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chemical substances that have the capacity to kill or hinhibit the growth of microorganisms |
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Definition
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inhibit the frowth of microorganisms |
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Definition
chemicals that work on bateria |
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Definition
the range of bacteria on which the agent is effective |
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Definition
resist decolorization by gram stain process (stains purple) |
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Definition
decolorized by gram stain process (stain pink-red) |
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narrow spectrum antibiotic |
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Definition
drug specified for either gram (+) or gram (-) |
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Term
broad spectrum antibiotics |
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Definition
drugs used for both Gram (+) and Gram (-) |
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Definition
drugs that inhibit the growth or replication of the organism |
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Definition
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goal of antibiotic therapy |
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Definition
render the bacteria helpless without causing harm to the patient |
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Definition
antibiotic disc test to determine sensitivity |
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Definition
the antibiotic does NOT work against these bacteria |
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Definition
antibiotic may work against these bacteria |
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Definition
antibiotic DOES work against these bacteria |
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Definition
minimum inhibitory concentration |
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Minimum Inhibitory Concentration |
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Definition
the lowest concentration of an antibiotic that will at least inhibit the growth of bacteria |
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Term
Inhibition of cell wall synthesis |
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Definition
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Definition
bactericidal or bacteriostatic |
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inhibition of protein synthesis |
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Definition
bactericidal or bacteriostatic |
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interference with metabolism |
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Definition
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Term
impairment of nucleic acids |
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Definition
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Definition
occurs when bacteria change in some way that reduces or eliminates the effectiveness of the medication |
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Term
antibiotic resistance occurs when: |
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Definition
medication is not used properly used with a viral infection improper dose or improper length of time |
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Term
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Definition
presence of a chemical or its metabolites in animal tissues or food products |
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Term
even at low levels residues can cause allergic resistance that's transferred to people who consume food |
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Definition
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Definition
cell wall agents cell membrane agents protein synthesis agents antimetabolites nucleic acid agents miscellaneous |
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Definition
affect the cell walls of bacteria & do not attack the host since animal cells do not have cell walls |
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cell wall agents (examples) |
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Definition
penicillins cephalosporins bacitracin vancomycin |
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Definition
natural & synthetic derivatives of molds broad spectrum drug beta-lactum structure that interfers with cell wall synthesis in newly formed bacteria |
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Definition
penicillin G (most common, narrow spectrum) Penicillin Procaine G Benzathine Penicillin G (provides longer blood levels) |
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Penicillin Broad spectrum examples |
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Definition
amoxicillin ampicillin methicillin |
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Penicillin Beta-lactamase resistant penicillins (narrow spectrum) examples |
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Definition
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Definition
(combined w/ another drug to enhance the effects of both) amoxicillin/clavulanic acid clavamox & augmentin |
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Cephalosporins (1st - 4th generations) |
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Definition
semi-synthetic, broad spectrum antibiotics that interfere with cell wall synthesis cephadroxil (cefa-drops) cephalexin (keflex) cefazolin |
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Definition
disrupts the cell wall but by a different mechansim toxic to kidneys used as topical for skin, mucous membranes, eyes also used a food additive works against Gram + bacteria |
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Definition
used against many gram + bacteria on infections that are resistant to toxic antibiotics such as penicillins or cephalosporins |
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Definition
attack the cell membrane of the bacteria Polymyxin B - usually combined w/ neomycin & bacitracin to create a wide spectrum topical medication |
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Definition
agents that interfere with the protein synthesis (DNA transmittance) in the bacterial cell |
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Definition
aminoglycosides tetracyclines chloramphenicol florgenical macrolides lincosamides |
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Definition
