Term
small dsDNA, circular, non-enveloped
causes: warts of mucosa or squamous epithelia |
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Definition
Papovaviruses
HPV
Polyomaviruses |
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Term
| Name the serotypes of HPV that cause cervical cancer and are part of the Gardasil vaccine |
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Definition
16, 18
note serotypes 16, 18, 31,33 cause dysplasia/cancer
vaccine covers 6,11 (both cause warts) + 16,18 |
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Term
| Describe the mechanism by which HPV causes cancer |
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Definition
| E6 and E7 viral proteins bind p53 and Rb while E2 represses E6/7; when E2 activity is interrupted by the virus p53 and Rb are consitutively active --> dysplasia --> in situ carcinoma |
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Term
small dsDNA, non-enveloped
causes: acute respiratory disease, pharyngitis, conjunctivitis, hemorrhagic cystitis, acute gastroetneritis in infants
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Definition
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Term
small ssDNA, non-eveloped
causes: erythema infectiosum "slap cheek", aplastic crises in anemic patients, polyarthritis, hydrops fetalis |
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Definition
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Term
Causes orofacial lesions, remains latent in sensory nerve ganglia
Transmission: skin to skin contact
causes syncitia formation
Tzanck smear |
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Definition
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Term
large, linear dsDNA, enveloped
transmission: sexual or during birth
infects and destroys epithelial cells "below the belt"
Tzanck smear |
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Definition
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Term
large, linear dsDNA, enveloped
transmission: skin to skin or airborne
causes: rash in children, dermatomal rash in adults |
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Definition
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Term
large, dsDNA, enveloped
transmission: bodily secretions
causes: perinatal infection during birth, mononucleosis, retinitis, transplantation infections, pneumonia in AIDS patients
"Owl's eye inclusion"
heterophile antibody negatvie |
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Definition
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Term
Large dsDNA, enveloped
causes Roseola and Pityriasis rosea
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Definition
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Term
large, dsDNA, enveloped
causes Karposi's Sarcoma in AIDS patients
transmission: sexual |
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Definition
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Term
large dsDNA, enveloped
infectious heterophile + mononucleosis
Burkitt's lymphoma, nasopharyngeal carcinoma
potential for splenic rupture |
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Definition
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Term
large dsDNA, enveloped
can cause childhood skin rash
potential bioterror agent
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Definition
Poxviruses
molluscum contagiosum- umbilicated pox-like rash
variola (smallpox)- eradicated
vaccina (vaccine strain of smallpox) |
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Term
small partially dsDNA circle, enveloped
transmission: sexual, parenteral, perinatal
often leads to hepatocellular carcinoma |
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Definition
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Term
small, ssRNA +, non-enveloped
transmission: fecal-oral
can cause paralysis, meningitis, encephalitis |
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Definition
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Term
small, ssRNA+, non-enveloped
causes Herpangia; hand, foot, and mouth disease, meningitis
transmission: respiratory |
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Definition
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Term
small ssRNA +, non-enveloped
transmission: respiratory
causes: pleurodynia, myocaridal and pericardial infections |
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Definition
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Term
small ssRNA, non-enveloped
most common cause of the common cold
transmission: respiratory |
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Definition
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Term
small, ssRNA+, non-enveloped
only has 1 serotype
abrupt fever, nausea, anorexia, abdominal pain, icterus
transmission: fecal-oral, contaminated food |
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Definition
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Term
small ssRNA+, non-enveloped
problem in developing countries
10-20% mortality in pregnant women
causes acute hepatitis |
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Definition
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Term
small ssRNA+, non-enveloped
causes gastroenteritis
transmission: fecal-oral/contaminated food
onset within 24-48 hours, self-resolves |
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Definition
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Term
small dsRNA, non-enveloped, double capsid
causes gastroenteritis in infants
causes: fecal-oral, contaminated food
48 hours incubation period |
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Definition
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Term
small, ssRNA+, enveloped
transmission: blood, semen, drug needles
causes: chronic hepatitis, liver failure, cirrhosis |
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Definition
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Term
small ssRNA+, zoonotic, arbovirus
causes encephalitis, arthrogenic disease, hemmorhagic fever, hepatitis |
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Definition
Flaviviruses
-dengue virus
-yellow fever virus
-west nile virus |
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Term
smal ssRNA+, enveloped
