Term
|
Definition
- RNA damage
- Myelosuppression
|
|
|
Term
|
Definition
- DNA damage
- Hand/foot syndrome
|
|
|
Term
| What is the role of leukovorin for 5-FU? |
|
Definition
- Increases formation of TS/5-FU complex
- Increased activity of 5-FU
|
|
|
Term
| What is the role of leukovorin for folic acid analogs? |
|
Definition
- reduces folate to cell
- antidote to FA antagonists
|
|
|
Term
|
Definition
- Enzyme of 5-FU metabolism
|
|
|
Term
| Advantages of Capecitabine |
|
Definition
|
|
Term
| What is needed to convert Capecitabine to 5-FU? |
|
Definition
|
|
Term
| Advantage of Pralatrexate over methotrexate |
|
Definition
- higher affinity for RFC = better drug uptake
|
|
|
Term
| Advantage of Pemetrexed over methotrexate |
|
Definition
- Targets multiple enzymes
- Granted by methylene
|
|
|
Term
| Enzyme that transforms 6-MP into 6-TGN |
|
Definition
|
|
Term
|
Definition
|
|
Term
Which is active against purine biosynthesis?
MeTIMP
MeTGMP |
|
Definition
|
|
Term
Purine Genetics
CI in patients with ___ deficiency |
|
Definition
|
|
Term
What is dCK?
Overcome by who |
|
Definition
- Nucleoside phsophorylation
- Cloferabine
|
|
|
Term
| Does Clofarbine enter cells pasively or through transporters? |
|
Definition
|
|
Term
| Does Nelarabine enter cells pasively or through transporters? |
|
Definition
|
|
Term
| GTP is the active form of___ |
|
Definition
|
|
Term
|
Definition
| Transporters that confer drug resistance |
|
|