derived from species of streptomyces microbes used to treat gram - bacterial infections poorly absorbed from GI tract highly toxic to kidneys identified by -mycin, -micin ending in generic name |
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Aminoglycosides (examples) |
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Definition
gentamicin neomycin amikacin |
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Definition
broad spectrum bacteriostatic slows bone development & causes discoloration of teeth not approved for dairy cattle -cycline ending in generic name |
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Definition
tetracycline doxycycline - used in treatment of kennel cough, tick fever, lyme disease |
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Definition
Broad spectrum suppresses blood cell formation in bone marrow banned from use in food-producing animals wear gloves when handling |
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Definition
synthetic broad spectrum used to treat bovine respiratory disease |
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Definition
can cause upset stomach erythomycin tylosin tilmicosin |
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Definition
bactericidal or bacteriostatic depending on concentration used to treat penicillin-resistant bacteria |
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Definition
used in livestock can be found in food/water additives not for use in horses |
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Definition
used to treat vocine respiratory disease |
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Definition
work against gram (+) bacteria Lincomycin clindamycin (Antirobe) often used for dental infections |
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Definition
deprive bacteria of essential material needed for metabolism |
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Definition
inhibit synthesis of folic acid / hinders growth of bacteria combined with trimethoprim & ormetoprim side effects - skin rash, crystalluria, KCS |
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Definition
sulfadimethoxine (albon) sulfadimethoxine/ormetroprim (primor) |
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Definition
interferes with bacterial nucleic acid |
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Definition
newer generation of quinolones identified by -floxacin ending in generic name can cause cartilage defects in frowing dogs given at high doses, can cause blindness in cats effective against gram + and gram - bacteria |
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Term
flouroquinolones (examples) |
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Definition
enrofloxacin (baytril) ciprofloxacin (cipro) orbifloxacin (orbax) marbofloxacin (zeniquin) |
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Definition
broad spectrum less potent than other antibiotics prohibited from use in food animals b/c may induce carcinogenic residues in animal tissue |
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Definition
nitrofurazone nitrofurantoin |
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Definition
antibacterial & antiprotozoal properties commonly used to treat diarrhea metronidazole (flagyl) |
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Definition
broad spectrum used primarily w/ erythromycin to treat infections in foals may cause reddish color to urine, tears, sweat, & saliva |
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Definition
divided into molds & yeast |
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Term
Superficial fungal infections |
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Definition
diagnosed through test media or microscopic identification |
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Term
Systemic fungal infections |
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Definition
identified through serology |
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Term
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Definition
polyene imidazole antimetabolic superficial |
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Term
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Definition
bind to fungal cell membrane nystatin (panalog)-administered topically, orally, IV Amphotericin B - administered IV, topically, extremely nephrotoxic |
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Term
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Definition
cause leakage of fungal cell membrane have fewer side effects than amphotericin b identified by -azole ending in generic name |
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Term
Imidazole antifungals (examples) |
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Definition
ketoconazole miconazole itraconazole fluconazole (treats valley fever) |
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Term
antimetabolic antifungals |
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Definition
given orally & topically in combination with other antifungals to treat cryptococcus infections Flucytosine |
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Definition
Griseofulvin - treats dermatophyte infections (ringworm) Lufeneron (Program) |
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Term
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Definition
limited use in vet med work by preventing viral penetration of the host cell inhibiting virus production of RNA or DNA |
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Term
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Definition
Acyclovir - used to treat ocular feline herpes virus Tamiflu - sometimes used to treat parvo Interferon - used to treat FeLV & ocular feline herpes |
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Definition
kills or inhibits growth of mocroorganisms on inanimate objects |
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Definition
kills or inhibits growth of microorganisms on living tissue |
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Definition
chemical that kills microorganisms |
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Definition
chemical that kills bacteria |
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Definition
chemical that kills viruses |
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Definition
chemical that kills fungi |
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Term
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Definition
chemical that kills spores which are especially resistant to chemicals |
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Term
Types of disinfecting agents |
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Definition
