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The study of disordered function. involves the mechanism of the development of disease (Pathogenesis) AND the response of the organism to the disease |
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the mechanism of the development of disease |
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Science that deals with activities or function of the body and its parts. These activities can also be compensatory and adaptive responses of a healthy body. |
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Study of the cause of any disease or the theory of its origin (Smoking for instance) |
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Self-originating or without any known cause (We don’t know what caused it!) |
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Symptom. What if unconscious? |
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Changes in body function felt by patient. Subjective. They are asymptomatic, but will show signs of unconsciousness through visual examination or tests. |
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Changes in body function observed by others. |
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Characteristic group of signs and symptoms . such as Diabetes (triad of polydipsia, polyuria and polyphagia ) |
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Outcome of the disease - impairments that follow or are actually caused by the disease process. Think, inflammatory processes. Scar formation. |
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A new or separate process that may arise secondarily to changes produced by the original disease or outcomes resulting from the treatment of the disease. Is NOT an essential part of the disease. (such as acetoacidosis, a complication due to diabetes in some patients.) |
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An adverse condition in a patient that has been induced by a treatment. |
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Gradual and subtle development (slow and sneaky process) |
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Increase in the severity of a disease or any of its signs or symptoms. Alcohol exacerbates the effects of some drugs. |
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Conditions that exist at birth. However remember these conditions don't always manifest themselves at birth. Huntington's Disease would be an example. |
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Factors that predispose or contribute to the development of a particular disease. |
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Maintenance of constant conditions in the internal environment |
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what is the most useful measure of the health on an organism |
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The ability of that organism to ADAPT to its external environment to MAINTAIN HOMEOSTASIS. |
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How do organisms maintain their metabolic (physiologic) function. |
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what are the requirements of regulated feedback systems? |
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Receptor/Sensor, Integrator/Comparator, Effector System |
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When homeostasis cannot be maintained, perhaps due to a failure in the regulatory feedback system. what occurs? |
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Disease is sometimes decribed as a form of life that is beyond the normal. Normal is established statistically from test results obtained from a ____ |
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With the normal range of values being +/- 2 SD's of the normal distribution. what is the normal serum sodium, potassium, hemoglobin? |
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[Na]: 135 - 146 mM, [K]: 3.3 - 5 mM, [Hemoglobin]: 12 - 17 g/dL. Note hemoglobin values differ between the sexes with men typically having more hemoglobin. |
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Understanding a patient's circadian rhythms can help you provide a rationale for ______ of disease and how that patient may respond to ___ |
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day/night incidence patterns, diagnostic testing and medications |
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