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Vet 210 BRCC
Gastrointestinal Disease
117
Veterinary Medicine
Undergraduate 2
02/21/2010

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Term
6 Types of Oral Disease
Definition
Oral inflammation
Periodontal disease
Lip Fold Dermatitis
Oral Trauma
Oral Neoplasia
Feline Eosinophilic Complex
Term
Gingivitis
Definition
inflammation of the gums
Term
Stomatitis
Definition
Inflammation of oral mucous membranes
Term
Glossitis
Definition
inflammation of the tongue
Term
Periodontal Disease
Definition
Affects all structures involved with tooth attachment, 60-80% of dogs and cats are affected, starts w/ plaque and the bacteria in the plaque gradually damage tooth attachments and alveolar bone leading to tooth loss
Term
Plaque
Definition
white, slippery film composed of bacteria, food, debris, exfoliated cells, and saliva
Term
Dental Calculus
Definition
mineralized plaque
Term
Periodontal Disease Clinical Signs
Definition
Asymptomatic, halitosis, reluctance to chew, pawing at mouth, head shy, oral pain, personality changes, sneezing/nasal discharge, increased salivation, facial swelling, tooth loss, weight loss
Term
Halitosis
Definition
Bad breath
Term
Periodontal disease Treatment
Definition
dental scaling/polishing, subgingival curettage, root planing, extractions, antibiotics
Term
Lip fold dermatitis
Definition
cheilitis, acute or chronic inflammation of the lips, usually secondary to trauma, foreign body, periodontal disease, or stomatitis. Also secondary to licking infected skin or wounds. Pendulous lips allow food and salivation accumulation.
Term
Lip fold dermatitis Clinical Signs
Definition
Scratching or rubbing at lips, foul odor to breath, excess salivation, anorexia, perioral hair discolored, moist, or matted with thick yellow-brown malodorous discharge. Perioral skin hyperemic and ulcerated
Term
Hyperemic
Definition
red d.t. increased blood flow to the area
Term
Lip Fold Dermatitis Treatment
Definition
sedate, clip hair, cleanse daily
Treat PD/stomatitis
Treat primary lesions
May require surgical resection of lips
Term
Things clients should do about Lip Fold Dermatitis
Definition
Keep lips clean and dry
Frequent hair trimming
Good dental hygiene
Use a light dusting of cornstarch to keep area dry
Term
Oral trauma
Definition
Due to many causes, may involve a mandibular symphasis fracture, may be due to linear foreign bodies, fish hooks, bones, sticks, etc
Term
Oral Trauma Clinical Signs
Definition
history, increased salivation, inability to close mouth, reluctant or unable to eat, presence of a FB, pawing at mouth
Term
2 most common malignant oral tumors
Definition
malignant melanomas - dogs w/ heavily pigmented mouths
squamous cell carcinomas
Term
2 most common benign oral tumors
Definition
Papillomas - viral etiology
Epulis/Epulides - occur in gingiva, near incisors (hyperplasia)
Term
Feline Eosinophilic Complex
Definition
AKA Indolent/Rodent ulcers, often on upper lip, idiopathic, lesions are an accumulation of inflammatory cells - mostly eos. Red, well-circumscribed lesion, ulcerated, raised edges, may extend up to the nose
Term
Feline Eosinophilic Complex Treatment
Definition
Corticosteroids (Depo-Medrol), laser, radiation, cryotherapy for unresponsive lesion
Term
Pepsinogin
Definition
Converted to pepsin breaks down protein, stimulates more HCl and gastrin release
Term
Gastrin
Definition
Hormone, stimulates release of mucus and HCl
Term
Mucus and Bicarbonate Ion
Definition
reduce acidity due to HCl and helps protect lining of stomach
Term
5 Stomach Diseases
Definition
Acute gastritis
Immune mediated inflammatory bowel disease
gastric ulcers
Gastric dilation and volvulus
Gastric neoplasia
Term
Acute Gastritis
Definition
Inflammation of the stomach, inflammation and mucosal damage occur in response to gastric mucosal insult
Term
Acute Gastritis Clinical Signs
Definition
Variable appetite/anorexia
vomiting +/- diarrhea
Dehydration
painful abdomen
Increase salivation
Term
Acute Gastritis Treatment
Definition
most cases are self-limiting and do not require treatment, NPO 8-36 hrs, fluids if dehydrated, antiemetics (metoclopramide), antacid (cimetidine), protective (sucralfate), antibiotics. Once animal stops vomiting place on a bland diet. If vomiting continues, recheck.
