Term
| what can increase HDL levels when combined with simvastatin? |
|
Definition
|
|
Term
| what can inhibit the incorporation of riboflavin into FAD and FMN? |
|
Definition
| Chlorpromazine, tricyclic antidepressants, quinacrine, adriamycin |
|
|
Term
| what drug increases destruction of riboflavin by liver enzymes? |
|
Definition
|
|
Term
| what can inhibit the conversion of thiamine to thiamine pyrophosphate? |
|
Definition
|
|
Term
| what can displace vitamin B6 from protein binding sites? |
|
Definition
| Anticonvulsants (Carbamazepine) |
|
|
Term
| these can act as a vitamin B6-antagonists, producing its inactive metabolites |
|
Definition
|
|
Term
| Vitamin ___ is an antidote for isoniazide-induced neurotoxicity |
|
Definition
|
|
Term
| there will be marked reduction in seizure activity by anticonvulsants (phenytoin) when combined with this vitamin |
|
Definition
|
|
Term
| what can impair the conversion of B6 to pyridoxine-5-phosphate? |
|
Definition
|
|
Term
| Vitamin ___ increases the analgesic and anti-inflammatory activity when combined with NSAIDs |
|
Definition
|
|
Term
| _____ and _____ can result in depletion of folate by inhibiting folate absorption? |
|
Definition
| Ethanol and oral contraceptives |
|
|
Term
| what drugs are folate antagonists? |
|
Definition
| sulfasalazine/trimethoprim |
|
|
Term
| what drugs can develop folate deficiency by impairing metabolism? |
|
Definition
| phenytoin, phenobarbital, phenothiazine, and primidone |
|
|
Term
| what can decrease plasma B12 levels? |
|
Definition
| long term use of proton pump inhibitors |
|
|
Term
| what medications inhibit B12 absorption from food? |
|
Definition
| Metformin, neomycin, cholestyramine, chloramphenicol, and colchicine |
|
|
Term
| what blocks the action of warfarin? |
|
Definition
|
|
Term
| this drug can result in decreased serum levels of 1,25-dihydroxy vitamin D (due to inhibition of 25(OH)-vitamin D3-1-hydroxylase enzyme) |
|
Definition
|
|
Term
when combined with calcium, which of the following results in an increased rick of developing hypercalcemia?
a) digoxin
b) levothyroxine
c) hydrochlorothiazide |
|
Definition
|
|
Term
when combined with calcium, which of the following can increase the likelihood of arrhythmias?
a) fosamax
b) digoxin
c) hydrochlorothiazide |
|
Definition
|
|
Term
when combined with calcium, which of the following decreases the absorption of calcium? (more than one answer)
a)digoxin
b)tetracycline
c) omeprazole
d) mineral oil and stimulant laxatives |
|
Definition
| omeprazole, mineral oil, and stimulant laxatives |
|
|
Term
when combined with calcium, which of the following can result in decreased drug absorption? (more than one answer)
a) omeprazole
b) ciprofloxacin
c) tetracycline
d) fosamax
e) levothyroxine
f) prednisone |
|
Definition
| tetracycline, ciprofloxacin, fosamax, levothyroxine |
|
|
Term
when combined with calcium, the use of this drug (when used for months) can cause calcium depletion which leads to osteoporosis:
a) fosamax
b) prednisone
c) tetracycline
d) omeprazole |
|
Definition
|
|
Term
T/F?
magnesium hydroxide interferes with the absorption of folic acid and iron |
|
Definition
|
|
Term
T/F?
concomitant administration of zinc supplements and cetain antibiotics (tetracyclines and quinolones) may decrease absorption of the antibiotics and potentially reduce their efficacy |
|
Definition
|
|
Term
T/F?
concurrently administered oral calcium supplement decreases the absorption of tetracycline, ciprofloxacin, and levothyroxine |
|
Definition
|
|
Term
T/F?
iron supplements may result in decreased absorption and efficacy of levothyroxone and tetracyclines |
|
Definition
|
|
Term
T/F?
glucocorticoids (such as prednisone) can cause hypercalcemia leading to cardiac arrhythmias |
|
Definition
|
|
Term
T/F?
orally administered magnesium decreases the absorption of tetracycline |
|
Definition
|
|
Term
T/F?
thiazide diuretics increase the risk of developing hypercalcemia |
|
Definition
|
|
Term
T/F?
patients with severe chronic kidney disease are advised to avoid overconsumption of milk of magnesia |
|
Definition
|
|
Term
T/F?
calcium supplements increase the likelihood of arrhythmias in people taking digoxin for heart failure |
|
Definition
|
|
Term
T/F?
mineral oil and stimulant laxatives increase intestinal calcium absorption |
|
Definition
|
|
Term
T/F?
H2-blockers and proton pump inhibitors (omeprazole) may decrease the absorption of calcium citrate |
|
Definition
|
|
Term
T/F?
aluminum containing (not magnesium containing) antacids increase urinary excretion of calcium |
|
Definition
|
|
Term
T/F?
long term administration of certain diuretics may result in the hypermagnesimia |
|
Definition
|
|
Term
T/F?
oral calcium supplement may enhance the action of calcium channel blockers |
|
Definition
|
|
Term
T/F?
Combination of simvastatin (Zocor) and niacin inhibits the progression of
coronary artery stenosis and decreases the frequency of cardiovascular events by
decreasing LDL level. [Note: HDL is replaced with LDL] |
|
Definition
|
|
Term
T/F?
Concurrent therapy with vitamin C, vitamin E, selenium, and beta-carotene
enhanced the protective effects of the simvastatin-niacin combination. |
|
Definition
|
|
Term
T/F?
Coadministration of nicotinic acid with lovastatin may result rhabdomyolysis. |
|
Definition
|
|
Term
T/F?
Niacin supplementation is required during long-term treatment with isoniazid or 5-fluorouracil. |
|
Definition
|
|
Term
T/F?
Niacin deficiency may result during long-term treatment with isoniazid or 5-fluorouracil. |
|
Definition
|
|
Term
T/F?
Oral contraceptives inhibit folate absorption. |
|
Definition
|
|
Term
T/F?
Intake of large doses of vitamin C may synergistically increase the effects of
warfarin. |
|
Definition
|
|
Term
T/F?
Rifampin decreases plasma vitamin D levels. |
|
Definition
|
|
Term
T/F?
Use of vitamin E supplements may decrease the risk of bleeding with Coumadin therapy. |
|
Definition
|
|
