Term
| Dopamine Theory of Schizophrenia |
|
Definition
o Changes in amount of DA metabolites in plasma, urine & CSF |
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|
Term
| Symptoms of Schizophrenia |
|
Definition
1. positive sx
2. negative sx
3. aggressive sx
4. depression/anxiety
5. cognitive sx |
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Term
| Positive Sx of Schizophrenia |
|
Definition
1. delusions
2. hallucinations
3. disorganized/distorted speech
4. catatonia
5. agitation |
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Term
| Negative Sx of Schizophrenia |
|
Definition
1. blunted affect
2. emotional/social withdrawal
3. cognitive impairment
4. anhedonia
5. avolition |
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|
Term
| Antipsychotics: Phenothiazines |
|
Definition
[typicals]
Chlorpromazine (Thorazine)
Thiroridazine (Mellaril) |
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|
Term
| Antipsychotics: Thioxanthenes |
|
Definition
[typicals]
Thiothixene (Navene) |
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|
Term
| Antipsychotics: Butyrophenones |
|
Definition
[typicals]
Haloperidol (Haldol) |
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Term
|
Definition
Clozaril;
atypical antipsychotic;
D2 & 5HT2a antagonist |
|
|
Term
|
Definition
Zyprexa;
atypical antipsychotic;
5HT2a > DA antagonist |
|
|
Term
|
Definition
Geodon;
atypical antipsychotic;
D2, 5-HT2A, 5-HT1D antagonist |
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|
Term
|
Definition
Abilify;
atypical antipsychotic;
D2 and 5-HT1a partial agonist; 5-
HT2a antagonist |
|
|
Term
|
Definition
Seroquel;
atypical antipsychotic;
5-HT2a, D2 antagonist |
|
|
Term
|
Definition
Risperdal;
atypical antipsychotic;
5-HT2a = D2 antagonist |
|
|
Term
|
Definition
restless, random movement;
motor side effect of antipsychotics |
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|
Term
|
Definition
weird posturing w/ limbs;
motor side effect of antipsychotics |
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|
Term
| Important Serotonin (5HT) Receptors |
|
Definition
| 5HT1A, 5HT2A, 5HT1B/D, 5HT2C |
|
|
Term
|
Definition
stimulates the release of DA;
important 5HT receptor |
|
|
Term
|
Definition
inhibits release of DA;
important 5HT receptor |
|
|
Term
|
Definition
autoreceptor that inhibits release of 5HT;
important 5HT receptor |
|
|
Term
|
Definition
inhibits release of DA (particularly in the mesolimbic system);
agonists of 5HT2C decrease food intake;
antagonism of 5HT2C can lead to weight gain;
important 5HT receptor |
|
|
Term
| Side Effects of Antipsychotics (6) |
|
Definition
(1) EPS,
(2) hyperprolactinemia,
(3) drowsiness,
(4) orthostatic hypotension,
(5) anhedonia,
(6) metabolic syndrome |
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|
Term
|
Definition
side effect of antipsychotics;
extra pyramidal sx due to decreased DA function in striatum (of BG);
stiatum rcvs DA innervation from nigrostriatial pathway --> death of substantia nigra (source of NSP) results in Parkinson's |
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|
Term
|
Definition
side effect of antipsychotics;
too much prolactin release from anterior pituitary;
Anterior pituitary is innervated by tuberoinfundibular pathway (DA);
DA inhibits prolactin release;
DA antagonism relieves DA inhibition |
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|
Term
|
Definition
side effect of antipsychotics;
H1 histamine receptor antagonism;
central alpha1 adrenergic receptor antagonism |
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Term
|
Definition
side effect of antipsychotics;
DA antagonism in NA |
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|
Term
|
Definition
side effect of antipsychotics;
unknown mechanism |
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|
Term
|
Definition
side effect of antipsychotics;
light headedness after standing up (BP drops);
peripheral alpha1 adrenergic receptor antagonism |
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