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VT 150 Pharmacology Ch 7,8,9,12,16,22
VT 150 Pharmacology Ch 7,8,9,12,16,22
115
Pharmacology
Undergraduate 3
11/11/2014

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Term
Neuron
Definition
The basic unit of the nervous system.
Term
Sensory, Associative, Motor
Definition
What are the three types of nerurons?
Term
Sensory
Definition
This neuron carries impulses towards the CNS.
Term
Associative
Definition
This neuron carries impulses from one neruron to another.
Term
Motor
Definition
This neuron carries impulses away from the CNS.
Term
brain + spinal cord
Definition
Where is the anatomical location of the Central Nervous System. (CNS)
Term

cranial nerves & spinal nerves

 

Definition
Where is the anatomical location of the peripheral nervous system. (PNS) ?
Term
Autonomic Nervous System
Definition
The function of this system is to control smooth muscle, cardiac muscle, and endocrine glands with out conscious control.
Term
Somatic Nervous System
Definition
The function of this system is to conciously or voluntarily control skeletal muscle.
Term
Sympathetic Nervous System
Definition
This system is termed the "fight or flight" system It will cause RR, and HR to increase, pupil dilation, and GI function to decrease.
Term
Acetylcholine
Definition
This neurotransmitter is released at the preganglionic synapse.
Term
Alpha-1
Definition
This receptor, located in the smooth muscles of blood vessels, causes constriction of arterioles (except in the GI tract) which causes BP to increase.
Term
Alpha-2
Definition
Found in post-ganglionic sympathetic nerve endings, the function of this receptor is to decrease release of norepinephrine causing constriction of skeletal muscles. BP will decrease.
Term
Beta-1
Definition
This receptor, located in the heart, causes an increase in HR, conduction (electric signal) & contractility.
Term
Beta-2
Definition
This receptor, found in the smooth muscle of the lungs, causes dilation of skeletal blood vessels.
Term
Dopaminergic
Definition
This receptor, located in renal, mesenteric, & cerebral arteries, causes dilation of coronary vessels, renal blood vessels, and mesenteric bllod vessels.
Term
parasympathetic nervous system
Definition
This system is termed the "homeostatic system". it will return RR, HR, and blood flow to normal. Found in the brainstem region.
Term
Acetylcholine
Definition
This neurotransmitter is release at both pre- and post-ganglionic synapses in the PNS.
Term
Muscurinic
Definition
This receptor, located in the PNS, stimulates smooth muscle and slows HR.
Term
Nicotinic
Definition
This receptor, found in the PNS, affects skeletal muscle.
Term
Anticonvulsants
Definition
These drugs help prevent the occurrence of seizure activity by suppressing the abnormal electrical impulses, but do not eliminate the cause of seizures.
Term
Ataxia, drowainess, & hepatoxicity
Definition
The side effects of CNS depressants such as anticonvulsants are:
Term
Phenobarbital
Definition
This long-acting barbiturate depresses motor centers of the cerebral cortex. Impairs transmission of impulses across the synapse in the brainstem-inhibiting communication. C-IV controlled substance.
Term
Orally or IV.
Definition
What routes are available for Phenobarbital administration?
Term
Pentobarbital
Definition
This short-acting barbiturate is a C-II controlled substance administered IV. It can cause irritation if given perivascularly. Seen commonly in euthenasia solution.
Term
respiratory depression & hypothermia.
Definition
Side effects of Pentobarbital.
Term
Primidone
Definition
This drug is similar to phenobarbital structurally. given PO, and can induce liver enzymes that raise its own & other drug metabolism.
Term
Diazepam (Valium)
Definition
C-IV controlled subatsnace used for status epilepticus (IV) and then followeed by PO therapy. Increases GABA
Term
Clorazepate
Definition
C-IV controlled substance. Used orally for adjunct anticonvulsant therapy & behavior phobias. Side effects include sedation and ataxia.
Term
Potassium Bromide (KBr)
Definition
Used as adjunct anticonvulsant therapy. Takes several days to reach therapeutic state. Loading dose then maintenece dose required. Side effects include elctrolyte imbalences.
Term
Valproic Acid
Definition
Oral anticonvulsant that increases blood levels of GABA. Limited use in vet med due to side effects. Blood work is necessary on this drug.
Term

