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Vitamins and Minerals
Vitamin/Mineral Functions, Toxicities and Deficiencies, and RDA
107
Nutrition
Undergraduate 2
04/01/2015

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Term
Vitamin A Function
Definition
Helps maintain good vision (night vision); resistance to infections; helps with growth and repair of body tissues.
Term
Vitamin A RDA
Definition
10,000 IU's (~900 ug)
Term
Vitamin A Toxicity
Definition
Osteoporosis(inhibits Vitamin D uptake); birth defects; yellow skin.
Term
Vitamin A Deficiency
Definition
Skin becomes dry and scaly; risk of infectious disease; Blindness.
Term
Vitamin D Function
Definition
Helps with bone formation and bone maintenance; Regulation of absorption of Calcium and Phosphorus.
Term
Vitamin D RDA
Definition
600 IU's (~15 ug)
Term
Vitamin D Toxicity
Definition
Formation of stones in soft tissues; hardened blood vessels.
Term
Vitamin D Deficiency
Definition
Causes insufficiency of Calcium, leading to Osteoporosis in adults and Rickets in children.
Term
Vitamin E Function
Definition
Antioxidant that protects Vitamin A and fatty acids from oxidation; Helps maintain cell membranes; red blood cell integrity.
Term
Vitamin E RDA
Definition
15 mg
Term
Vitamin E Toxicity
Definition
Interference with Vitamin K absorption leading to hemorrhaging.
Term
Vitamin E Deficiency
Definition
Fat malabsorption; Erythrocyte hemolysis; Neuromuscular dysfunction.
Term
Vitamin K Function
Definition
Create factors needed for blood clotting.
Term
Vitamin K RDA
Definition
90 ug
Term
Vitamin K Toxicity
Definition
Reduce effectiveness of anticoagulant drugs like Warfarin or Coumadin.
Term
Vitamin K Deficiency
Definition
Hemorrhaging can occur; Fat malabsorption.
Term
What are fat-soluble vitamins?
Definition
Vitamins that are dissolved into fat and stored in fat for later retrieval and use by the body. Vitamins A, D, E, and K are all fat-soluble vitamins.
Term
Vitamin B1 (Thiamin) Function
Definition
Energy metabolism (TCA cycle)
Term
Vitamin B1 (Thiamin) RDA
Definition
1.2 mg/day men
1.1 mg/day women
Term
Vitamin B1 (Thiamin) Toxicity
Definition
No adverse effects
Term
Vitamin B1 (Thiamin) Deficiency
Definition
Wernicke-Korsakoff syndrome (Alcoholics)
Beriberi: Dry- Muscle weakness in arms and legs
Wet- Cardiovascular Problems
Term
Vitamin B2 (Riboflavin) Function
Definition
Serves as a coenzyme in energy metabolism (FAD electron carrier).
Term
Vitamin B2 (Riboflavin) RDA
Definition
1.3 mg/day men
1.1 mg/day women
Term
Vitamin B2 (Riboflavin) Toxicity
Definition
No UL
Term
Vitamin B2 (Riboflavin) Deficiency
Definition
Inflammation of membranes (eyes, skin, mouth, GI tract).
Term
Vitamin B3 (Niacin) Function
Definition
Serves as a coenzyme in energy metabolism (NAD electron carrier).
Term
Vitamin B3 (Niacin) RDA
Definition
Naturally synthesized by tryptophan in the body (60 mg tryp. for 1 mg niacin). RDA is stated in the niacin equivalents (NE).
Term
Vitamin B3 (Niacin) Toxicity
Definition
Naturally occurring niacin= No harm
Supplementation= Niacin flush can occur
Term
Vitamin B3 (Niacin) Deficiency
Definition
Pellagra- skin changes to a darker color and flakes away.
Term
Pantothenic Acid Function
Definition
Part of the chemical structure of Coenzyme A (COA). COA is used in the oxidation of pyruvate during the TCA cycle and is used for oxidation of fatty acids for energy.
Term
Pantothenic Acid (Vitamin B5) RDA
Definition
AI (5 mg/day both men and women).
Term
Pantothenic Acid (Vitamin B5) Toxicity
Definition
No known toxicity. Only adverse effect was diarrhea after extremely high doses (10-20g).
Term
Pantothenic Acid (Vitamin B5) Deficiency
Definition
Very rare and only found in serious cases of malnutrition. Would cause painful burning and tingling sensations in the feet.
Term
Vitamin B6 (Pyridoxine) Function
Definition
Converted to coenzymes for amino acid metabolism, urea metabolism, conversion of tyrosine to niacin or serotonin, and synthesis of heme nucleic acids. Can be stored in muscle tissue.
