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Week 4
Ch 14 ntimicrobials
79
Pharmacology
Undergraduate 3
11/23/2014

Additional Pharmacology Flashcards

 


 

Cards

Term
Antimicrobials
Definition
Chemical substances that have the capability to kill or inhibit the growth of microorganisms.
Term

Biocidal

 

Definition
Capacity to kill miororganisms.
Term
Biostatic
Definition
Inhibit the growth of microorganisms.
Term
Antibiotics
Definition
Antimicrobials for bacteria are called?
Term
Spectrum of action
Definition
Antibiotics are described by their?
Term
Gram (+) bacteria
Definition
Resists decolorization by Grm stain process. Stain purple.
Term
Gram (-) bacteria.
Definition
Decolorized by the Gram stain process and stai pink-red.
Term
Narrow Spectrum  antibiotics.
Definition
Drugs specified for either Gram (+) or Gram (-) bacteria are considered?
Term

Broad Spectrum Antibiotics.

 

Definition
Drugs used for both Gram (+) and Gram (-) bacteria are considered?
Term
Render the bacteria helpless without causing harm to the patient.
Definition
Goal of antibiotic therapy:
Term
Kirby Bauer Test
Definition
Test used to measure a bacteria's sensitivity to an antibiotic.
Term
R=Resistant
Definition
Kirby Bauer sensitivuty test outcome where the antibiotic doe not work against these bacteria.
Term
I=Intermediate.
Definition
Kirby Bauer Sensitivity test outcome where the antibiotic may work against these bacteria.
Term
S=Sensitive
Definition
Kirby Bauer Sensitivity test outcome where antibitoics do work against these bacteria.
Term
Minimum Inhibitory Concentration (MIC)
Definition
The lowest concentration of an antibiotic that will at least inhibit the growth of bacteria.
Term
Bactericidal
Definition

This activity or type of antibiotic will inhibit cell wall synthesis.

 

Term
Bactericidal or bacteriostatic
Definition
The activity or type of this antibiotic damage cell membrane.
Term
Bactericidal or bacteriostatic
Definition
The activity or type of this antibiotic inhibit protein sythesis of bacteria.
Term
Bacteriostatic
Definition
This activity or type of antibiotic interfere with metabolism of bacteria.
Term
Bactericidal
Definition
The activity or type of this antibiotic cause impairment of nucelic acids.
Term
Antibiotic resistance
Definition
This occurs when bacteria change in some way that reduces or eliminates the effectiveness of the medication.
Term

The medication is not used properly

When used with a viral infection..

Not administered at a proper dose.

Not administered for the proper length of tme.

Definition
Antibiotic resistance can occur if:
Term
Antibiotic residues
Definition
The presence of a chemical or its metabolites in animal tissue or food products.
Term
Cell Wall Agents
Definition
This type of antibiotic affect the cell walls of bacteria & do not attack the host since animal cells do not have cell walls.
Term
Cell Wall Agents
Definition

Penicillins, Cephalosporins, Bacitracin and Vancomycin are what class of antibiotics?

 

Term
Penicillins
Definition
This type of antibiotic is derived from natural and sythetic derivations of molds. It is active against Gram (+) and Gram (-) bacteria. Can only be given parenterally. Narrow spectrum.
Term
Penicillian G (Pen G)
Definition
Most common type of penicillian antibiotic administered.
Term
Broad Spectrum Penicillians.
Definition
Amoxicillin, Ampicillin, & Methicillin are categorized as this type of penicillians.
Term
Beta-lactamase resistant penicillians.
Definition
Oxacillin & Floxacillin are narrow spectrum antibiotic categorized as these penicillians.
Term
Potientiated Penicillians
Definition
This category of penicillians are combined with another drug to enhance the effect of both.
Term
Definition
Clavamox and Augmentin are examples of this category of penicillian antibiotics.
Term
Cephalosporins
Definition
Semi-synthetic broad spectrum antibiotics that interfere with cell wall sythesis. Classified in 1st-4th generations. Animals allergic to penicillians will likely be allergic to these.
Term
Cephalosporins
Definition

Cefe-drops, Kerflex, & Cefazolin are examples of this category of antibiotics in the cell wall agents class.

 

Term
Bacitracin
Definition
This category of antibiotics in the cell wall agents class work against Gram (+) bacteria, are toxic to kidneys, used as a topical for skin, mucus membraes and eyes. Also used as a food additive.
Term
Vancomycin
Definition

This is used against many Gram (+) bacteria on infections that are resistant to toxic antibiotics such as penicillians and cephalosporins.

 

Term
Cell Membrane Agents
Definition
This class of antibiotics attack the cell membrane of bacteria.
Term
Polymyxin
Definition
This example of a cell membrane agent antibiotic is effective against Gram (-) bacteria only and is usualy combined with neomycin & bacitracin to create a wide spectrum topical medication.
Term
Protein Synthesis Agents
Definition

Agents that interfere with the protein synthesis in the bacterial cell are in this class of antibiotics.

