What are the receptors for:

1. Influenza
2. EBV
3. Rhinovirus
4. Adenovirus
5. Rabies

1. Influenza: sialic acid
2. EBV: CD3 complement receptor on B cells
3. Rhinovirus: ICAM-1 on mucosal cells
4. Adenovirus: CD55 (DAF) and CAR (coxsackie adenovirus receptor)
5. Rabies: acetylcholine receptor on neurons

TNF-α

TNF-β

IFN-γ

IL-12

1. RIG-I detect dsRNA in the cytoplasm
2. TLR's detect viral RNA at the cell surface or within the endosome

IFN upregulates:

1. Mx protein: inhibits viral assembly
2. PKR (protein kinase R): inhibits viral protein translation
3. OAS (oligoadenylate synthase): synthesis poly-A molecule that activates RNase L
4. RNase L: cleaves viral RNA

1. Measles
2. Mumps
3. Rubella
4. Polio

For human parvovirus, give the:

1. Size
2. Enveloped or non-enveloped?
3. Genome, and replicates where?

1. 45 nm
2. Non-enveloped
3. Circular dsDNA, so replicates in the nucleus

For human papilloma virus, give the:

1. Size
2. Enveloped or non-enveloped?
3. Genome, and where does it replicate?

1. 50-55 nm
2. Non-enveloped
3. Circular dsDNA, replicates in the nucleus

Opportunistic infections:

1. SV40 in monkeys
2. BK: renal disease
3. JC: PML, B cell and monocyte infection

1. HPV 6 and 11: genital warts
2. HPV 16 and 18: cervical hyperplasia

1. How is human parvovirus transmitted?
2. How is human papilloma virus transmitted?

1. Inhalation
2. Contact with surfaces

Late T antigen:

1. Initiates transcription of viral DNA
2. Binds to p53 and P105RB to induce S phase in the host cell

1. E1 and E2 initiate transcription of viral DNA
2. E6 and E7 bind to P53 and P105RB to induce S phase in the host cell

Parvovirus: plasmid

Papilloma virus: integrated

For herpes virus:

1. Size?
2. Enveloped or non-enveloped?
3. Genome and replication site?
4. Histone-bound?

1. 75-150 nm
2. Enveloped
3. dsDNA
4. Only latent DNA bound by histone

1. Immediate Early: alpha proteins that act as transcription factors for beta proteins
2. Early: beta proteins that are both enzymes (including DNA polymerase) and transciption factors for gamma proteins
3. Late: gamma proteins that are structural proteins

1. Genital and non-genital warts
2. Encephalitis (HSV-1)
3. Meningitis (HSV-2)
4. Gingivostomatitis
5. Herpetic keratitis
6. Herpetic Whitlow
7. Neonatal herpes

1. Kaposi's sarcoma
2. Castleman's disease (non-malignant B cell proliferative disorder)
3. Body-cavity based effusion lymphoma

1. Heterophile Ab (-) infectious mono
2. Transplacental disease

1. Heterophile Ab (+) infectious mononucleosis
2. Burkitt's lymphoma
3. Nasopharyngeal carcinoma