P: Population/disease ( i.e. age, gender, ethnicity, with a certain disorder)

I: Intervention or Variable of Interest (exposure to a disease, risk behavior, prognostic factor)

C: Comparison: (could be a placebo or "business as usual" as in no disease, absence of risk factor, Prognostic factor B )

O: Outcome: (risk of disease, accuracy of a diagnosis, rate of occurrence of adverse outcome)

T: Time: The time it takes to demonstrate an outcome (e.g. the time it takes for the intervention to achieve an outcome or how long participants are observed).