Phenytoin (Dilantin)

 

Definition
Rarely used in vet med due to side effects. Anticonvulsants effects only noted after accumulation of doses.
Term
Tranquilizer
Definition
Calms animals; used to reduce anxiety and aggression.
Term
Sedative
Definition
Decreases irratability & excitment, may provide analgesic effects.
Term
Anti-anxiety
Definition
Lesson anxiousness but does not make the animal drowsy.
Term
Phenothiazine derivatives
Definition
These drugs block dopamine & alpha-1 receptors found in smooth muscle of peripheral blood vessels. They cause sedation and relieve fear. They do not cause analgesia. Commonly used prior to minor procedures or as pre-anesthetic agents.
Term
Phenothiazine derivatives
Definition
These types of drugs can cause paraphimosis (penile prolapse in horses).
Term
Benzodiazepines
Definition
These anti-anxiety drugs are C-IV controlled substances. They produce muscle relaxation and have some anti-convulsant activity. Sometimes used as appetite stimulants in cats. They do not provide analgesia. An example of this drug class is Diazepam.
Term
Flumazenil
Definition
Reversal agaent for benzodiazepines
Term
Alpha-2 Agonists
Definition
This drug class binds to alpha-2 receptors on neurons to prevent release of norepinephrine. They produce calming effects, some analgesia, and muscle relaxation. They decrease ability to respond to stimuli. An example is: Xylazine.
Term
Xylazine (Rompun)
Definition
This drug can be combined with ketamine for short term procedures in horses and cats. It produces analgesia in horses but vomitting in cats. It can slow insulin secretion which causes transient hyperglycemia.
Term
Yomhimbine
Definition
What is the reversal agenet for Xylazine (Rompun)?
Term
Detomidine (Domosedan)
Definition
This drug produces better analgesia in horses. Labaled for sedation in horses, but horses can still respond to stimuli.
Term
Medetomidine (Domitor)
Definition
Labled for sedation and analgesia in dogs over 12 weeks old. Used for minor surgical procedures and restraint. It initialy causes BP to rise and HR to lower. The IV and IM doses are different!
Term

Atipamezole (Antisedan)

 

Definition
Reversal agent for Medetomadine (Domitor)
Term
Narcotics
Definition
Opioid or opioid like substances that require a prescription. They work on the CNS. Used for moderate-severe pain in smooth muscle, organs, & bones.
Term
Non-narcotic
Definition
Less potent then narcotics, not addictive, and work on the PNS receptor sites.
Term
Opioids
Definition
Naturally obtained from the poppy plant. They produce analgesia and sedation, & relieve anxiety. They produce their action on opioid receptors located in nervous tissues. Cats and horses are very sensitive to them.
Term
Mu receptor (u)
Definition
Found in pain areas of the brain. Cause analgesia, euphoria, respiratory depression, & physical dependence.
Term
Kappa (k)
Definition
Found in cerebral cortex and spinal cord. Produce analgesia, sedation & miosis (constriction of pupils)
Term
Delta (o)
Definition
Found in the brain, this opioid receptor controls whinning, hallucinations, and struggling effects. May cause mydriasis (dilation of pupils)
Term
Mu, Kappa, Delta
Definition
What are the 3 opioid receptors?
Term
Opium
Definition
This drug can be used as an anti-diarrheal in calves. C-II controlled substance.
Term
Morphine sulfate.
Definition
C-II controlled substance that is a Mu agonist. Used for severe pain. Pre-anesthetic & anesthetic.
Term
Meperidine (Demerol)
Definition
C-II controlled substance that is a Mu agonist with a short duration of action. Used for acute pain. Extra-label use in animals. Pre-anesthetic.
Term
Hydromorphone (Dilaudid)
Definition

A C-II controlled substance that is a semi-synthetic opioid that is 5x more potent then morphine. Mu agonist. it is used post op to produce sedation & offset moderate-severe pain. Duration of action is 4 hours.

