Term
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Definition
basic
self replicating
can infect any type of organism
classified by nucleic content and how they replicate their genomes
DNA <-> RNA -> Protein |
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Term
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Definition
RNA replication in cytoplasm
host cell coopted to prioritise virus production
host cell frozen so it can't apoptose |
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Term
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Definition
| genome transcribed in nucleus |
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Term
| viral detection in clinical setting |
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Definition
ELISA/EIA
usually combined tests
many tests are indirect - look for antibodies against the virus
means you have to question whether positive results are from virus or natural/acquired immunity
IgM,IgG,tests
positive results confirmed by PCR |
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Term
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Definition
immunological
-antigen, antibody, secondary antibody, florophore
ELISA
Directly via visualisation
- electron microscopy
-plaque assay
-DNA sequencing
- mass spec of nucleic acids and proteins |
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Term
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Definition
take over of proteins/metabolites
- change cell shape, organelle arrangment
induce pro inflammatory state
transcriptomics - map host RNA levels in cells and individual
Proteomics - map host proteins in cell and individual
some proteins are found to be essential to virus, these can be targeted |
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Term
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Definition
vaccination
anti-viral drugs |
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Term
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Definition
prime adaptive immune system
use antigenic properties of one or more viral proteins
can be either whole inactivated, weak or chimera |
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Term
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Definition
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Term
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Definition
| whole viruses that can't replicate anymore - chemical or radiation inactivation |
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Term
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Definition
usually designed to bind or block activity
use knowledge of structure and function of virus
inevitable virus mutation is major disadvantage |
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Term
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Definition
can be genetically and mechanically altered for multiple purposes
control of pest insects
bacteriophage therapy of antibiotic resistant infections
oncolytic viruses - target and destroy cancer cells
gene therapy - induce corrective or silencing genes |
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