Term
Inflammatory Bowel Disease (IBD)
Definition
Immune mediated inflammatory bowel disease; chronic gastritis, enteritis, colitis; most common in cats; accumulation of inflammatory cells w/in the GI mucosa. Idiopathic
Term
Inflammatory Bowel Disease (IBD) Clinical Signs
Definition
Chronic vomiting/diarrhea, wt. loss, straining to defecate, melena, hematochezia, palpate thickened bowel loops
Term
Inflammatory Bowel Disease (IBD) Treatment
Definition
Hypoallergenic diets, treat for parasites, immunosupressive doses of prednisone. Non-responsive - azathioprine or cyclophosphamide. Bacterial overgrowth - metronidazole, sulfasalazine. Reduce dose of corticosteroids to lowest effective dose. Therapy required for life.
Term
Side effects of immunosuppressive drugs
Definition
PU/PD
Polyphagia
Weight Gain
Skin and UTI
May shorten life span
Term
Gastric Ulcers
Definition
AKA Gastric erosive or ulcer disease. Caused by NSAIDs, corticosteroids, hepatic and renal insufficiency, uremic toxins, Addison's Disease, FB, Heliobacter spp., stress
Term
Erosions
Definition
Penetrate only into the mucosal layer
Term
Ulcers
Definition
Penetrate past the mucosa into connective tissue. Maybe even into muscularis. May perforate stomach.
Term
Gastric Ulcers Clinical Signs
Definition
Asymptomatic, vomiting is m.c. sign. Pale mucous membranes, anemia, abdominal pain, septicemia (if perforated), wt. loss, anorexia
Term
Gastric Ulcer Treatment
Definition
Fluid therapy, blood transfusion, antiulcer drugs, antibiotic for Heliobacter, perforations - stabilize and do exploratory surgery. Do no use NSAIDs or steroids w/out vet supervision. Limit stress on animal.
Term
4 Antiulcer Drugs
Definition
H2 blockers (cimetidine)
Omeprazole
Protectants (Sucralfate)
Prostaglandins (misoprostol) - prevents ulcers from NSAIDs
Term
Gastric Dilation and Volvulus (GDV)
Definition
Blocks return of blood to the heart, increases stomach pressure causing ischemia and necrosis of gastric wall. Spleen may become congested. Endotoxins from GI tract activate inflammation. Results in hypovolemic and endotoxic shock. It is life threatening and survival is dependent on early recognition and treatment. Disease of large breed, deep chested dogs. Can occur at any age.
Term
Volvulus
Definition
Twisting of the stomach on its long axis, occludes the passage of gastric contents through the esophagus or duodenum.
