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Wk 4 RS
The respiratory system
143
Medical
Undergraduate 1
08/12/2024

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Term
Organs of the respiratory system consist of:
Definition
Nose pharynx, larynx, trachea, bronchi, lungs/alveoli
Term
<> _________ between the blood and external environment occur only in the _________ of the lungs
Definition
Gas exchanges; Alveoli
Term
<> Upper respiratory tract includes passageways from the________
Definition
Nose to the larynx
Term
<> Lower respiratory tract includes passageways from the ______
Definition
trachea to alveoli
Term
How does the lower respiratory tract process air?
Definition
It purifies, humidifies, and warms the air
Term
The only externally visible part of the respiratory system (the nose) consists of 3 parts:
Definition
The nostrils (nares), Nasal cavity, and the nasal septum
Term
<> nostrils
Definition
Are the route through which air enters the nose
Term
<> Nasal Cavity
Definition
the interior of the nose
Term
<> Nasal septum
Definition
Divides the nasal cavity into the right and left side
Term
<> Olfactory receptors are located:
Definition
In the mucosa on the superior surface; the rest of the cavity is lined with respiratory mucosa
Term
The respiratory mucosa does what?
Definition
moisten air, traps incoming foreign particles, and destroy bacteria chemically with enzymes
Term
<> Conchae
Definition
Are projections from the lateral walls of the nose
Term
What is the purpose of conchae?
Definition
Increase surface area, air turbulence within the nasal cavity, and the trapping of inhaled particles
Term
The nose palate
Definition
Separates the nasal cavity from the oral cavity
Term
How are the nasal palates supported?
Definition
The hard palate is anterior and supported by bone, while the soft palate is posterior and unsupported
Term
How are the nasal palates supported?
Definition
The hard palate is anterior and supported by bone, while the soft palate is posterior and unsupported
Term
<> Paranasal sinuses are what?
Definition
Cavities within the frontal, sphenoid, ethmoid, and maxillary bones surrounding the nasal cavity
Term
paranasal sinuses do what?
Definition
Lighten the skull, act as a resonance chamber for speech, and produce mucous
Term
The Pharynx (throat) is what?
Definition
Muscular passageway from nasal cavity to larynx (continuous with the posterior nasal aperture)
Term
3 regions of the pharynx are:
Definition
the Nasopharynx, Oropharynx, and the Laryngopharynx
Term
<> Nasopharynx
Definition
superior region behind nasal cavity
Term
<> Oropharynx
Definition
middle region behind mouth
Term
<> Laryngopharynx
Definition
inferior region attached to larynx
Term
The Oropharynx and laryngopharynx serve as:
Definition
the common passageway for air and food
Term
<> the Epiglottis routes what?
Definition
Food into the posterior tube, the esophagus
Term
<> Pharyngotympanic tube
Definition
open into the nasopharynx (it also drains the middle ear)
Term
<> Tonsils are clusters of:
Definition
Lymphatic tissue that play a role in protecting the body from infection
Term
<> Pharyngeal tonsil (adenoid)
Definition
a single tonsil, which is located in the nasopharynx
Term
Palatine tonsils
Definition
are located in the oropharynx at the end of the soft palate
Term
<> Lingual tonsils
Definition
are found at the base of the tongue
Term
<> The larynx, commonly called _____, located inferior to the pharynx functions in _________
Definition
Voice box; routing air and food into proper channels and plays a role in speech
Term
The larynx is made of ________, and the _______ is the largest
Definition
8 rigid hyaline cartilages; thyroid cartilage (Adam's apple)
Term
<> Epiglottis
Definition
Spoon-shaped flap of elastic cartilage; protects the superior opening of the larynx; Routes food to the posteriorly situated esophagus and routes air toward the trachea; during swallowing this rises and forms a lid over the opening of the larynx
Term
<> Vocal folds (true vocal cords) do what?
Definition
Vibrate with expelled air; allow us to speak
Term
<> The glottis includes the what?
Definition
vocal cords and the opening between the vocal cords
Term
The trachea (windpipe) is how long? How is it reinforced?
Definition
It's a 4-inch-long tube that connects to the larynx; walls are secured with C-shaped rings of hyaline cartilage, which keep the trachea patent (open)
Term
How is the trachea lined?
Definition
Lined with ciliated mucosa
Term
Cilia beat continuously in the ______ direction of _______
Definition
Opposite direction; incoming air
Term
Ciliated mucosa expel mucus loaded with:
Definition
Dust and other debris away from lungs
Term
The main Bronchi is formed by
Definition
The division of the trachea
Term
At the hilum (medial depression) what happens?
