Term
| Bifunctional alkylating agents |
|
Definition
- Nitrogen mustards
- Nitrosoureas
- Platinum analogues
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Term
| Monofunctional alkylating agents |
|
Definition
|
|
Term
| These drugs work through Aziridium ions |
|
Definition
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Term
| These drugs work through decomposition of vinyl diazotic acid |
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Definition
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Term
| These drugs work by binding adjacent guanine residues in the grooves of DNA |
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Definition
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|
Term
| What is the role of Mesna? |
|
Definition
- Counteracts Acrolein from cyclophosphamide
- Protects bladder & Kidney
|
|
|
Term
| Resistance to alkylating agents |
|
Definition
- Decreased permeability
- Increased repair
- trapping agents
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|
|
Term
| Can alkylating agents cause cancer? |
|
Definition
|
|
Term
| Dose limiting effect of nitrogen mustards |
|
Definition
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Term
| Advantages of Lomustine over Carmustine |
|
Definition
- More stable
- Less likely to form isocyanates
- Increased alkylating activity
- Oral
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Term
| Are platinum compounds cell cycle specific? |
|
Definition
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|
Term
|
Definition
- Renal impairment
- Ototoxicity
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|
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Term
|
Definition
- Hypersensitivity (instead of renal)
- No nephro because dicarboxylate
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|
Term
|
Definition
- Cold sensitivity (instead of renal and hypersensitivity)
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|
Term
| How is Cyclophosphamide transported into cells? |
|
Definition
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