Term
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Definition
| sensory neurons that respond to noxious stimuli |
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Term
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Definition
caused by disease or damage to somatosensory neurons;
peripheral or central;
ex: spinal cord injury, MS, diabetes, virus, cancer |
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Term
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Definition
Widespread pain;
More common in women;
Allodynia – painful responses to normal pressure; Additional dysfunctions:
- Fatigue
- Joint stiffness
- Sleep disturbances
Co-morbid w/ depression & anxiety;
Causes unknown;
Pharmacotherapy = FDA approval for pregabalin & duloxetine |
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Term
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Definition
Morphine;
Levorphanol;
Methadone;
Hydromorphone;
Hydrocordone;
Oxycodone;
Tramadol;
Fentanyl |
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Term
| Sites of Action for Tramadol |
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Definition
u-opioid receptor antagonist;
NET;
5HT2C;
TRPV1 |
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Term
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Definition
| -NSAIDS act by inhibiting COX enzymes (1 & 2) |
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Term
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Definition
- non-selective COX inhibitors (aspirin, ibuprofen, naproxen)
- selective COX-2 (Celebrex, Vioxx, Bextra) |
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Term
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Definition
NSAID;
Celebrex;
probably no advantage over ibuprofen or acetaminophen |
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Term
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Definition
NSAID;
Vioxx;
withdrawn in 2004 (increased risk of heart attack/stroke) |
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Term
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Definition
NSAID;
Bextra;
withdrawn in 2005 (increased risk of heart attack/stroke) |
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Term
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Definition
acetylsalicylic acid;
irreversible inhibitor of COX |
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Term
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Definition
potentially fatal disease;
rash, vomiting, liver damage, encephalopathy;
mostly children - rare in adults;
cause unknown, but associated w/ aspirin use |
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Term
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Definition
not a NSAID;
not associated w/ Reye's Syndrome |
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Term
| Reversible COX Inhibitors |
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Definition
ibuprofen (Advil, Motrin);
Naproxen (Aleve, Naprosyn) |
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Term
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Definition
NSAID;
reversible COX inhibitor |
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Term
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Definition
NSAID;
reversible COX inhibitor |
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Term
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Definition
derived from codeine;
sold in combo w/ acetaminophen or NSAID |
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Term
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Definition
Oxycontin = long-acting formula;
Perodan = oxycodone/aspirin;
Percoset = oxycodone/acetaminophen |
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Term
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Definition
- Tramadol;
- Fentanyl;
- Pregabalin & Gabapentin |
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