transmission: respiratory droplets
causes: rash, if congenital causes developmental problems in the fetus |
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Definition
Rubella
aka German Measles |
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Term
small ssRNA +, enveloped
second most common cause of the common cold
transmission: person to person
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Definition
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Term
small ssRNA +, enveloped
transmission: civet cats to human
causes: severe upper respiratory tract infection, high fever, dyspnea, death |
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Definition
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Term
+ strand RNA virus
requires Hep B co-infection |
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Definition
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Term
small, ssRNA
contains reverse transcriptase
transmission: bodily fluids
infects CD4+ T cells --> immune dysregulation |
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Definition
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Term
small ssRNA
packages revrse transcriptase
can cause Adult T-cell Leukemia or Hairy Cell Leukemia after a long latency period |
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Definition
HTLV-1 (adult T-cell)
HTLV-2 (Hairy cell) |
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Term
smal ssRNA (neg strand)
packages an RNA polymerase
causes: "flu", can cause bronchiolitis, otitis media, and croup in children |
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Definition
orthomyxovirus
Influenza A (human and animal)
Influenza B (human only) |
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Term
small ssRNA (neg strand), enveloped
causes croup (bark-like cough, stridor, subglottal swelling)
transmission: human to human |
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Definition
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Term
small ssRNA (neg strand), enveloped
causes parotitis, orchitis |
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Definition
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Term
small ssRNA (neg strand), enveloped
causes cough, coryza, conjuncitvitis
Koplik spots on bucchal mucosa |
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Definition
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Term
small ssRNA (neg strand), enveloped
causes: bronchiolitis and pneumonia in children
most common cause of lower respiratory tract infection in kids |
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Definition
| respiratory syncytial virus (RSV) |
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Term
small ssRNA (neg strand), enveloped
transmission: bite of an animal
causes: hydrophobia, CNS infeciton, death |
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Definition
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Term
small, ssRNA (neg strand), enveloped
causes: encephalitis, hemorrhagic fever
transmission: mosquito
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Definition
Bunya viruses:
California encephalitis virus
LaCrosse virus
Crimean-Congo virus |
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Term
small ssRNA (neg strand), enveloped
causes: sudden noncardiogenic pulmonary edema, renal failure, death
transmission: inhalation of mouse urine/feces |
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Definition
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Term
small ssRNA, enveloped
causes: severe hemorrhagic fever, shock, death
transmission: airborne, blood |
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Definition
Filoviruses:
Marburg
Ebola
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Term
| Name the early viral proteins expressed by HSV-1 |
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Definition
| DNA polymerase and thymidine kinase which activate viral DNA synthesis |
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Term
When HSV goes into the latent state, no viral proteins are made
name the only thing that is made |
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Definition
| RNA intron called the latency-associated transcript (LAT) |
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Term
| This beta-herpesviradae causes microcephaly and can be latent in lymphocytes, epithelia |
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Definition
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Term
| Varicella pneumonia occurs more often in _____ |
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Definition
adults
because adults have a more robust immune sys |
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Term
| Name the type of cell EBV infects and the cell responsible for the mononucleosis symptoms |
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Definition
| EBV infects B cells, but it is the T-cell response to the infected B-cells that causes symptoms of mono |
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Term
| Name the lymphoproliferative dirosders with which EBV is associated |
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Definition
Burkitt's lymphoma
nasopharyngeal carcinoma
NOn-hodgkin's lymphoma in HIV patients
hodgkin's lymphoma (50%) |
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Term
| Name the viral antigens made by EBV during latency |
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Definition
EBNAs- Epstein-barr nuclear antigens
latent membrane protein (LMP) |
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Term
| Besides CD4, there are two other co-receptors used for HIV entry into T-cells, name them |
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Definition
CCR5 or CXCR4
both are chemokine receptors that belong to the G-protein coupled receptor family |
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Term
| Causes encephalitis primarily in the temporal lobe |
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Definition
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Term
| Enveloped virus with two identical strands of positive (+) sense RNA |
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Definition
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