Definition
Each bronchus enters the lungs
Term
The right bronchus is described as:
Definition
Wider, shorter, and straighter than the left
Term
Bronchi subdivide into:
Definition
Smaller and smaller branches
Term
The organs that occupy the entire thoracic cavity, excluding the central mediastinum, are:
Definition
The lungs
Term
The apex of the lung is located:
Definition
Near the clavicle (superior portion)
Term
The base of the lungs is
Definition
Resting on the diaphragm
Term
<> Each lung is divided into lobes by fissures classified as:
Definition
Left lung having 2 lobes, and Right lung having 3 lobes
Term
The Serosa that covers the outer surface of the lungs are know as:
Definition
Pulmonary (visceral) pleura and the Parietal pleura
Term
<> Pulmonary pleura
Definition
Covers the lung surface
Term
<> Parietal Pleura
Definition
Lines the walls of the thoracic cavity
Term
The pleural fluid, which fills the area between layers does what?
Definition
Allows the lungs to glide over the thorax; and decreases friction during breathing
Term
Pleural space is more commonly thought of as
Definition
Potential space
Term
The bronchial tree is a:
Definition
Network of branching passageways which have reinforcing cartilage in the walls except in the smallest ones
Term
The bronchial tree conduits to and from:
Definition
the respiratory zone
Term
<> Bronchioles are what?
Definition
The smallest conducting passageways of the bronchial tree
Term
Terminal bronchioles lead into the ______ and terminate in _______
Definition
Respiratory zone; alveoli
Term
<> Respiratory zone includes:
Definition
The respiratory bronchioles, alveolar ducts, alveolar sacs, and the alveoli (Air sacs)
Term
What happens at the site of the Alveoli?
Definition
It is the only site of gas exchange
Term
<> Conducting zone
Definition
These are structures that include all other passageways
Term
<> Alveoli shapes and structure
Definition
Simple squamous epithelial cells largely compose the walls; Alveolar pores connect neighboring air sacs; Pulmonary capillaries cover external surfaces of alveoli
Term
<> Respiratory membrane (air-blood barrier)
Definition
On one side of the membrane is air, and on the other side is blood flowing past; formed by alveolar and capillary walls
Term
Gas crosses the respiratory membrane by diffusion how?
Definition
Oxygen enters the blood; Carbon dioxide enters the alveoli
Term
Alveolar macrophages (dust cells)
Definition
these add protection by picking up bacteria, carbon particles, and other debris
Term
<> Surfactant (a lipid molecule)
Definition
Coats gas-exposed alveolar surfaces; secreted by cuboidal surfactant-secreting cells
Term
<> Functions of the respiratory system
Definition
Supply the body with oxygen; dispose of carbon dioxide
Term
<>Respiration includes four distinct events
Definition
Pulmonary ventilation; external respiration; Respiratory gas transport; Internal respiration
Term
<> Respiratory Gas Transport
Definition
Transport of oxygen and carbon dioxide via the bloodstream
Term
<> Internal Respiration
Definition
Gas exchange between blood and tissue cells in systemic capillaries
Term
<> Pulmonary ventilation
Definition
Moving air into and out of the lungs (commonly called breathing); Mechanical process that depends on volume changes in the thoracic cavity; Volume changes lead to pressure changes, which lead to the flow of gases to equalize pressure
Term
<> External respiration
Definition
Gas exchange between pulmonary blood and alveoli; Oxygen is loaded into the blood; carbon dioxide is unloaded from the blood
Term
<> Two phases of pulmonary ventilation:
Definition
Inspiration (Inhalation= flow of air into the lungs) and Expiration (exhalation= air leaving the lungs)
Term
Which muscles contract when inhaling or during inspiration?
Definition
The diaphragm and the external intercostals
Term
<> During Inhaling _______ increases and ________ decreases.
