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Definition
The study of the precise control of biological functions through exogenous application of chemicals
-- Seeks to define the functional relationship btwn concentration of ligand & biological response
-- That functional relationship is referred to as the dose-response function and is the central unifying principle of the science of pharmacology |
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Definition
| a molecule that forms a complex (binds to) a biomolecule |
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Definition
a molecule generated by a living organism
-- Proteins, carbohydrates, lipids, nucleic acids |
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Definition
a ligand that alters biological function (stimulates a biological response) by binding to a biomolecule
-- External chemical signal (chemical stimulus) |
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Definition
a biomolecule that initiates a biological function when it forms a complex with a ligand
-- Receiver of the external chemical signal |
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Definition
| 1 mole = 6.023x10^23 particles (molecules) |
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| 1 mole dissolved into 1L of solvent (amount/volume) |
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Definition
concentration;
Modern pharmacologic theory has developed from the concept of biologically active chemicals in solution interacting w/ receptors;
Pharmacologic constants are derived in units of molarity;
1 mole = 6.023x1023 particles (molecules);
molarity is concentration expressed as moles/liters (amount/volume) |
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Definition
| expressed in units of molarity |
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Term
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Definition
1) obtain the molecular weight of the solute (substance being dissolved -- drug)
2) determine the amt of solute (by weight in grams)
3) divide the amt of solute by its molecular weight (this gives you the # of moles)
4) divide the # of moles by the volume of the solvent (water, saline, etc.)
5) result = moles/liter; 1 mole/liter = 1 molar solution |
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| Molar Concentrations to Remember |
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Definition
1 molar (1M) = 1 mole/L
1 millimolar (1mM) = 1/1000 mole/L
1 micromolar (1uM) =1/1,000,000 mole/L
1 nonomolar (1nM) = 1/1,000,000,000 mole/L
1 picomolar (1pM) = 1/1,000,000,000,000 mole/L
1 fentomolar (1fM) = 1/1,000,000,000,000,000 mole/L |
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