 

Term
Butorphanol (Torbugesic) (Torbutrol)
Definition
C-IV controlled substance, synthetic opioid with kappa and mu receptor activity. It is not a very strong analgesic. Short duration of action. Can be used as a analgesic, pre-anasthetic, & antitussive.
Term
Hydrocodone (Tussigon) (Hycodan)
Definition
C-III controlled substance, synthetic opioid, used as an antitussive. When combined with acetaminophen it makes Vicodin for use in humans.
Term
Fentanyl
Definition
C-II controlled substance that is a sunthetic opioid 200x more potent than morphine. Used as an analgesic/ tranquilizer & chemical restraint. Available as a transdermal patch.
Term
Buprenophine (Buprenex)
Definition
C-III controlled substance that provides long term analgesia (8-10 hours) Used post-op. Side effects are rae but include respiratory depression.
Term
Codeine
Definition
C-III controlled substance that is a synthetic opioid used as an antitussive in dogs. It can be combined with acetaminophen for pain relief in humans.
Term
Diphenoxylate (Lomotil)
Definition
C-V controlled substance that is a synthetic opioid. When combined with atropine it makes an antidiarrheal.
Term
Opioid antagonist
Definition
Known as narcotic antagonists, they block the binding of opioids to their receptors. Used to treat respiratory and CNS depression caused by opioid use. Given IV for rapid onset of action. Examples include Naloxone & Naltrexone
Term
Naloxone (Narcan)
Definition
This drug is given IV or IM and has a high affinity for mu receptors. It reverses Meperidine, morphine, & oxymorphone.
Term

Neuroleptanalgesics

 

Ex: Xylazine--> butorphanol

 

Acepromazine--> morphine

Definition
This class of drugs are a combination of an opioid & a tranquilizer or sedative. They cause CNS depression and analgesia. Opioid anatgainists can reverse their opioid effects. Veterinarians tend to make their own.
Term
Lidocaine
Definition
This local anesthetic is for topical use and injection.
Term
Proparacaine
Definition
This local anesthetic is for opthalmic use.
Term
tetracaine (Neo-Predel)
Definition
This local anesthetic is used topicaly applied to skin and can also be opthlamic or otic solution.
Term
Bupivicaine (Marcaine)
Definition
This local anesthetic has a longer onset and is used in epidurals and as oral nerve blocks.
Term
Barbiturates
Definition
CNS depressants used as anti-convulsants, anesthetics, & euthenasia solutions. Can be long or short acting. Can cause cardiovascular & respiratiry depression. Highly irritating to perivascular tissue.
Term
Thiopental
Definition
C-III controlled substance that is an ultra short acting thiobarbiturate. Lasts 5-30 minutes. Has to be reconstituted. Caution in sighthounds.
Term
Methohexital (Brevane)
Definition
C-III controlled substance that is an oxybarbiturate similar to ultra short acting thiobarbiturate. Used in sight hounds.
Term
Dissociatives
Definition
This class of drugs cause muscle rigidity, amnesia, and mild analgesia. Used only for restraint, diagnostic procedures and minor surgeries. Can cause minor cardiac stimulation, respiratory depression and exaggerated reflexes.
Term
Ketamine (Ketaset)
Definition
C-III controlled substance approved for use in primates and cats. Need to use an eye lubricant when in use. Usually used in combination with drugs like ace, xylazine, and/ or diazepam.
Term
Tiletamine (Found in Telazol)
Definition

This is a C-III controlled substance used as an approved anesthetic for dogs and cats. Pain at injection site usually occurs. IV, SQ, IM

 

Term
Ketamine/ Valium (Ket/ val)
Definition
Mixture prepared in clinics for IV induction using equal volumes. Best if prepeared just before injection.
Term
Propofol (Propoflo)
Definition
ultra short acting drug that produces a rapid, smooth induction when given IV. Caution needs to be taken in cats because it can only be given one time, it can not be in bolus due to the preservatives.
Term
Minimal alveolar concentraion (MAC)
Definition
Inhalation anesthetics are compared on this value which is minimal concentration of anesthetic that produces no responce to stimuli in 50% of patients.
Term
Blood-gas solubility
Definition
An inhalation anesthetic with a high______________, will have a longer induction/ recovery time because the agent must first saturate the blood before becoming available to tissues.
Term
Nitrous Oxide
Definition
This inhalation anesthetic is also called " laughing gas". It is stored in blue cylinders. Diffuses rapidly through the body filling hollow organs. Not reccomended for GDV, pneumothorax, or twisted intestines.
Term
Isoflurane (purple)
Definition
This inhalation anaesthetic is non-flamable which causes rapid induction and short recoveries. Planes of anestheisa can change rapidly.n Pre-medicating before use will allow for a smoother recovery. One of the most commonly used inhalation anesthetics in veterinary medicine.
Term
Seoflurane (yellow)
Definition
This is a non-flamable inhalation anesthetic with few cardiovascualr side effects. It enters the blood stream quickly and escapes to the brain. It is good for mask induction.
Term
Doxapram (Dopram)
Definition
This CNS stimulant stimulates the brainstem to increase respiration in animals with apnea. Used in neonates born via C-section.
Term

