Term
Mumps
Family?
Age of infection? |
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Definition
Paramyxoviridae
5-15 years |
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Term
Mumps
Structure
Replication |
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Definition
SS (-) RNA Virus
Enveloped
Has 2 spikes: 1 with H and N activity, 1 with F activity
Replicates in cytoplasm like normal RNA (-) virus |
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Term
Mumps
Describe the clinical disease. |
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Definition
| Enter respiratory tract where it replicates and spreads to lymph nodes. 12-29 days after exposure, one has parotiditis and symptoms last 7-10 days. |
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Term
Mumps
What are some of the common complications? |
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Definition
1. Meningitis
2. Encephalitis
3. Pancreatitis
4. Orchitis (10-20% of men)
5. Oophoritis
6. Myocarditis |
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Term
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Definition
| Genus Morbillivirus of paramyxoviridae family |
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Term
Measles
Describe the structure and replication |
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Definition
1. SS (-) RNA virus
2. Nucleoprotein complex
3. Enveloped
4. Has 2 spikes: One has H and N activity and the other is called F (fusion) protein.
5. Replicates in cytoplasm like a normal (-) RNA virus.
6. No neuramindase activity in envelope
Very similar to Mumps, b/c they are both paramyxoviridae |
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Term
Measles
Describe the clinical disease |
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Definition
1. Enters respiratory tract and replicates
2. Spreads to local lymph nodes
3. Transported to all body organs, symptoms occur 7-18 days post exposure
4. Koplik spot first appear in mouth as small bluish yellow spots 1-2 days before rash
5. Rash first appears on head, then trunk and extremities |
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Term
Measles
What are some of the symptoms? |
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Definition
| 1. High fever, delirium, cough, photophobia, conjunctivitis. |
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Term
Measles
What are some of the complications? |
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Definition
1. Encephalitis
2. Bacterial superinfection: otitis media, mastoiditis, pneumonia, sinusitis.
3. Death: extensive progressive viral infection |
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Term
Rubella
What is the family?
Describe the structure and replication. |
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Definition
Togaviridae
1. Icosahedral, enveloped virus
2. SS (+) RNA
3. Enters by receptor mediated endocytosis
4. Produces its own RNA polymerase
5. Virus assembly takes place at golgi or plasma membrane |
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Term
Rubella
Describe the clinical course of the disease. |
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Definition
1. Virus enters through inhalation
2. Multiplies in upper respiratory tract
3. Spreads to regional lymph nodes
4. Symptoms appear 14-21 days post infection.
5. Mild fever with rash.
6. Rash first appears on head, neck, and trunk
7. Symptoms persist 1-3 days
8. Contagious from 7 days before to 7 days after the onset of rash
9. Immunity life-long
10. Mainly seen in the winter-spring season.
11. Can be contracted through maternal pacental. |
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Term
Rubella
What are some of the clinical manifestations of congenital rubella? |
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Definition
1. Cardiac defects
2. Ocular defects
3. Hearing loss
4. Liver/spleen enlargement
5. Thrombocytopenia
6. Failure to thrive
7. Low birth weight
8. Mental retardation
9. Mortality during first year of life |
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Term
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Definition
| Hemagglutination inhibition test |
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Term
Erythema Infectiosum
Family? |
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Definition
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Term
Erythema Infectiosum
Structure and replication? |
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Definition
1. Small, iscoahedral, single-stranded DNA virus
2. Replicates in nucleus of dividing cells
3. Virus assembly takes place in the nucleus
4. Virus released by cell disruption |
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Term
Erythema Infectiosum
Describe the clinical disease. |
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Definition
1. Mild fever, headache, rash
2. Slapped face rash persists 1-2 weeks, may recur |
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Term
Roseola infantum
What is the agent of disease |
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Definition
| i. Agent human herpes virus type 6, adenovirus, coxsackievirus, echovirus |
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