Term
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Definition
Most common childhood leukemia
Thrombocytopenia, anemia
Tdt +
Bone pain
Philly gene, <2 yo, or >100,000 peripheral blasts = bad
Good prognosis if 2-10 yo.
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Term
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Definition
NOTCH 1 often mutated
Manifests in thymus
Adolescent males |
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Term
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Definition
CLL has leukocytosis.
Most common leukemia in older pts.
Decreased gammaglobulins (low B cells)
Proliferation centers (mitotically active cells)
CD 5 +
Prolymphocytes in periphery
Smudge cells
Non-specific symptoms. Can become more aggressive by transforming.
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Term
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Definition
PALS replace with B cells (in spleen)
BCL 2
Relatively common (due to low apoptosis) |
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Term
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Definition
CD 5 +
No proliferation centers
Cyclin D1 +
Fatigue, GI complaints
Paratrabecular aggregates in marrow. |
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Term
| Diffuse large B-cell lymphoma |
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Definition
Most common adult lymphoma
BCL 6
EBV driven in AIDS pts
HHV8 (kaposi) always seen if effusion/pericarditis
No marrow, liver, or spleen involvement
Waldeyer ring often involved.
Curable but aggressive. |
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Term
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Definition
Starry sky / prominent nucleoli / EBV
B-cell IgM involvement
MYC mutation always.
maxillary, mandibular pain.
curable. |
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Term
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Definition
IgG hypersecretion
Skeletal lytic lesions
Bence-Jones proteins in urine (free light chains)
older patients. hypercalcemia from bone lesions. |
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Term
| Lymphoplasmacytic lymphoma |
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Definition
Usually IgM overload which causes Waldenstrom
Waldenstrom = viscous blood, neuro, reynaud.
balanced light/heavy chain production
no bence-jones or bone lesions. |
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Term
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Definition
Anatomical progression
Reed-sternberg cells (big, owl-eye)
Nodular sclerosis is most common type (lacunar and collagen bonds)
Mixed cell type is in old males.
Lymphocyte predominance = popcorn cells in axilla/cervical nodes.
Clinical stage is most important in prognosis. |
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Term
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Definition
Mucosal sites (maltoma)
Usually a secondary process (esp w/ sjogrens)
Treat underlying syndrome |
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Term
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Definition
older males
"Dry tap" for marrow aspirate
Splenomegaly**, pancytopenia.
Atypical mycoplasma infections
Good prognosis. |
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Term
| Peripheral T cell lymphoma |
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Definition
| lymphadenopathy, eosinophils, pruritis, fever |
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Term
| Anaplastic T cell lymphoma |
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Definition
ALK gene
good prognosis
clusters at venules |
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Term
| Adult T-cell leukemia/lymphoma |
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Definition
HTLV-1
affects CD4 cells
progressive demyelination |
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Term
| Mycosis fungoides/Sezary syndrome |
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Definition
CD4.
exfoliating erythemoderma |
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Term
| Large granular lymphocytic leukemia |
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Definition
anemia and neutropenia
larges cells with lots of blue cytoplasm
felty syndrome |
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Term
| Extranodal NK/T cell lymphoma |
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Definition
EBV
affects small vessels
nasopharyngeal mass |
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Term
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Definition
Auer rods
often see DIC
t(15;17)
myeloperoxidase +
tx: ATRA (tretinoin) |
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Term
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Definition
Most common subtype
t(18;21)
Auer rods
myeloperoxidase + |
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Term
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Definition
t(9;22) (philly)
low LAP
older males
tx: tyrosine kinase inhibitor (imatinib) |
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Term
| Myelodysplastic syndromes |
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Definition
Refractory anemia
Fe in mitochondria (ringed sideroblasts)
cytopenia |
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Term
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Definition
1. Calvaria defects
2. Diabetes insipidus
3. Exophthalmos |
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Term
| Letterer Siwe - Langerhans histiocytosis |
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Definition
multi-system involvement
seborrheic eruption
clonal proliferation |
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