 

Term
Protein Synthesis Agents
Definition
Aminoglycosides, Tetracyclines, Chloramphenicol, Florfenicol, Macrolides, & Lincosamides are examples of this class of antibiotics.
Term
AminoGlycosides
Definition
This category of Protein Sythesis agent antibiotics are derived from species of streptomyces microbes. Used extensivel to treat Gram (-) bacterial infections. Highly toxic to kidneys, Examples include: Gentamicin, Neomycin, & Amikacin.
Term
AminoGlycosides
Definition
This category of Protein Sythesis agent antibiotics should not be given to cats who are prone to renal failure.
Term
Tetracyclines
Definition
This category of Protein-Synthesis Agent antibiotics are broad spectrum and have anti-rickettsial properties. Theya re bacteriostatic, slow bone development and cause discoloration of teeth. Example: Doxycycline used for kenne cough, tick fever, & lyme Dz.
Term
Chloramphenicol
Definition
This category of Proten Sythesis Agent antibiotics is broad spectrm. suppresses blood cell formation in bone marrow and can cause aplastic anemia in humans. Banned from use in food-producing animals. Must wear gloves when handling.
Term
Florfenciol
Definition
This category of Protein-Synthesis agents is synthetic, broad spectrum, and used to treat bovine respiratory disease.
Term
Macrolides
Definition

This category of Protein Sythesis agent antibiotics can cause stomah upset. Examples include: Erythromycin, Tylosin, & Tilmicosin.

 

Term
Lincosamides
Definition
This category of Protein Synthesis agent antibiotics are produced from a different strain of streptomyces than macrolides or aminoglycosides. they work against Gram (+) bacteria. Examples include: Lincomycin, & Clindamycin,
Term
Nucleic Acid Agents
Definition
This class of antibiotics interfere with bacterial nucleic acid. This includes Quinolones, & Fluoroquinolones.
Term
Nucleic Acid Agents
Definition

Erofloxacin (Baytrl), Ciprofloxacin (Cipro), Orbifloxacin (Orbax), & Marbofloxacin( Zeniquin) are examples of what class of antibiotics?

 

Term
Miscellaneous Antibiotics
Definition
This class of antibiotivs include Nitofurans, are broad spectrum, less potent than other antibiotivs, & are prohibited from use in food animals because they may induce carciogenic residues in animal tissue.
Term
Miscellaneous Antibiotics
Definition
Nitofurzone,  Nitrofurantoin, Nitrpimidazols, and Rifampin are exampes of which class of antibiotics?
Term
Nitroimidazoles
Definition
Metronidazole is in this category of Miscellaneous antibiotics.
Term
Antifungals
Definition
Type of medicine used to fight against fungus.
Term
Superficial
Definition
This type of fungal infection is diagnosed through test edia or microscopic identification.
Term
Systemic
Definition

This type of fungal infection is identified through serology.

 

Term
Polyene Antifungals
Definition
This category of antifungals bind to fungal cell membrane. Examples include: Nystatin & Amphotericin B
Term
Imadazole Antifungals
Definition
This category of antifungals cause leakage of fungal cell membrane. Identifided by "-azole" in generic name. Examples include: Ketoconazole, Miconazole, Itraconazole, & Fluconazole.
Term
Antimetabolic Antifungals
Definition
This category of antifungals is given orally & topically in combination with other antifungals to treat Cryptococcus infections. Example: Flucytosine.
Term
Superficial Antifungals
Definition
This category of antifungals include Griseofulvin which teats dermatophyte infections (ringworm).
Term
Antivirals
Definition
These are limited to use in vet med and work by prventing viral penetration of the host cell. Inhibits virus production of RN or DNA. Examples include: Acylovir, Tamiflu, & Interferon.
Term
Disinfecctant
Definition
This kills or inhibits growth of microorganisms on inanimate objects.
Term
Antiseptic
Definition
This kills or inhibits growth of microorganims on livng tissue.
Term
Germicide
Definition

This is a chemical that kills microorganims.

 

Term

Virucidal

 

Definition
A chemical that kills viruses.
Term
Fungacidal
Definition
A chemical that kills fungi.
Term
Sporicidal
Definition
A chemical that kills spores which are especially resistant to chemicals.
Term

Phenols

 

Definition
This is the first antiseptic that is effective against Gam (+) bacteria, some Gram (-) bacteria, fungi, & some enveloped viruses. Not effectie against parvo. Example: Lysol.
Term
Quaternary Ammonium Compounds
Definition

This type of disinfectant is effective against Gram (+) & Gram (-) bacteria. Not effective on spores, fungi, and non-enveloped viruses. Not usually irritating to skin. Example: Roccal-D

 

Term
Aldehydes
Definition
Gluteraldehydes used to disinfect instruments in cold steriization and on fiberoptics. Sporicidal.
Term
Formaldehydes
Definition
Used to disinfect instruments in gas or solution. Can also be used as tissue floatation agent.
Term
Ethylene Oxide
Definition
This is a gas used for chemical sterilization.
Term
Alcohol
Definition
Used on Gram (+) and Gram (-) bacteria. Used on enveloped viruses, not for antiseptic purposes, and can cause pain and has denaturing effect on proteins. Usally 70% solution used.
Term
Halogens
Definition
This disinfectant kills bacteria, fungi, viruses, & spores. Found in bleach & usually used in 1:10 dilution. Example: Chlorine (Chlorox)
Term
Iodine
Definition
This halogen disinfectant is usually mixed with water or alcohol to form brown solution. Commonly used as a topical antiseptic. Example: Betadine, Povidine.
Term
Biguanides
Definition
This type of disinfectant is effective vs. bacteria, some fungi, & enveloped viruses. Commonly used in surgical scrub. xample: Chlorhexidine (Nolvasan).
Term
Hydrogen Peroxide
Definition
This disinfectant kills anaerobic bacteria in deep wounds, but should limit use because it can damage animal tissue.
Term
Soaps & Detergents
Definition
These disinfectants have limited bactericidal activity and their main function is to mechanicaly remove microbes.
Term
Tylosin (Tylan)
Definition
This macrolid can be used off label in dogs and cats to stop diarrhea.
Term
Sulfadimethoxine (Albon)
Definition
This antimetabolite drug is the most common drug used against coccidia.
Term
Lufeneron (Program)
Definition
Most popular superficial antifungal.
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