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Link early to late life, linear Ex. Domestic violence that children witness |
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Focus on periods of psychological development |
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Concerned with patterns and pathways connecting early and later life Ex. Risk of developing cancer at different stages in life (and exposures at different stages) |
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Integrative approach; explains how “health trajectories” develop over an individual’s lifetime and how this knowledge can guide new approaches to research and policy Begins to tackle SDOH, context begins to matter; emphasis on early life Certain exposures affect different stages differently, specifically 0-6 (childhood, critical period) |
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1. Determinants of health operate in nested genetic, biological, behavioural, social, and economic contexts that change as we develop 2. Health Development: an adaptive process, made up of multiple transactions between contexts and biobehavioural regulatory systems that define human functioning 3. Health trajectories shaped by cumulative risk, protective factors, and other influences programmed into this biobehavioural regulatory system during critical and sensitive periods 4. Health development influenced by timing and sequence of biological, physiological, cultural, and historical events and experiences. |
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critical/sensitive periods |
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Critical Period is when a developmental path is determined. A sensitive period is a period of development when a favourable or unfavourable exposure has a stronger effect than it would have at other times. |
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depict the interactions between the economic, social, physical, behavioural, cultural, and other environments that mediate, or modify individual functioning. Typically involve risk and protective factors that define the path of health development. Micro – translate information from social relationships, environmental exposures, and historical events into biological information that alters the functioning of biological processes. |
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risk and protective factors |
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risk – lower health development trajectories. Proective – help raise trajectories |
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Macrocontexts/environments that provide the context of health development |
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- Genetic Endowment of Species, Physical Environment (availability of resources, food, water pathogen exposure), Social environment (income, economic resources, prosperity/disparities), family environment, psychological environment, culture and policy environment, health care system |
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Microcontext which impacts the design and process of health development |
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- Design feature and Strategies: selection of resources, optimization of function; integration and coordination of bio-behavioural processes; growth, maturation and compensation - Health development processes: physiological pathways and systems; behavioural pathways and systems; psychological pathways and systems. |
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3 basic mechanisms that influence LCHD |
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Cumulative: additive effect of multiple risks and protective factors Programming: time-specific influence of exposures during critical or sensitive periods in our development Pathways: chains of exposure (at all levels) that create a constrained conduit of gene-environment transactions |
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