Phenols Quaternary Ammonium Compounds Aldehydes Ethylene oxide Halogens Biguanides Other |
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Definition
first antiseptic effective against Gram + bacteria & some Gram - bacteria, fungi, & some enveloped viruses Not effective vs. spores & nonenveloped viruses (such as parvo) Should not be used as an antiseptic due to skin irritation & possible neurotoxicity LYSOL |
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Term
Quaternary Ammonium Compounds |
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Definition
Effective vs. Gram + & Gram - bacteria not effective vs spores limited effectiveness vs fungi effective vs enveloped viruses but not nonenveloped viruses (such as parvo) Usually not irritating to skin Example : Roccal-D |
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Definition
Gluteraldehydes used to disinfect instruments in cold sterilization & on fiberoptics Sporicidal |
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Definition
used to disinfect instruments in gas or solution can be used as tissue fixation agent |
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Definition
gas used for chemical sterilization |
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Definition
used on Gram + and Gram - bacteria used vs. enveloped viruses not for antiseptic purposes causes pain and has denaturing effect on proteins usually 70% solution used |
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Definition
halogen kills bacteria, fungi, viruses, & spores found in bleach, usually used in a 1:10 dilution |
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Definition
halogen usually mixed with water or alcohol to form brown solution commonly used as topical antiseptics Betadine Povidine |
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Definition
effective vs. bacteria, some fungi, & enveloped viruses |
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Definition
kills anaerobic bacteria in deep wounds limit use - can cause damage to tissue |
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Definition
limited bactericidal activity main function is mechanical removal of microbes |
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Definition
live on the surface of the host cause external parasite infestations |
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Definition
parasites live inside the body cause internal parasite infections |
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Term
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Definition
worms found primarily in GI tract, liver, lungs, circulatory system |
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Definition
slender, tube-like, non-segmented transmitted by arthropods roundworms (ascarids, trichurs, ancylostoma, strongyle, dirofilaria) |
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Definition
can live in GI tract or other body tissues cestodes - tapeworms (taenia, dipylidium, echinococcus trematodes - flukes (paragonimus) |
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Definition
categorized by the type of parasite they work against |
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Definition
kill worm parasites further categorized into - antinematodal, anticestodal, antitrematodal |
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Term
Antinematodal - Benzimidazoles |
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Definition
Interfere with worm's energy metabolism given PO in repeated doses |
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Definition
ascarids & strongyles also has antifungal & anti-inflammatory effects Tresaderm Otic |
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Term
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Definition
horse dewormer can cause lier toxicity in dogs EQ Equine Wormer Paste |
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Definition
Ascarids, hookworms, & cestodes in horses dogs Telmintic |
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Definition
nematodes, hookworms, whipworms, taenia, giardia used in small animals, horses, & food animals not for use in lactating dairy animals Panacur |
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Definition
probiotics which are metabolized in the animals body to benzimidazole Febantel - Drontal Plus |
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Definition
anticholinergic to paralyze the parasite treat ascarids, strongyles, whipworms, & hookworms not ovicidal Levamisole - Levasole |
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Definition
cholinergic agonists that mimic action of Ach - initial stimulation and paralysis of the worm Examples: Pyrantel Pamoate (Nemex, Strongid-T) Pyrantel tartrate Morantel tartrate |
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Definition
used vs. both endoparasites & ectoparasites horses - bots, nematodes, strongyles,pinworms ruminants - strongyles dogs/cats - hookworms, nematodes, whipworms usually given as feed additive to cattle USE WITH CAUTION IN ALL SPECIES neurotoxic to parasites, can cause neurologic side effects in host animal Examples: dichlorvos (Task), Coumaphos (Baymix) |
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Definition
only eradicates ascarids in all species essentially nontoxic, sold OTC Examples: Hartz Health Measures Once-a-month Wormer |
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Definition
causes paralysis & death in the parasite Ivermectin - can cause adverse reaction in collies and collie crosses "White feet do not treat" Examples: Heartgard, Ivomec |
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Definition
consist of a head (scolex), neck & segments (proglottids) increase in length by producing new segments from the neck area (oldest segments are at the distal end of the worm) attaches to intestinal wall by its scolex (must dislodge it as part of treatment) Examples: Praziquantel, Droncit, Epsiprantel (Cestex), Fenbendazole |
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Definition
Named for the area they infect Have intermediat host, usually a snail Examples: Clorsulon (Curatrem), Albendazole (Valbazen), Praziquantel |
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Definition
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Definition
protozoa that cause various intestinal disorders, some serious, even fatal complex life cycle making them difficult to treat treatment includes sanitation & disinfection of environment |
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Term
Anticoccidials - SULFA drugs |
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Definition
work at various stages of coccidian life cycle usually given orally in feed, water, or by liquid and tablets |
