Term
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Definition
-3 open reading frames (ORFs)
-ORF1 - polpeptide -->protease, helicase, RNA polymerase
-ORF2 - capsid proteins
-ORF3 - protein which helps w. virus assembly |
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Term
| Nidovirales (coronaviridae and arteroviridae) replication |
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Definition
Nested transcripts
-each w. a poly-A tail, varying length middle, leader sequence
-protein nearest 5'end leader is translated - economical |
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Term
| Rotavirus (orbivirus similar) replication |
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Definition
-capsid has 3 layers
-genome remains in core particle, which has RNA polymerase and capping enzymes - dsRNA is potent IFN inducer and is kept hidden from host |
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Term
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Definition
-polycistronic single open reading frame
-does not usually cut off host cell synthesis
-exocytosis without cell lysis |
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Term
| Bovine Viral Diarrhoea Virus replication |
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Definition
-polycistronic single open reading frame
-does not usually cut off host cell synthesis
-exocytosis without cell lysis
-virus non-structural protein protease NSP2/3 blocks IFN production
(mutations in this result in cytopathic form of disease) |
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