Term
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Definition
Binds capsid/ blocks entry
Blocks many picornaviruses |
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Term
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Definition
| blocks a conformational change in HIV envelope gp41 that is required for fusion and viral entry |
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Term
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Definition
| blocks attachment of HIV by binding to CCR5 |
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Term
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Definition
| blocks ion channels that allow H+ to enter virions within endosomes and inhibits uncoating of influenza virion |
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Term
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Definition
Drugs specific for viral polymerase
Activated by viral kinases in infected cells |
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Term
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Definition
Nucleoside analogue
preferentially phosphorylated by HERPES thymidine kinase
incorporated into DNA by viral DNA pol |
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Term
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Definition
| Cytomegalovirus serine/threonine protein kinase phosphorylates Ganciclovir |
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Term
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Definition
phosphorylated by cell Thymidylate kinase and nucleoside diphosphate kinase
HIV-1 RT incorporates into DNA- premature chain termination |
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Term
| Non nucleoside inhibitors |
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Definition
selectively target viral replication enzymes
bind near active site of the enzyme |
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Term
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Definition
Non nucleoside inhibitor
bind to a spot near the active site and slow the rate of HIV DNA polymerization |
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Term
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Definition
non nucleoside inhibitor
inhibits HIV viral integrase |
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Term
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Definition
| Interfere with viral assembly and maturation |
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Term
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Definition
protease inhibitor of HIV-1
Peptidomimetic drug that mimics peptide |
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Term
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Definition
neuraminidase inhibitor
cleave sialic acid, releasing virus |
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