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Definition
used in poultry, dogs, and cats reduces the number of oocysts shed |
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Definition
Corid coccidiosis in calves |
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Definition
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Definition
Deccox used in cattle and goats |
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Definition
protozoan parasite seen in animals treated with - Metronidazole (Flagyl), Fenbenazole (Panacur), Albendazole |
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Definition
blood protozoan transmitted by ticks treated with imidocarb (imizol) not used in food-producing animals |
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Definition
affects dogs, cats, ferrets caused by the nematode dirofilaria immitis transmitted by mosquitos adults live in the pulmonary artery but can be found in RT ventricle and RT atrium |
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Term
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Definition
L3 can be prevented from reaching maturity by the use of preventative medicines when given to a HW neg. dog the drug will prevent any larvae transmitted by a mosquito from reaching the adult stage when given at hight doses it will also kill circulating microfilariae in HW pos dogs |
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Definition
monthly preventative, given orally also used to treat demodex when given with pyrantel pamoate=Heartgard Plus Dose determines use - Low - HW preventative Moderate - kills microfilariae high - kills most internal parasites |
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Milbemycin (interceptor, Sentinel) |
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Definition
monthly preventative both products are also effective vs. hookworms, nematodes, and whipworms Sentinel also contains lufenuron for flea control |
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Definition
monthly preventative applied topically and absorbed systemically also controls fleas, ear mites, sarcoptic mange some tick preventative activity |
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Term
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Definition
six month injection interrupts early larval development was taken off the market, but available again |
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Definition
arsenical drug given IM in epaxial muscles between L3 & L5 |
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Term
Thiacetarsamide (caparsolate) |
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Definition
rarely used anymore, if at all |
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Term
adulticides - heartworm medications |
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Definition
used to treat any adult heartworms that may have developed in the RV because of improper or no preventatives |
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Term
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Definition
given at a higher dose need to monitor for neurolofic side effects |
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Definition
live on the outside of the body - flies, grubs, lice, fleas, mites, ticks, mosquitoes accurate id of the ectoparasite is essential for proper treatment can be oral, sprays, dips, pour-ons, ear tags, spot-ons, shampoos, dusts, foggers always read product lave and use proper protective gear |
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Definition
initial defense physical barriers (skin), mucus production, inflammation, fever, phagocytosis of foreign material |
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Term
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Definition
defense vs. specific antigen B and T-lymphocytes four types Active, passive, natural, artificial |
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Term
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Definition
arises when an animal receives an antigen that activates b and t-lymphocytes and causes the animal to produce antibodies takes time to develop, but lasts a relatively long time due to memory |
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Term
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Definition
arises when an animal receives antibodies from another animal provides immediate protection, but for a shorter amount of time |
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Definition
acquired during normal biological experiences |
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Definition
acquired through medical procedures |
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Term
vaccines trigger specific immune responses to help fight future infections from a specific agent |
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Definition
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Term
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Definition
suspension of weakened, live, or killed microorganisms administered to prevent, improve or treat an infectious disease |
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Term
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Definition
inactivated (killed) attenuated (modified-live) live recombinent toxoids antitoxins antiserum autogenous multiple-antigen vaccines |
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Term
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Definition
made from microorganisms or their components that have been chemically treated to kill the microorganism advantages - usually safe, stable and unlikely to cause disease disadvantages - need for repeated doses to ensure protection, adjuvant/preservatives may cause reaction |
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Term
attenuated (modified-live) |
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Definition
microorganisms have been altered to lose their virulence, but are still able to replicate w/in the animal to provide immunity advantages - immunity usually lasts longer, have better efficacy and quicker stimulation of CMI disadvantages - possible abortion when given to pregnant animal, can produce mild forms of the disease, can be shed into the environment |
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Term
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Definition
made from live microorganisms that may be fully virulent or avirulent advantages - fewer doses are needed to achieve immunity, lasts longer, adjuvants not needed, inexpensive disadvantages - possible residual virulence |
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Term
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Definition
