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Wk 27 Sex and Genetics
PLFSOM
13
Medical
Graduate
01/06/2012

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Cards

Term
What are the 2 phases of folliculogenesis?
Definition
1. Preantral or gonadotropin independent phase- Growth and differentiation of oocyte.

2. Antral or Gonadotropin Dependent Phase- Tremendous increase in follicle size
Term
When can atresia happen in folliculogenesis?
Definition
After class 1 or secondary follicle stage, highest incidence in small-medium (class 5,6,7) Graafian follicles
Term
Where does folliculogenesis occur?
Definition
Cortex of the ovary
Term
What does a primordial follicle have?
Definition
A primary oocyte arrested in the prophase of meiosis I.
Term
What is a primary follicle defined by?
Definition
The presence of cuboidal granulosa cells arranged in a single layer surrounding the oocyte.
Term
What is Sex Determination?
Definition
Translation of genetic sex into gonadal sex

Karyotype (46 XY or 46 XX) of the embryo (genetic sex) determine whether primordial gonad differentiates into a testis or an ovary respectively (gonadal sex).
Term
What is Sex Differentiation?
Definition
Translation of gonadal sex into acquisition of internal/external sex plumbing and organs
Term
What are the precursors to gametes?
Definition
Primordial Germ cells. Found in yolk sac near jxn of hindgut and allantois. Migrate 4-6 weeks after fertilization to developing genital ridges
Term
Draw out Sex Determination of Male
Definition
[image]
Term
Draw Sex Determination of Female
Definition
[image]
Term
Draw out Oogenesis
Definition
[image]
Term
What are the main points of Oogenesis?
Definition
1.Produces 1 egg and 2 polar bodies (all haploid).
2.Discontinuous process (oocytes arrest at MI and MII)
3.Oogenesis cycle for a particular oocyte can take months or years.
4.Only one egg is produced during a menstrual cycle.
Term
What are the main points of Spermatogenesis?
Definition
1.Produces 4 haploid sperms.
2.Continuous meiosis process starting at puberty.
3.Spermatogenesis cycle take 64 days
4.Continuous wave of spermatogenesis produce several millions of sperm per day.
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