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Wk 27 Drugs for Infertility
PLFSOM
7
Pharmacology
Graduate
01/06/2012

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Cards

Term
In male and female, what does LH stimulate?
Definition
progesterone synthesis in ovaries
testosterone synth in testes
Term
In male and female, what does FSH stimulate?
Definition
 stimulates ovaries to convert progesterone into estrogen
 stimulates spermatogenesis if enough testosterone
Term
Estrogen drives endometrial growth until when?
Definition
The luteal phase, day 21
Term
What is best for women with dysfunctional but intact H-P-gonadal axis with capacity for adequate estrogen production
Definition
They have most success with ovarian stimulation therapy: clomiphene and/or gonadotropins.
*Pt will have: avoluntary amenorrehea, dysfunctional uterine bleeding with anovulatory cycles
Term
How does Clomiphene work?
Definition
It blocks estrogen feedback inhibition on GnRH and Gonadotropins (LH/FSH)
Term
What is used in treating infertility due to hyperprolactinemia and why?
Definition
Bromocriptine. A dopamine agonist, it suppressed PRL and helps resume ovulation
Term
What is used for infertility due to hypothyroidism?
Definition
Thyroxine
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