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essential cofactor in enzymes for energy KREBS CYCLE |
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Cardinal symptoms of deficiency: polyneuropathy, edema, cardiac failure |
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Wernicke syndrome w/ progressive dementia ataxia and opthaloplegia (paralysis of extraoccular muscles) |
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seen in conjunction with deficiencies of other water soluble vitamins
LESIONS OF FACIAL SKIN/CORNEAL EPITHELIUM |
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Cheilosis (fissures of skin on open angles of mouth) Seborrheic dermatitis - tongue is smooth and purplish (magenta) |
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Corneal Interstital keratitis |
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Pellagra is deficiency of |
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Three Ds of deficiency: dermatitis, diarrhea, dementia |
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Areas exposed to light (face and hands) and those subjected to pressure (knees and elbows) have rough scaly dermatitis
AKA GLOVE DERMATITIS |
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Psychosis myelin degenerates in spinal cord. Resembles sub acute combined degeneration of vitamin B12 |
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Functions as coenzyme in metabolic pathways: AAs, lipids, heme, neurotransmitters |
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almost always seen in cases of pernicious anemia and results from lack of secretion of intinsic factor in stomach which prevents absorption in ileum |
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Fish tapeworm, Diphyllobothriumlatum leads to vitamin B12 deficiency |
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Neurological manifestations are seen in htis but not folic acid deficiency |
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Supplments of this during early pregnancy show decrease in incidence of fetal neural tube defects (NTDs) |
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hypogonodal dwarfism in boys |
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Mycrocytic hypochromic anemia (same as lead intoxication) |
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Wilson Disease deposits in brain, liver, cornea |
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Excess of this results in Mycocytic Hypochromic anemia (same as lead poisoning, copper def) |
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Deficiency causes poor growth, skeletal abnormalities, reproductrive impairment, ataxia, convulsions |
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Exposure to industrial levels of this substance causes symptoms like parkinsonism |
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