Term
Dilation
Definition
overdistension of the stomach with ingesta, gas, or fluid
Term
7 GDV Risk Factors
Definition
Age, breed, conformation
Laxity of gastric ligaments
Large volumes of food or water
Delayed gastric emptying
Postprandial exercise
Accumulation of gas - aerophagia
Failure of normal vomiting or eructating reflex
Term
GDV Clinical Signs
Definition
Acute, non-productive retching
Hypersalivation
Abdominal pain/distension
Increased HR and RR
Weakness/collapse
Depression
Nausea
Brick red MM from endotoxins
Arrhythmias - VPCs
Term
GDV Treatment
Definition
Manage/prevent shock
Decompress stomach
Fluid therapy
Stabilize dog and prep for sx
Term
4 Decompression Methods
Definition
Trocar - 16-18 g needle inserted into area of most tympany
Orogastric Tube - may need to sedate
Temporary gastrotomy tube
Gastric lavage
Term
3 GDV surgical interventions
Definition
Gastropexy
Gastric resection
Splenectomy
Term
Gastric Neoplasia
Definition
Occurs frequently in dogs, assoc. w/ FeLV in cats. Adenocarcinoma m.c. in dogs. Lymphosarcoma m.c. in cats - discrete mass or diffuse in mucosa.
Term
Gastric Neoplasia Clinical Signs
Definition
Chronic and progressive vomiting
Weight Loss
Obstruction
Melena
Hematochezia
Term
Microvilli
Definition
Brush border, absorption of nutrients
Term
Crypt Cells
Definition
From the bottom of the villus, produce new cells that replace old villus cells as they slough off of the top
Term
Goblet cells
Definition
produce mucus
Term
Secretin
Definition
Stimulates the pancrease to release bicarbonate and the liver to increase bile production
Term
Cholecystokinin
Definition
Stimulates the pancrease to release digestive enzymes and the liver to empty gall bladder
Term
Gastric Inhibitory Peptide
Definition
Decreased stomach activity
Term
4 Small Intestine Diseases
Definition
Impairment of the absorbtive villous surface
Malabsorbtion
Diarrhea
Small intestinal neoplasia
Term
Acute Diarrhea
Definition
The most common type of diarrhea seen in a small animal clinic
Term
3 Causes of Acute Diarrhea
Definition
Diet change, drug therapy, stress
Term
5 Types of Diarrhea
Definition
Acute
Parasitic
Bacterial
Viral
Dietary intolerance/sensitivity
Term
Signs of Parasitic Diarrhea
Definition
Diarrhea, vomiting, blood in vomit or diarrhea, wt. loss, poor hair coat.
Term
3 Viral Diarrheas
Definition
Canine Parvovirus
Canine Corona Virus
Feline Panleukopenia/Parvovirus
Term
Canine Parvovirus
Definition
Affects intestinal villi and they collapse. Virus is shed in feces, vomit, and saliva. Can be spread by fomites. Persists in the environment for long periods of time. Pt is contagious - avoid other dogs. Clean fecal matter up for several weeks after. Use a 10% Clorox solution to clean area. VACCINATE!
Term
Canine Parvovirus Clinical Signs
Definition
Vomiting
Depression
Fever
Bloody Diarrhea
Anorexia
Lethargy
Dehydration
Term
Canine Parvovirus Diagnosis
Definition
ELISA test
Decreased WBC count
Viral detection in stool
Term
Canine Parvovirus Treatment
Definition
NPO
Fluid therapy
Plasma transfusion
Antibiotics
Antiemetics
Isolation
Keep warm, dry, clean
Wear protective clothing
Foot dip
Term
Canine Corona Virus
Definition
Shed in feces
By itself usually mild
Less damage to intestinal villi than parvo.
Term
Canine Corona Virus C. S.
Definition
Yellow-green to orange malodorous diarrhea - may have blood or mucus. May be persistent or intermittent for 3-4 weeks. Supportive therapy and isolation.
Term
Feline Panleukopenia
Definition
AKA Feline parvovirus/feline infectious anemia/feline distemper, highly contagious, often fatal, most severe in kittens. Affects rapidly growing and dividing cells such as in the bone marrow, lymph tissue, intestinal epithelium, and cerbellum and retinas of young animals. In pregnant queens it will affect the kittens w/ embryonic death, mummification, abortion, stillbirth, cerebellar hypoplasia.
Transmitted oronasally. Virus is abundant in all secretions and can survive in the environment over a year.
Term
Feline Panleukopenia C. S.
