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Virology
(MSU - MMG 413) Virus descriptions, specialty functions, etc. Specific for Fluck/Thiem Final Exam.
83
Microbiology
Undergraduate 4
05/02/2011

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Cards

Term
Polio 1, 2, 3
Human Rhinovirus
Hepatitis A/E
Definition
ssRNA (+)
non-segmented
no envelope
Term
Rubella
Hepatitis C
Definition
ssRNA (+)
enveloped
1 sub-genomic mRNA
Term
Coronaviruses
SARS
Definition
ssRNA (+)
non-segmented
enveloped
Term
Mumps
Measles
Rabies
Ebola (Zaire & Sudan)
Definition
ssRNA (-)
non-segmented
enveloped
Term
Influenza A, B, C
Definition
ssRNA (-)
segmented
enveloped
Term
Reovirus 1, 2, 3
Rotavirus A, B
Colorado Tick Fever
Definition
dsRNA
(+)
segmented
no envelope
Term
HTLV
HIV 1, 2
Definition
ssRNA (+)
retroid DNA step in replication
Term
Hepatitis B (HBV)
Definition
ds/ssDNA
enveloped
retroid DNA step in replication
Term
Parvoviridae
(RA-1)
Definition
ssDNA
no envelope
Term
Polyoma
Papilloma
Definition
dsDNA
no envelope
Term
Herpesviridae
(HSV, HHV, Herpes B)
Poxviridae
(smallpox)
Definition
dsDNA
enveloped
Term
Baltimore Classifications
(1 - 7)
Definition
1) dsDNA
2) ssDNA
3) dsRNA
4) ssRNA (+)
5) ssRNA (-)
6) ssRNA (+) w/DNA intermediate
7) gapped circular dsDNA
Term
Class I - dsDNA
Definition
Pox
Papilloma
Term
Class II - ssDNA
Definition
Parvo
Term
Class III - dsRNA
Definition
Reo/Rota
Term
Class IV - ssRNA (+)
Definition
Polio
Term
Class V - ssRNA (-)
Definition
Rabies
Influenza
Term
Class VI - ssRNA (+) w/DNA intermediate
Definition
HIV
Term
Class VII - gapped circular dsDNA
Definition
HBV
Term
What 2 viruses have segmented genomes?
Definition
Influenza
Reo/Rota
Term
What 3 viruses have circular genomes?
Definition
SV40 (polyoma)
Papilloma
HPB (not covalently closed)
Term
Genome - RABIES
Definition
ssRNA (-)
linear
NO direct/inverted repeats
NOT covalently linked to proteins
Term
Virion - RABIES
Definition
enveloped
rod shaped/filamentous
genome coated w/VIRAL protein
viral RNA polymerase
Term
Attachement/Entry - RABIES
Definition
genome in cytoplasm
entry by fusion
Term
mRNA synthesis - RABIES
Definition
cytoplasm
viral RNA-dep RNA-pol
NO genome conversion
Term
Capping - RABIES
Definition
viral polymerase and host enzyme
poly(A) tail via polymerase slippage
Term
Rep. intermediates NOT mRNAs.
Definition
Rabies
Influenza
Term
What VSV/Rabies virus uses protease for maturation?
Definition
EBOLA uses Furin, a CELL protease.
Term
Genome - INFLUNZA
Definition
ssRNA(-)
linear
segmented
NO direct terminal repeats
NOT covalently linked to protein
Term
Virion - INFLUNZA
Definition
enveloped
genome coated with viral protein
viral RNA polymerase
Term
Attachment/Entry - INFLUENZA
Definition
binds carbohydrate
uncoated via fusion (late endosomes)
genome migration to nucleus
Term
mRNA synthesis - INFLUENZA
Definition
Nuclear process
HOST RNApolII
Term
capping - INFLUENZA
Definition
VIRAL endonuclease cleaves host enzyme after capping.
Host mRNAs provide caps.
Cleaved oligonucleotide used as primer.
Term
maturation - INFLUENZA
Definition
HOST protease used to cleave after assembly at plasma membrane.
Term
Genome - POLIO
Definition
ssRNA (+)
linear
non-segmented
covalently linked to protein
Term
Virion - POLIO
Definition
naked virus - icosahedral shape
uses host polymerase
Term
attachment/entry - POLIO
Definition
binds cell surface protein
genome remains in cytoplasm
Term
Which is the only virus to make a single mRNA?
Definition
Polio (picornavirus)
Term
What virus encodes poly(A) tail in genome?
Definition
Polio (picornavirus)
Term
Which 3 viruses initiate genome replication via protein priming?
