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Viral Infections
Anti-viral Drugs Chapter 36
48
Medical
Post-Graduate
03/07/2011

Additional Medical Flashcards

 


 

Cards

Term
Enfuvirtide (T20)
Definition

Blocks g41

use for HIV

can give GB syndrome and 6th nerve palsy

Term
Amantadine
Definition

Influenza A and Parkinsonism

Stops  uncoating by blocking M2

Can cause - mental disorders

Term
Rimantadine
Definition

Influenza A

Stops  uncoating by blocking M2

Can cause - mental disorders

Term
Acyclovir
Definition

HSV and VZV

Anti-herpes Nucloeside analogue

dG

renal failure and (enceph in 1%)

Term
Famciclovir
Definition

HSV and VSV

Antiherpes nucleoside (dG)

erythema multiforme

 

Term
Penciclovir
Definition

HSV and VSV

Antiherpes nucleoside (dG)

erythema multiforme

Term
Ganciclovir
Definition

CMV

Antiherpes nucleoside

neutropenia, thrombocytopenia, anemia (toxic to Bone Marrow)

 

 

Term
Cidofovir
Definition

CMV retinitis

AntiHerp NucleoTide Analogue

Doesn't need viral thymidine kinase, is phosphorylated by cellular enzyme

 

 

Term

 

Phosphorylated by viral thymidine kinase EXCEPT for Cidofovir

Definition
AntiHerpes Nucleosides/tides phosphorylation
Term
Cidofovir
Definition
Nephrotoxicity, neutropenia, metaboic acidosis, decreased intraocular pressure
Term
Interferon B
Definition
MS
Term
Inter alpha
Definition
HCV,HBV, Kaposi's sarcoma, chronic myeloid Leukemia, hairy cell leukemia, malignant melanoma, renal cell carcinoma
Term
imiquimod
Definition

HPV, basal cell carcinoma, Actinic keratosis

Use TLR's

Term
Fomivirsen
Definition

CMV retinitis

Oligonucleotide

Term
Ribavirin
Definition

RSV

Hep C

Dont give to pregnant women

Error catastrophe

Term
Zanamivir
Definition

Infl A and B

Neuroamidase

inhaler

Term
Oseltamivir
Definition

Infl A and B (theraflu) Proph and Tx

Neuraminidase blocker

 

Term
----- navir
Definition
Protease inhibitor
Term
---- navir
Definition
inhibits viral maturation
Term
----navir
Definition
HIV
Term
----navir
Definition

Dyslipidemia (increase cholesterol, increase Triglycerides), lipodystrophy, hyperglycemia

 

Buffalo hump

Term
Nonnucleoside Reverse Transcriptase inhibitors (NNRTI's)
Definition
Efavirenz
Term
Nonnucleoside Reverse Transcriptase inhibitors (NNRTI's)
Definition
Nevirapine
Term
Nonnucleoside Reverse Transcriptase inhibitors (NNRTI's)
Definition
Delaviridine
Term
Rash and psychiatric effects
Definition
Nonnucleoside Reverse Transcriptase inhibitors (NNRTI's) side effects
Term
Efavirenz
Definition
Weird Dreams
Term
Foscarnet
Definition
Nonnucleoside DNA polymerase inhibitor
Term
Foscarnet
Definition
mimicks pyrophosphate
Term
Foscarnet
Definition
HSV and CMV but not a nucleoside analogue
Term
Major side effect of Foscarnet
Definition
Renal Impairment
Term
Lamivudine
Definition
HBV nucleoside analogue
Term
Lamivudine
Definition
the least toxic antiHIV/HBV nucleoside
Term
Tenovir
Definition

anti-HIV nucleoTide

can cause lactic acidosis and hepatotoxicity

Term
Adefovir
Definition

anti-HBV nucleoTIde analogue

can cause lactic acidosis and renal toxicity

Term
Abacavir
Definition

Fatal hypersensitivity

Anti-HIV nucleoside

Term
Didanosine
Definition

Anti-HIV nucleoside analogue

causes pancreatitis

Term
Didanosine (ddI)
Definition
peripheral neuropathy, lactic acidosis, lipodystrophy
Term
Zalcitabine (ddC)
Definition
peripheral neuropathy, lactic acidosis, lipodystrophy
Term
Stavudine (d4T)
Definition
peripheral neuropathy, lactic acidosis, lipodystrophy
Term
NRTI's
Definition
Neutropenia, anemia, pancreatitis, LA, hepatomegaly, optic neuritis, peripheral neuropathy
Term
Neutro, Leuko, and thrombocytopenia
Definition
SE for Ganciclovir
Term
Nevirapine and amprenavir
Definition
assoc with Stevens Johnson
Term
PI's
Definition

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HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism
Term

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Ganciclovir, zidovudine, saquinavir, and interferon
Definition

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Antivirals associated with neutropenia
Term

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AZT (zidovudine)
Definition

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HIV med used to reduce transmission during birth
Term

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Antivirals that are teratogens
Definition

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Antivirals that are teratogens
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