Definition
Most are subclinical
Most patients manifest illness under 1 yr.
Fever/Depression/Anorexia
Vomiting/Diarrhea/Dehydration
Abdominal pain
Thickened intestinal loop
Cerebellar hypoplasia
High mortality in kittens.
Term
Feline Panleukopenia Treatment
Definition
Vigorous fluid therapy
Dextrose and KCl
Antibiotics
Plasma/whole blood transfusion
Antiemetics
Term
Bacterial Diarrhea
Definition
Bacteria invade and damage intestinal epithelium, release enterotoxins which stimulate secretions, attach to mucosal surfaces, and produce cytotoxins
Term
3 Gram (-) Bacterial infections
Definition
Salmonella
Campylobacter
Escherichia coli
Term
2 Gram (+) Bacterial infections
Definition
Clostridium
Staphylococcus
Term
M.C. allegens in dogs
Definition
Beef, soy, chicken, milk, corn, wheat, eggs (but any protein can be involved)
Term
M.C. allergens in cat
Definition
Fish, beef, dairy
Term
Adenocarcinoma
Definition
More common in cat than dog, usually in older animals
Term
Lymphosarcoma
Definition
More common in cat than dog, may occur at any age, but more common in older animals.
Term
Intussuseption
Definition
when a smaller, proximal segment of the intestine invaginates in the larger portion of the large bowel (often occurs at a junction such as illium/colon junction)
Term
Megacolon
Definition
loss of normal colonic function, usually a dysfunction of colonic smooth muscles, results in sever fecal impaction and colonic distenstion. Occurs in older, obese cats.
Term
3 Rectoanal Diseases
Definition
Perineal hernia
Perianal fistula
Perianal gland tumor (m.c.)
Term
Most Common Rectoanal Disease
Definition
Perianal gland tumor
Term
Perineal
Definition
Around the perineum
Term
Perineal hernia
Definition
Protusion of a hernial sac in the perineal area. Usually occurs in intact male dogs >6-8 yrs.
Term
Perineal hernia - Clinical Signs
Definition
Is reducible. Causes pain on defecation, irregular bowel movements, constipation, rectal deviation
Term
Reducible
Definition
Able to be manipulated back thru the hernia.
Term
Herniorrhaphy
Definition
Surgical treatment for a perineal hernia involving stiching and reinforcing the lesion.
Term
Perianal fistula
Definition
An abnormal opening in the perianal area. Can be single or multiple ulcerated sinuses - draining tracts. Usually occurs in large breed dogs, such as German Shepherds and Irish Setters.
Term
Perianal Fistula - Clinical Signs
Definition
Onset is insidious and goes undetected initially. Excess licking of perianal area, fecal incontinence, tenesmus, constipation. Perianal hemorrhage, foul odor and thick discharge, personality change, pain on raising tail
Term
Tenesmus
Definition
straining to defecated
Term
Perianal fistula - treatment
Definition
Immunosuppresion, cyclosporine, asathioprine, prednisone. Surgical correction and anal sac removal
Term
Perianal gland tumor or Perianal adenoma
Definition
benign androgen dependent tumor. Seen in older, intact male dogs. Can be ulcerated, hemorrhage, or infection. Large tumors can be obstructive
Term
Perianal gland tumor - Clinical Signs
Definition
Excessive licking of perianal region, masses around anus/tailhead/inguinal region/prepuce, ulcerated/bleeding masses, may be an incidental finding
Term
Perianal gland tumor - diagnosis
Definition
FNA, histiopathology, intact older male dog
Term
Perianal Gland Tumor - Treatment
Definition
neuter, excise mass, radiation therapy, cryosurgery, estrogen therapy
Term
Hepatic portal system
Definition
GI tract blood drains directly into liver.