Definition
Intrapulmonary volume; gas pressure
Term
During inspiration, air flows into the lungs until intrapulmonary pressure _________
Definition
Equals atmospheric pressure
Term
The power of a person's expiration (exhalation) depends on
Definition
The lungs natural elasticity
Term
<> During exhalation Intrapulmonary volume _______ and gas pressure ________
Definition
Term
When exhaling, Gases passively flow ______________
Definition
Out to equalize pressure
Term
The muscles used to exhale
Definition
The internal intercostals which depress into the rib cage when they contract
Term
<> Intrapleural pressure
Definition
The pressure within the pleural space (which is always negative); It is the major factor in preventing lung collapse; If the pressure of this equaled atmospheric pressure the lungs would recoil and collapse
Term
Factors that affect respiratory capacity include:
Definition
Size, Sex, Age, Physical condition
Term
<> Tidal Volume (TV)
Definition
Normal quiet breathing; 500mL of air is moved in/out of the lungs with each breath
Term
<> Inspiratory reserve volume (IRV)
Definition
Amount of air that can be taken in forcibly over the tidal volume; Usually around 3100 mL
Term
<> Expiratory Reserve Volume (ERV)
Definition
Amount of air that can be forcibly exhaled after a tidal expiration; Approximately 1200 mL
Term
<> Residual volume
Definition
Air remaining in lung after expiration; Cannot be voluntarily exhaled; Allows gas exchange to go on continuously, even between breaths, and helps keep alveoli open (inflated); About 1200mL
Term
<> Vital capacity
Definition
The total amount of exchangeable air; Formula is TV+IRV+ERV; Generally, 4800mL in men and 3100mL in women
Term
<> Dead space Volume
Definition
Air that remains in conducting zone and never reaches alveoli; about 150 mL
Term
<> Functional Volume
Definition
Air that actually reaches the respiratory zone; Usually about 350 mL
Term
Spirometer
Definition
The instrument used to measure respiratory capacities
Term
Non-respiratory Air movements (NAM) can be caused by
Definition
Reflexes or voluntary actions
Term
NAM sneeze
Definition
Similar to a cough, except that expelled air is directed through nasal cavities instead of through oral cavity. The uvula, a dangling piece of tissue hanging from the soft palate, becomes depressed and closes oral cavity off from pharynx, routing air through the nasal cavities. This clears the lungs and upper respiratory passages of debris
Term
NAM Crying
Definition
Inspiration followed by release of air in a number of short expirations. Primarily an emotionally induced mechanism
Term
NAM Laughing
Definition
Similar to crying in terms of air movements produced. Is emotionally induced happy
Term
NAM Hiccups
Definition
Sudden inspirations resulting from spasm of diaphragm; initiated by irrigation of diaphragm or phrenic nerves, which serve diaphragm. The sound occurs when inspired air hits vocal folds of closed glottis
Term
NAM Yawn
Definition
Very deep inspiration, taken with jaws wide open; ventilates all alveoli (some alveoli may remain collapsed during normal quiet breathing)
Term
NAM cough
Definition
Taking a deep breath, closing glottis, and forcing air superiorly from the lungs against the glottis. Then, glottis opens suddenly and a blast of air rushes upward. This acts to clear the lower respiratory passageways
Term
<> A stethoscope measures
Definition
Sounds
Term
2 recognizable sounds that can be heard with a stethoscope are:
Definition
Bronchial Sounds and Vesicular breathing sounds
Term
Bronchial sounds
Definition
Are produced by air rushing through large passageways such as the trachea and bronchi
Term
Vesicular breathing sounds
Definition
These are soft sounds of air-filling alveoli
Term
Gas exchanges occur as a result of _______
Definition
Diffusion
Term
External respiration is an exchange of gases occurring _______
Definition
Between the alveoli and pulmonary blood (Pulmonary gas exchange)
Term
Internal respiration is an exchange of gases occurring between ________
Definition
The Blood and the tissue cells (Systemic capillary gas exchange)
Term
Movement of the gas is toward the area of ________
Definition
Lower concentration/pressure
Term
Oxygen is loaded into the blood and diffuses from the oxygen-rich air of the alveoli into _______
Definition
The oxygen-poor blood of pulmonary capillaries
Term
Carbon dioxide is unloaded out of the body and diffuse from the blood of the _________
Definition
Pulmonary capillaries to the alveoli
Term
Most oxygen travels attached to a hemoglobin and forms _________
Definition
Oxyhemoglobin (HbO2)
Term
A small amount of oxygen is dissolved and carried in
Definition
The Blood plasma
Term
Most carbon dioxide is transported in the plasma as_________
Definition
Bicarbonate ion (HCO3-)
Term
A small amount of CO2 is carried inside red blood cells on _______ but on a different _______ than oxygen
Definition
The hemoglobin; Binding sites
Term
For carbon dioxide to diffuse out of the blood and into the alveoli, it must ________
Definition
Be released from its bicarbonate form
Term
<> Transporting CO2: Step 1 Bicarbonate ions enters
Definition
The Red blood cells (RBC)
Term
Transporting CO2: Step 2 combine
Definition
Combine with hydrogen ions
Term
<> Transporting CO2: Step 3 Form
Definition
Form Carbonic Acid (H2CO3)
Term
Transporting CO2: Step 4 Split
Definition
Carbonic acid splits to form water + CO2
Term
Transporting CO2: Step 5 Diffusion
Definition
Carbon dioxide diffuses from blood into alveoli
Term
<> Loading
Definition
Carbon dioxide diffuses out of tissue cells to blood
Term
<> Unloading
Definition
Oxygen diffuses from blood into tissue
Term
Neural regulation
Definition
Setting the basic rhythm
Term
Activity of respiratory muscles is transmitted to and from ____
Definition
The brain by the phrenic nerves and intercostal nerve
Term
Neural centers that control rate and depth are located in _______
Definition
The medulla and pons
Term
Medulla does what for respiration?