Definition
Polio (picornavirus)
Adenovirus
HBV
Term
Which 3 viruses produce equal amounts of viral capsids and polymerase?
Definition
Polio (picornavirus)
Togavirus
Retrovirus
Term
What 2 viruses assemble capsids in the cytoplasm?
(using a viral protease)
Definition
Polio (picornavirus)
Togavirus
Term
Genome - TOGAVIRUS
Definition
ssRNA (+)
linear
Term
Virion - TOGAVIRUS
Definition
enveloped
icosahedral
Term
TOGAVIRUS after attachment...
Definition
mRNA synthesized in cytoplasm via VIRAL polymerase.
Encodes protease that makes individual proteins.
Produces 2 mRNAs.
Term
Which 2 viruses code for a DNA polymerase in the virion?
Definition
Retrovirus
Hepatitis B
Term
Genome - CORONA/SARS
Definition
ssRNA (+)
linear
Term
Virion - CORONA/SARS
Definition
enveloped
spherical
Term
Uncoating - CORONA/SARS
Definition
uncoated via fusion
genome remains in cytoplasm
Term
Capping - CORONA/SARS
Definition
Capping/mRNA synthesis via viral polymerase in cytoplasm.
Viral protease makes polyproteins.
Term
Genome - RETROVIRUS
Definition
diploid
ssRNA (+)
linear
direct terminal repeats
Term
Virion - RETROVIRUS
Definition
enveloped
icosahedral
genome coated w/viral protein
DNA polymerase
Term
Which virus converts the genome in the cytoplasm?
Definition
Retroviruses
Term
Attachment/entry - RETROVIRUS
Definition
Binds cell surface protein.
Fusion to plasma membrane.
Genome migrates to nucleus.
Term
Which 2 viruses encode a reverse transcriptase?
Definition
Retrovirus
Hepatitis B
Term
Genome - HBV
Definition
partial dsDNA
covalently linked to protein
circular genome
3 direct repeats - 2 near 3' end
Term
Virion - HBV
Definition
enveloped
icosahedral
DNA polymerase encoded
Term
T/F - HBV genome migrates to the nucleus.
Definition
TRUE
Term
Which 2 viruses encode a DNA-dep DNA pol, RNA-dep DNA pol, and a reverse transcriptase?
Definition
Retroviruses
HBV
Term
SV40
Definition
Polyoma
Term
Genome - SV40
Definition
dsDNA
circular
Term
Virion - SV40
Definition
icosahedral
not enveloped
genome coated w/CELL protein
Term
T/F - SV40 genome migrates to the nucleus after entry.
Definition
TRUE
Term
SV40 after uncoating..
Definition
mRNA synthesis in nucleus by polII
capsids assemble in nucleus
bidirectional DNA synthesis
Term
Which 3 viruses produce mRNAs from both DNA strands?
Definition
SV40
Adeno
Herpes
Term
Which 2 viruses replicate their genome via strand displacement?
Definition
Adeno
POX
Term
Genome - Papilloma
Definition
dsDNA
circular
Term
Virion - Papilloma
Definition
icosahedral
genome coated w/CELL protein
genome migrates to nucleus
Term
What 3 viruses use host polymerases?
Definition
SV40
Papilloma
Parvo
Term
Genome - ADENO
Definition
dsDNA
linear
unsegmented
covalently linked to protein
inverted terminal repeats
Term
Virion - ADENO
Definition
icosahedral
genome migrates to nucleus
Term
Genome - REO/ROTA
Definition
dsDNA
linear
Term
Virion - REO/ROTA
Definition
icosahedral
RNA polymerase in virion
genome remains in cytoplasm
Term
T/F - mRNA synthesis and capping is done by a viral polymerase in REO/ROTA.
Definition
TRUE
Term
This virus assembles in the endoplasmic reticulum.
Definition
Herpes
Term
What is the only virus to produce one mRNA?
Definition
Polio (picornavirus)
Term
Genome - HERPES & POX
Definition
dsDNA
linear
Term
This virus uses fusion to uncoat, then sends the genome to the nucleus.
Definition
Herpes
Term
This is the only virus to produce 2 mRNAs.
Definition
Togavirus
Term
This is the only virus to inhibit host translation.
Definition
Polio (picornavirus)
Term
Only virus to use cell RNA to initiate genome replication.
Definition
Retrovirus
Term
Encodes poly(A) tail in genome.
Definition
Polio (picornavirus)
Term
Genome conversion in nucleus only occurs in which 2 viruses?
Definition
Hepatitis B
Parvo
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