a gene or part of a microorganism is removed from one organism (pathogen) and inserted into another microorganism advantages - fewer side effects, effective immunity, varied routes of administration disadvantages - increased cost |
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Term
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Definition
special type of vaccine used vs. toxins instead of microorganisms used like a vaccine provides active immunity disadvantages-shorter duration of effectiveness, may contain adjuvants/preservatives |
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Term
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Definition
substances that contain antibodies obtained from an animal that has been hypersensitized to neutralize toxins used when exposure to a toxin is likely provides passive immunity disadvantages- immunity short-lived, may also contain preservatives |
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Term
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Definition
antibody-rich serum from a hypersensitized or actually infected animal abs are collected from plasma short lived (passive) treats k9 distemper, feline panleukopenia, bovine anthrax |
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Term
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Definition
produced for a specific disease problem in a specific area from a sick animal cultured organism from farm disadvantages - may contain endotoxin or other byproducts so use with caution |
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Term
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Definition
multiple-antigen vaccines contain more than one antigen advantages-fewer injections to administer, less expensive when giving multiple vaccine agents disadvantages- rate of adverse reactions rise as the number of antigens goes up |
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Term
care and handling of vaccines |
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Definition
sensitive to sunlight, excessive heat and freezing store in refrigerator obtain from a reputable source some vaccines need to be reconstituted prior to use, use only diluent provided by manufacturer administer only via route identified by manufacturer (especially important in food animals) do not mix multiple vaccines together in same syringe administer different vaccines in different sites and record where/how given |
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Term
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Definition
age health medications pregnancy environment history |
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Term
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Definition
pain, swelling at injection site |
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Term
systemic vaccine reaction |
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Definition
anaphylaxis, hives, wheezing, dyspnea, hypotension, shock |
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Term
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Definition
tumors of connective-tissue origin |
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Term
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Definition
way to assess the level of antibody to particular antigen expressed in ratios such as 1:2, 1:4 the correlation between antibody titer and protection vs. exposure to the disease has not been thoroughly investigated |
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Term
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Definition
recommended for all individual animals because: the consequences of infection are severe infection poses zoonotic potential disease prevalence is high organism is easily transmitted to others of its species vaccine is safe and efficacious examples: rabies, DHPP, FRCP |
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Term
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Definition
recommended only for individual animals deemed to be at high risk for contact with the organism based on evaluation of all risk factors Example: Bordetella |
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Term
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Definition
antineoplastic and chemotherapeutic agents stop the cancerous activity of malignant cells |
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Term
act vs. characteristics unique to malignant cells |
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Definition
rapid cell division different rate of cellular drug uptake increased cellular response to selected anticancer drugs |
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Term
Cell-cycle nonspecific (CCNS) |
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Definition
antineoplastic agents that act during any phase of the cell cycle kill the cell during the dividing or resting phases |
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Term
cell-cycle specific (CCS) |
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Definition
antineoplastic agents that act during a specific phase of the cell cycle effective against rapidly growing cancer cells |
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Term
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Definition
the percentage of the cancer cells that are actively dividing high growth fraction = cells are dividing rapidly low frowth fraction = cells are dividing slowly |
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Term
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Definition
time required for the number of cancer cells to double |
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Term
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Definition
kill at any phase concentration dependent killing Cyclophosphamide (Cytoxan) Cisplatin Caboplatin Doxorubicin (adriamycin) steroids - corticosteroids, estrogens, androgens |
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Term
CCS - cell-cycle specific |
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Definition
kill in specific phases of cell cycle; killing is time dependent 5-fluorouracil vincristine vinblastine |
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Term
administering antineoplastics |
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Definition
various protocols are used-some in therapeutic combinations the tumor is more effectively destroyed when bombarded w/drugs that act in different ways calculation of antineoplastics is based on body surface area BSA is determined from bodyweight in kg using charts |
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Term
safe handling of antineoplastics |
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Definition