Term
hepatocyte
Definition
produces bile to emulsify and break down fat, gluconeogenesis
Term
gluconeogenesis
Definition
making glucose from a non-carb source
Term
Acute toxin induced liver disease
Definition
acute failure when 70-80% of functional mass is injured. Most susceptible to ingested toxins, chronic damage may occur with long term drug use
Term
6 Types of Drugs that can cause Acute toxin induced liver disease
Definition
Acetaminophen
Phenobarbital
Antifungals
Anabolic steroids
NSAIDs
Diazepam - cats
Term
Acute Toxin Induced Liver Disease - Clinical Signs
Definition
Acute onset of signs: Vomiting, diarrhea, constipation, PU/PD, jaundice, melena, hematuria, CNS depression, ataxia, dementia, blindness, seizures, coma
Term
Acute toxin induced liver disease - Diagnosis
Definition
Hx of drug administration or accidental ingestion, painful liver, hepatomegaly, increased ALT/ALKP/bilirubin/bile acids/ammonia, hypoglycemia, coagulopathy
Term
Acute toxin induced liver disease - Tx
Definition
Antidotes, induce vomiting, activated charcoal, supportive therapy
Term
5 Drugs that induce Chronic toxin induced liver disease
Definition
Anticonvulsants
Glucocorticoids
Methimazole
Antifungals
NSAIDs
Term
Chronic toxin induced liver disease - CS
Definition
Same as for acute, but happen over a longer period of time (insidious onset)- vomiting, diarrhea,constipation, PU/PD, jaundice, melena, hematuria, CNS signs
Term
Chronic toxin induced liver disease - Dx
Definition
History of long term drug use, increased ALT/ALKP/Bile acids, decreased albumin/cholesterol, liver biopsy
Term
Chronic toxin induced liver disease - Tx
Definition
Stop administering the drug, low-protein diet, supportive therapy, antibiotics if needed, feeding tube if needed
Term
Infectious Canine Hepatitis
Definition
Vaccinate with canine adenovirus 1 to prevent. Causes hepatic necrosis in dogs. Oronasal transmission. Virus replicates in the tonsils and lymph nodes. Localizes in the liver.
Term
Infectious Canine Hepatitis - C.S.
Definition
Usually occurs in dogs under 1 yr, petechial hemorrhage, hepatomegaly, corneal opacities (blue eye)
Term
Infectious Canine Hepatitis - Dx
Definition
CBC - thrombocytopenia, increased ALT, serum titer
Term
Infectious Canine Hepatitis - Tx
Definition
supportive therapy, force feed, blood transfusion
Term
Cholangiohepatitis
Definition
A common hepatobiliary disorder in cats. Bile duct and liver inflammation, commonly see pancreatitis.
Term
Cholangiohepatitis - CS
Definition
Vomiting, diarrhea, anorexia, wt. loss, fever, icterus, hepatomegaly
Term
Cholangiohepatitis - Dx
Definition
Increased ALT/ALKP, normal to increased Bile acids, hypoalbuminemia, decreased BUN
Term
Cholangiohepatitis - Tx
Definition
long term antibiotics, ursodeoxycholic acid, prednisone, fluids, nutritional support, vitamin therapy
Term
Hepatic Lipidosis
Definition
The m.c. hepatopathy in cats, occurs in adult, obese cats, stress often triggers, occurs d.t. accumulation of fat withn the hepatocyte, results in hepatic failure, can be caused by prolonged caloric restriction in obese cats
Term
Hepatic Lipidosis - CS
Definition
Anorexia, obesity, wt. loss of >25% of body weight, depression, icterus, hepatomegaly, salivation, pancreatitis
Term
Hepatic Lipidosis - Dx
Definition
Increased ALT/ALKP/Bilirubin/Bile acids, hypoalbuminemia, rads, ultrasounds, liver biopsy
Term
Hepatic Lipidosis - Tx
Definition
Often it is reversible, fluids and electrolyte therapy, aggressive nutrional support, high protein/caloric dense diet, antiemetics, diazepam/metoclopramide to stimulate appetite
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