Definition
Sets basic rhythm of breathing and contains a pacemaker (self-exciting inspiratory center) called the ventral respiratory group (VRG)
Term
What does the Pons do for respiration?
Definition
Smooths out the respiratory  rate
Term
<> Eupnea
Definition
Normal respiratory rate 12-15 per minute
Term
<> Hypernea
Definition
Increased respiratory rate, often due to extra oxygen needs
Term
<> Non-neural factors influencing respiratory rate and depth include:
Definition
Physical factors, Volition, Emotional
Term
<> Physical factors that control or influence Respiration
Definition
Increased body temperature, Exercise, Talking, and Coughing
Term
<> Volition Factors that control Respiration
Definition
Conscious control
Term
Emotional factors that influence respiration
Definition
Fear, anger, and excitement
Term
<> The most important stimulus for breathing is:
Definition
The body's need to rid itself of CO2
Term
Increased levels of CO2 in the blood increase the ____ and _________. Changes in carbon dioxide act directly on the ________
Definition
Rate; Depth of breathing; medulla oblongata
Term
<> Changes in oxygen concentration in the blood are detected by ________ in the aorta and the _________
Definition
Chemoreceptors; common carotid artery
Term
Oxygen is the stimulus for those systems who have become accustomed to high levels of _________ as a result of ______
Definition
Carbon dioxide; disease
Term
Hyperventilation
Definition
Rising levels of CO2 in the blood (Acidosis) results in faster, deeper breathing. During this, CO2 is exhaled more than produced, and it results in an elevated pH. Other possible complications include apnea and dizziness and can lead to alkalosis
Term
<> Hypoventilation
Definition
Results when blood becomes alkaline (alkalosis); Extremely slow or shallow breathing; allows CO2 to accumulate in the blood
Term
Chronic Obstructive Pulmonary Disease (COPD)
Definition
Exemplified by Chronic Bronchitis and Emphysema; Features include: Patients who have a history of smoking; Labored breathing becoming progressively worse; Coughing and frequent pulmonary infections are common; and most of these patients are hypoxic, retain carbon dioxide and have respiratory acidosis, and ultimately develop respiratory failure
Term
Chronic Bronchitis
Definition
Mucosa of the lower respiratory passages becomes severely inflamed; Excessive mucus production impairs ventilation and gas exchange; Patients become cyanotic and are sometimes called "Blue bloaters" as a result of chronic hypoxia and carbon dioxide retention
Term
Emphysema
Definition
Alveoli walls are destroyed; remaining alveoli enlarge; Chronic inflammation promotes lung fibrosis, and lungs lose elasticity; patients use a large amount of energy to exhale; some air remains in the lungs; sufferers are often called "Pink puffer" because oxygen exchange is efficient; Overinflation of the lungs leads to a permanently expanded barrel chest; Cyanosis appears late in the disease
Term
Lung Cancer
Definition
Leading cause of cancer death for men and women; Nearly 90% of cases result from smoking; Aggressive cancer that metastasizes rapidly; Most common are Adenocarcinoma, Squamous cell carcinoma, Small cell carcinoma
Term
lungs do not fully inflate until
Definition
2 weeks after birth
Term
<> Surfactant is formed _______ around __ to ___ weeks. Its job is to lower surface tension to ______________
Definition
late in pregnancy; 28; 30; prevent the alveoli from collapsing
Term
Respiratory rate in newborns
Definition
40-80 respirations per minute
Term
Respiratory Rate of infants
Definition
30 respiration per minute
Term
Respiratory rates for ages 5-11
Definition
25 respirations per minute
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