Term
Vitamin B6 (Pyridoxine) RDA
Definition
1.3 mg/day for adults
Term
Vitamin B6 (Pyridoxine) Toxicity
Definition
Irreversible nerve damage
Term
Vitamin B6 (Pyridoxine) Deficiency
Definition
Scaly dermatitis, anemia. Alcohol contributes to the destruction of B6.
Term
Folic Acid (Vitamin B9) Function
Definition
Primary coenzyme form of THF. THF transfers single-carbon compounds during metabolism, which is important for: DNA synthesis, Conversion of B12 to a conenzyme, and regenerating methionine and homocysteine.
Term
Folic Acid (Vitamin B9) RDA
Definition
400 ug/day for adults
600 ug/day for pregnant women
Term
Folic Acid (Vitamin B9) Toxicity
Definition
Stomach problems, sleeping problems, skin reactions, and seizures can occur.
Term
Folic Acid (Vitamin B9) Deficiency
Definition
During pregnancy, without proper Folate intake by the mother, a fetus can form a disorder called Spina Bifida. In adults it can cause anemia and GI tract deterioration.
Term
Vitamin B12 (Cobalamin) Function
Definition
Used with folic acid in DNA and RNA synthesis, and is used to regenerate methionine and homocysteine. Also used in formation of blood cells.
Term
Vitamin B12 (Cobalamin) RDA
Definition
2.6 ug/day for adults
Term
Vitamin B12 (Cobalamin) Toxicity
Definition
No known Toxicity and UL
Term
Vitamin B12 (Cobalamin) Deficiency
Definition
Muscle weakness, difficulty walking, numbness or tingling in extremities, neurological symptoms.
Term
Vitamin C (Ascorbic Acid) Function
Definition
Antioxidant that protects against free radicals; Protects tissues from oxidative stress (disease prevention); enhances iron absorption.
Term
Vitamin C (Ascorbic Acid) RDA
Definition
90 mg/day men
75 mg/day women
Term
Vitamin C (Ascorbic Acid) Toxicity
Definition
Diarrhea, GI distress, and can interfere with medical regimens.
Term
Vitamin C (Ascorbic Acid) Deficiency
Definition
Scurvy- Gums bleed easily, Capillaries under skin break easily, and psychological symptoms can arise. Death could also occur if not treated.
Term
What are Water-Soluble Vitamins?
Definition
Vitamins that can dissolve in water and are usually not stored by the body (except B6). Excess is eventually excreted through urine. The 8 B-complex vitamins and Vitamin C are all these type of vitamin.
Term
What are Minerals?
Definition
Inorganic substances used as cofactors by the body and usually used along with vitamins to help enzymes carry out reactions.
Term
Sodium Function
Definition
Nerve impulse transmission; muscle contractions; Acid-Base regulation; Primary regulator of extracellular fluid.
Term
Sodium RDA
Definition
2400 mg/day for adults
Term
Sodium Toxicity
Definition
Acute= edema and high blood pressure
Chronic= Hypertension
Term
Sodium Deficiency
Definition
Hyponatremia- muscle cramps/spasms, nausea and vomiting, headaches, seizures and coma can occur.
Term
Chloride Function
Definition
Helps maintain electrolyte balance; major part of hydrochloric acid (HCl).
Term
Chloride RDA
Definition
2300 mg/day for adults
Term
Chloride Toxicity
Definition
Acidosis, muscle spasms and cramps.
Term
Chloride Deficiency
Definition
Alkalosis, dehydration, loss of appetite, lethargy, muscle weakness.
Term
Potassium Function
Definition
Principal ion of intracellular fluid; used in nerve impulse transmission and muscle contractions.
Term
Potassium RDA
Definition
4700 mg/day for adults
Term
Potassium Toxicity
Definition
Hyperkalemia- tingling in extremities, muscular weakness, temporary paralysis, and arrythmia (abnormal heart rhythm) which can lead to cardiac arrest.
Term
Potassium Deficiency
Definition
Hypokalemia- fatigue, muscular weakness, muscle cramps, kidney stones, glucose intolerance, irregular heartbeat.
Term
Calcium Function
Definition
Most abundant mineral in body. Bone formation; muscle contraction; neurotransmitter release; hormone release.
Term
Calcium RDA
Definition
1000 mg/day for adults
Term
Calcium Toxicity
Definition
Hypercalcemia- excessive thirst and urination, confusion, lethargy, muscle weakness, nausea and vomiting.
