rapidly rising estrogen stimulates which phenomenon?
Definition
LH surge
Term
ovulation is indicated by the:
Definition
LH surge when follicle ruptures
Term
painful menstruation that prevents a woman from performing normal activities:
Definition
dysmenorrhea
Term
common age group for dysmenorrhea:
Definition
late teens early twenties
Term
prostaglandin affects on uterus:
Definition
intense smooth muscle contraction
Term
primary/secondary etiology of dysmenorrhea:
Definition
primary: xs prostaglandins
secondary: (1) endometriosis; (2)adenomyosis; (3)adhesions; (4)PID; (5)Leiomyomata (fibroids)
Term
adenomyosis:
Definition
endometrium invades the uterine muscle
Term
leiomyomata
Definition
uterine fibroids
Term
primary tx for dysmenorrhea:
Definition
1. contraceptives
2. NSAIDs (inhibit prostaglandin syn)
Term
syndrome w primary sx: emotional lability, abd bloating, fatigue
Definition
PMS
Term
which phase of the cycle does PMS occur?
Definition
luteal
Term
first choice for PMS tx:
Definition
SSRIs due to serotonin component
Term
3 tx for PMS
Definition
1. aerobic exercise/NSAIDs
2. SSRIs
3. oral contraceptives
Term
more severe form of PMS also caused by serotonin dysregulation
Definition
premenstrual dysphoric syndrome
Term
tx for premenstrual dysphoric disorder:
Definition
1. SSRIs
2. Yaz (only 4day progesterone withdrawal)
Term
non-cyclical endometrial bleeding unrelated to anatomical lesions of the uterus, pregnancy or systemic dz:
Definition
dysfunctional uterine bleeding
Term
cause of dysfunctional uterine bleeding:
Definition
1. extremes of reproductive life
2. PCOS
3. Obesity
4. Adrenal hyperplasia
Term
the very first menstrual cycle is known as
Definition
menarche
Term
etiology for dysfunctional uterine bleeding in menarche:
Definition
immature HPA axis feedback
Term
Anovulatory physiology:
Definition
continuous E production w/o E surge = no LH surge = no ovulation
Term
how does obesity lead to anovulation
Definition
fat cells produce estrogen leading to continuous elevation of E and no LH surge
Term
progesterone challenge:
Definition
anovulatory management: 400mg progesterone q night x7-10d, withdrawal initiates bleed. after 3-6mo tx then cycles may spontaneously establish. if no bleeding after withdrawal = uterine scaring
Term
absence of menses by age 13 wo secondary sexual characteristics or absence of menses at 15 w secondary sex characteristics
Definition
primary amenorrhea
Term
3 causes of primary amenorrhea:
Definition
1. vaginal agenesis (absence)
2. androgen insensitivity syndrome
3. turners syndrome (missing an X csome)
Term
most common cause of secondary amenorrhea:
Definition
pregnancy
Term
how would hyperprolactinemia affect menses?
Definition
amenorrhea via GnRH suppression.
Term
most common cause of hyperprolactinemia:
Definition
prolactinoma - pituitary tumor
Term
Asherman syndrome:
Definition
scaring of the uterine cavity: may b due to D&C... causes amenorrhea
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