waste is considered contaminated for 72 hr and disposed of properly reconstitution of agents is done in a vertical airflow hood with PPE IV catheter placement must be a "good stick" and some area not used again w//in a 24 hour period Pregnant women should not handle antineoplastics immuno-compromised people should not handle antineoplastics NO eating/drinking while handling drugs |
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Term
immune enhancers biologic response modifiers (BRMs) |
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Definition
agents used in conjunction with antineoplastic agents to enhance body's immune system |
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Term
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Definition
group of naturally-occurring proteins that have antitumor and antiviral effets |
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Term
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Definition
group of chemicals that play various roles in the immune system |
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Term
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Definition
chemical used in treatment of fibrosarcomas and MCTs (mast cell tumors) in dogs and cats stimulates macrophage activity |
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Term
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Definition
identical immunoglobulin molecules that have cytotoxic effects on tumor cells |
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Term
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Definition
work mainly by interfering with one of the stages of the cell cycle or by affecting cell messengers Used primarily to treat immune-mediated disorders in which the immune system is overactive Examples: Cyclosporine (Atopica, Optimmune) Azathioprine (Imuran) Cyclophosphamide (Cytoxan) |
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Term
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Definition
works by making asparagine unavailable to malignant cells |
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Term
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Definition
controls the growth of tumor cells Toceranib (Palladia)- treats Grade II and III, recurrent, cutaneous mast cell tumors in dogs, given in tablet form, owners should wear gloves and wash hands |
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Term
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Definition
bone marrow suppression GI effects alopecia infertility cardiotoxicity |
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Term
opthalmic drug considerations |
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Definition
1-drug penetration-topical opthalmic drugs tend to be absorbed into the anterior chamber and have little effect on the posterior or vitreous chambers 2-frequency of drug application-ointments are usually administered less frequently than eye drops 3-ease of application-some clients find ointments easier to apply than drops and vice cersa |
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Term
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Definition
used for foreign body removal and performance of comprehensive eye exams Examples: proparacaine, tetracaine |
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Term
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Definition
detects corneal defects and patency of lacrimal ducts |
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Term
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Definition
cholinergic drugs that constrict the pupil lower introcular pressure by increasing outflow of aqueous humor used for glaucoma Example - Pilocarpine |
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Term
Pupil Opening (Mydriatics) |
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Definition
drugs that dilate pupils may be used to treat uveitis and to dilate pupil for fundic exam Examples: atopine, homatropine, phenylephrine, tropicamide, epinephrine |
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Term
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Definition
drugs that paralyze the ciliary muscles and may minimize pain due to ciliary spasm |
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Term
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Definition
disease characterized by increased IOP due to structural defects, genetic defects, or result of other ocular disease or trauma If left untreated, could cause blindness drugs to treat glaucoma reduce IOP by decreasing production of fluids w/i the eye Examples: carbonic anhydrase inhibitors, beta-adrenergic blockers, osmotic diuretics |
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Term
keratoconjunctivitis sicca (KCS, "dry eye") |
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Definition
tear production is decreased resulting in persistent mucopurulent conjunctivitis and corneal scarring and ulceration may be immune mediate treatment includes: artificial tears, antibiotic-steroid preparations, lacrimogenics (increase tear production), immunomodulators |
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Term
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Definition
inflammation of the pinna dna external auditory canal caused by bacteria, yeast, parasites, allergiew, systemic disease, and neoplasia clinical signs = head shaking, ear scratching, ear discharge |
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Term
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Definition
inflammation of the middle ear caused by extension of otitis externa through ruptured tympanum, URI, polyps, trauma can be clinically silent or have signs similar to otitis externa |
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Term
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Definition
inner ear infection signs = head tilt toward the affected side, ataxia, nausea, and vomiting |
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Term
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Definition
otoscopic exam ear cytology culture / sensitivity |
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Term
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Definition
combo of antifungal, antibiotic, and antiinflammatory antiparasitics are used to treat ear mites local anesthetics reduce pain cleansers, drying agents and cerumen (ear wax) dissolvers are used in combo with otic medications |
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Term
Otic Medications (examples) |
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Definition
Tresaderm Otomax, Mometamax Panalog Baytril Otic Conofite MilbeMite |
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