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Week 4
Chapter 20 Antineoplastic & Immunosuppressive Drugs
27
Pharmacology
Undergraduate 3
11/24/2014

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Term
Antineoplastic & chemotherapeutic drugs.
Definition
This class of drugs stop cancerous activity of malignant cels. Act s. characteristics unique to malignant cells.
Term

Cell-cycle-nonspecific. (CCNS)

 

Definition
Antineoplastic agents that act during any phase of the cell cycle. They kill during the dividing or resting phase.
Term
Cell cycle specific. (CCS)
Definition
Antineoplastic agents that act during specific phase of the cell cycle. Effective vs. rapidly growing cancer cells.
Term
Growth fraction
Definition
The percentage of the cancer cells that are actively dividing.
Term
Cells are divding rapidly.
Definition
When there is a high growth fraction cells are:
Term
Cells are dividing slowly.
Definition
When there is a low growth fraction cells are:
Term
high growth fraction.
Definition
In general antineoplastic agens are ore effective against cancer cells with a?
Term
Doubling time
Definition
Time required for the # f cancer cells to divide.
Term

Antineoplastic drugs

(Cell cycle-nonspecific)

Definition
Cyclophosphamide (Cytoxan), Cisplatin, Carboplatin, & Doxorubicin (Adriamycin) are examples of what drug class?
Term

Antineoplastic

(Cell cycle specific)

Definition
5-Fluorouracil, Vincristine, & Vinblastine are examples of what class of drugs?
Term

Body surface area.

(BSA is dtermined from BW in kg using charts)

Definition
What are calculaions of antineoplastic drugs based on?
Term
72 hrs and disposed of properly.
Definition
When handling antineoplastic waste, is is considered contaminated for how long?
Term
Vertical airflow hood with PPE.
Definition
Reconstitution of antineoplastic agents is done in a?
Term

same area should not be used again with in a 2 hour period.

 

Definition

When administering antineoplastic agents, an IV catheter placement muct be a good stick &?

 

Term
No
Definition

Is it a good idea for pregnant women to handle antineoplastic agents?

 

Term
No
Definition
Should immuno-compromised people handle antineoplastics?
Term
Eat or drink
Definition
You should not do this while handling antineoplastic drugs?
Term
Biologic response modifiers (BRM's)
Definition
agents used in conjuntion with antineoplastic agents to enhance the body's immune system.
Term
Interferons
Definition
Group of naturally-occuring proteins that have antitumor & antiviral effects.
Term
Interleukins
Definition
Immune enhancer group of chemicals that play various roles in the immune system.
Term
Acemannan
Definition
A chemical used in treatment of fibrosarcoma & MCT's (mass cell tumors) in dogs and cats They stimulate macrophage activity.
Term
Monoclonal antibodies.
Definition
Identical immunoglobulin molecules that have cytotoxic effects on tumor cells.
Term
Immunosuppresive drugs
Definition
Drugs that work mainly by interfering with one of te stages of the cell cycle or by affecting cell messangers. Used primarily to treat immune-mediated disorders in which the immune system is overactive.
Term
Immunosuppresive drugs
Definition
Atopica, Imuran, & Cytoxan are examples of what types of drugs?
Term
Enzymes
Definition
L-asparaginase (Elspar) works by making asparagine unavailable to malignant cells and is an example of an?
Term
Enzyme inhibitors
Definition
These control the growth of tumor cells. Example: Toceranib (Palladia)
Term
Immunosuppressive drugs
Definition
Adverse reaction to these types of drugs include: bone marrow supression, GI effects, Alopecia, Infertiity, Cardiotoxicity.
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