Term
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Definition
dsDNA
approx 40proteins (10x moe than parvovirus) |
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Term
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Definition
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Term
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Definition
| infectious tracheo-bronchitis (kennel cough) |
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Term
| adenovirus infection in deer = |
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Definition
| haemorrhagic vasculitis and pulm oedema |
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Term
| adenovirus infection in foals = |
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Definition
| SCID (severe combined immundoeficiency) |
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Term
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Definition
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Term
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Definition
| icosahedral with spike proteuns at each vertex/edge - look like drumsticks sticking out of virus |
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Term
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Definition
| adhesion proteins to attach to host cell |
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Term
| early/intermediate genes = |
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Definition
| virus isnt replicating, not killing cell, just intefereing with cell |
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Term
| early/intermediate genes function = |
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Definition
1. cell progression (DNA synth)
2. interfere with action of host p53 enzyme (tumour supressor protein)
3. protect cell from TNF (inhibit TNF)
4. decr MHC I expression = immune evasion |
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Term
| some adenoviruses can form ______ infections with reactivation following _______ _________ |
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Definition
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Term
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Definition
-involved in shutting down host cell protein synth = kill host cell
-structural viral proteins synthesised in XS |
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Term
| empty or complete virus capsids cause... |
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Definition
| ....large crystalline arrays in host cell nucleus |
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Term
| adenovirus leaves cell via |
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Definition
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Term
| canine adenovirus 1 (CAV1) infects |
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Definition
dogs
wild canines
skunks
bears |
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Term
| CAV1 replication occurs in... |
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Definition
| ...host cell nucleus - can see inclusion bodies in ohst cell nucleus |
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Term
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Definition
| ...kidney and liver cells |
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Term
| symptoms of CAV1 infection depend on... |
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Definition
...virus strain
cell type infected
extent of infection |
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Term
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Definition
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Term
| peracute (sudden onset of dz) CAV1 infection = |
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Definition
| generalised infection of young niave animals, massive destruction of hepatocytes, huge inflam response = rapid death |
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Term
| subacute (between acute and chronic) CAV1 infection |
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Definition
fever
conjunctivitis
nasal dishcarge
abdo pain (can palpate large painful liver)
in more severe cases :
-petichiae of mucosa
-bleeding
-DIC
-leucopaenia (decr WBCs)
-V+ and bloody D+
-jaundice
protracted/long recovery time with slow weight gain |
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Term
| why do you get bleeding disorders with CAV1 infection? |
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Definition
| damage liver = decr clotting factors (made in liver) = haemorrhage = use up clotting factors = bleeding problems such as petichiae and DIC |
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Term
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Definition
-due to Ab/virus complexes due to XS production of late viral proteins
-commonly manifests as corneal oedema (blue eye)
-may cause glomerular nephritis = loss of kidney function = proteinuria |
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Term
| CAV2 infection confined to... |
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Definition
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Term
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Definition
| ...kennel cough syndrome (like canine parainfluenza virus 2) |
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Term
| clincial signs of CAV2 infection = |
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Definition
conjuncticitis
discharge from nose
could be CAV2, CDV or acute hepatitis (CAV1) therefore dx is v imp to see if serious dz or not |
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Term
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Definition
histopathology
serology
haemagglutination inhibition test
PCR |
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Term
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Definition
1. live attenuated type 1
2. live attenuated type 2 |
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Term
| live attenuated type 1 vacc = |
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Definition
originally used
can cause corneal oedema and maybe glomerula nephritis, as qu aggressive vacc |
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Term
| live attenuated type 2 vacc = |
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Definition
universally replaced live attenuated type 1.
-sufficiently close to CAV 1 to provide cross protection and also protects against CAV2 kennel cough :) = 2in1vacc |
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Term
| extensive use of the live attenuated type 2 vacc has resulted in..... |
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Definition
| the virtual dissappearance of severe forms of dz |
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