Methylxanthine

Ex: Theophyline (Theo-dur)

Aminophyline

Definition
This CNS stimulant is used a bronchodilator but can cause GI irritation.
Term
Inflammation
Definition
Natural responce of living tissue to injury or infection
Term
Pyrogen
Definition
A substance that can inititate a fever.
Term
Exogenous
Definition
A pyrogen that is caused by a forign substance such as bacteria or virus
Term
Endogenous
Definition
A pyrogen that is a chemical mediator inside the body such as prostaglandin.
Term
corticosteroids
Definition
Hormones that are produced by the adrenal cortex in response to ACTH secretion by anterior pituitary. Raises BG.
Term
Steroidal Anti-inflammatories
Definition
These drugs block the action of the enzyme phopholipase which is an enzyme that damages cell membranes.
Term
Glucocorticoid drugs
Definition
These drugs are potent anti-inflammatories that treat conditions such as: allergic responses, pruritis, anaphylaxis. and inflammatory conditions such as: autoimmune disease, shock, occular inflammation, and spinal cord inflammation.
Term
Autonomic nervous system drugs
Definition
These drugs work by acting like neurotransmitters or interfering with neurotransmitter release. They affect the parasympathetic or sympathetic nervous system.
Term

2.54 centimeters

 

Definition
1 inch is equal to how many centimeters.
Term
2.2l bs
Definition
1 kilogram is equal to how many pounds
Term
16 ounces
Definition
1 pound is equal to how many ounces
Term
65 miligrams
Definition
1 grain is equal to how many miligrams
Term
28.35 grams
Definition
1 ounce is equal to how many grams
Term
15.4 grains
Definition
1 gram is equal to how many grains
Term
8 fluid ounces
Definition
1 cup is equal to how many ounces.
Term
Approximately 30 mililiters
Definition
1 ounce is equal to how many mililiters
Term
1 cubic centimeter.
Definition
1 mililiter is equal to how many centimeters
Term
5 mililiters
Definition
1 teaspoon is equal to how many miiliters
Term
Metoclopramide (Reglan)
Definition
This cholinergic drug controls vomitting and aids in gastric emptying.
Term
Pilocarpine
Definition
This cholinergic drug is used in opthalmic solutions to decrease intraoccular pressure seen in glaucoma.
Term
Atropine
Definition
This anticholinergic drug is used as a pre-anesthetic to prevent bradycardia, it decreases salvation, dilates pupils, controls cilary responce, and decreases GI motility.
Term
Glycopyrolate (Robinul)
Definition
This anticholinergic drug is similar to atropine but has a longer duration. Used to treat bradycardia.
Term
Aminopentamide (Centrine)
Definition
this anticholinergic drug is used to control diarrhea and vomitting.
Term
Adrenergic drugs
Definition
These drugs stimulate the action of the sympathetic nervous system by working on the adrenergic receptors located in smooth muscle.
Term
Epinephrine
Definition
Naturally occuring catecholamine that affects alpha-1, beta-1, and beta-2 receptors. Used in ER situations for cardiac resuscitation.
Term
Norepinephrine
Definition
Naturally occuring catecholamine that is an injectable drug used to increase blood pressure.
Term
Dopamine
Definition
Adrenergic drug used to treat shock, & congestive heart failure.
Term
Dobutamine
Definition
Adrenergic drug used to treat heart failure.
Term
Phenylpropanolamine (PPA) (Proin)
Definition
Adrenergic drug used to treat urinary incontinence
Term
Albuterol/ Terbutaline
Definition
Adrenergic drug used to treat brochospasm by producing bronchodilation.
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