Term
Calcium Deficiency
Definition
Hypocalcemia- osteomalacia leading to osteoporosis, numbness in hands and feet, muscle spasms, memory loss and hallucinations
Term
Phosphorus Function
Definition
Works with calcium to form the bones and teeth; part of cell membrane; part of DNA and RNA; assists in energy metabolism; part of buffer system.
Term
Phosphorus RDA
Definition
700 mg/day for adults
Term
Phosphorus Toxicity
Definition
Can cause calcium uptake to be reduced, blood alkalosis.
Term
Phosphorus Deficiency
Definition
Osteoporosis, anxiety, irratibility, irregular breathing. In children, poor bone and teeth development can occur.
Term
Magnesium Function
Definition
Maintain bone health, energy metabolism, part of protein making machinery, catalyst in ATP production, blood clotting and supports immune system functioning.
Term
Magnesium RDA
Definition
400 mg/day for men
310 mg/day for women
Term
Magnesium Toxicity
Definition
Diarrhea, vomiting, hypotension, difficulty breathing, lethargy.
Term
Magnesium Deficiency
Definition
Loss of appetite, nausea, vomiting, tingling in extremities, muscle cramps, seizures, arrythmia.
Term
Iron Function
Definition
Main part of Hemoglobin and Myoglobin; Cofactor in oxidation-reduction reactions; part of electron carriers.
Term
Iron RDA
Definition
8 mg/day for men
18 mg/day for women
Term
Iron Toxicity
Definition
Diarrhea, vomiting, constipation, nausea.
Term
Iron Deficiency
Definition
Anemia, impaired energy metabolism, behavioral changes (Pica). In adolescents, growth can be impaired as well during puberty.
Term
Zinc Function
Definition
Gene expression; cell membranes; immune function; growth and development; synthesis, storage and release of insulin; blood clotting; thyroid hormone function.
Term
Zinc RDA
Definition
11 mg/day for men
8 mg/day for women
Term
Zinc Toxicity
Definition
Nausea, vomiting, diarrhea, decreased copper metabolism, decreased immune functioning, decrease in levels of HDL.
Term
Zinc Deficiency
Definition
Impaired growth, impaired immune functioning, damage to central nervous system.
Term
Iodine Function
Definition
Needed in the synthesis of thyroid hormone which controls body temp., metabolic rate, reproduction, growth, blood cell production and nerve and muscle function.
Term
Iodine RDA
Definition
150 ug/day for adults
Term
Iodine Toxicity
Definition
Interference of thyroid function, formation of goiter.
Term
Iodine Deficiency
Definition
Decreased thyroid hormone production, brain damage (Cretinism).
Term
Selenium Function
Definition
Part of proteins (substituted for sulfur); antioxidant.
Term
Selenium RDA
Definition
55 ug/day for adults
Term
Selenium Toxicity
Definition
Loss and brittleness of hair, garlic breath odor, nervous system abnormalities.
Term
Selenium Deficiency
Definition
Heart Disease (Keshan Disease).
Term
Copper Function
Definition
Constituent of enzymes; iron metabolism; protects against oxidative damage.
Term
Copper RDA
Definition
900 ug/day for adults
Term
Copper Toxicity
Definition
Liver Damage. Wilson's Disease is genetic disorder where copper builds up in the body.
Term
Copper Deficiency
Definition
Anemia that cannot be fixed with iron supplementation, low white blood cell count.
Term
Manganese Function
Definition
Cofactor of enzymes that facilitate metabolism; bone formation; Conversion of pyruvate to a TCA cycle compound.
Term
Manganese RDA
Definition
2.3 mg/day for men
1.8 mg/day for women
Term
Manganese Toxicity
Definition
Neurological Dysfunction
Term
Manganese Deficiency
Definition
Impaired growth, impaired glucose tolerance, impaired reproductive functioning, skeletal abnormalities.
Term
Fluoride Function
Definition
Found in bones and teeth and prevents dental decay.
Term
Fluoride RDA
Definition
4 mg/day for men
3 mg/day for women
Term
Fluoride Toxicity
Definition
Nausea, vomiting, diarrhea, excessive salivating and tearing, sweating, generalized weakness.
Term
Fluoride Deficiency
Definition
Dental decay.
Term
Chromium Function
Definition
Participates in carbohydrate and lipid metabolism; Maintain glucose homeostasis.
Term
Chromium RDA
Definition
35 ug/day for men
25 ug/day for women
Term
Chromium Toxicity
Definition
None
Term
Chromium Deficiency
Definition
Diabetes-like symptoms including weight loss, neuropathy, and impaired glucose tolerance.
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