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Vert Phys
Respiratory
33
Biology
Undergraduate 2
11/12/2009

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Term
What is the circulation pathway of air from atmosphere back to atmosphere?
Definition
atmosphere--aveoli--pulmonary circulation--systemic circulation--cell--cardiac waste--systemic circulation--pulmonary circulation--atmosphere
Term
Why does the body need glucose?
Definition
to produce ATP via glycolysis and to shuttle O2 and waste products
Term
What happens to the carrying capacity for O2 in the RBCs if you increase acidity?
Definition
lowers carrying capacity and alters enzymatic reactions
Term
What are the characteristics of oxygen?
Definition
low soluability in fluids, high energy tissues need a lot of oxygen
Term
what are respiratory pigments?
Definition
they are responsible for binding oxygen, carbon dioxide, and hydrogen. They carry a lot of the molecules via the bloodstream.
Term
Give an example of a respiratory pigment?
Definition
Hemoglobin.
Term
Explain why hemoglobin is a priniciple molecule for transport of gasses?
Definition
abundant; not heavy; high carrying capacity
Term
Describe the structure of hemeglobin.
Definition
4 hemes in which each heme can carry 1 molecule of oxygen; becomes saturated when there are 4 molecules attached to it. Contains 4 polypeptide chains (2 alpha and 2 beta).
Term
What part of the hemeglobin carries CO2?
Definition
polypeptide chains
Term
what change is responsible for sickle cell anemia?
Definition
exchange of a glutamine for a valene leading to a single point mutations that causes a decrease in the carrying capacity for oxygen
Term
What is the pathway of air in the lungs?
Definition
nasal passages--pharynx--trachea--larynx--R & L brochi--bronchioles--respiratory bronchioles--aveoli
Term
Where is the only location(s) for gas exchange?
Definition
aveoli. Respiratory brochioles if they have aveoli attached
Term
Which molecule does hemeglobin prefer to bind?
Definition
carbon dioxide
Term
Explain the association/dissociation kinetics curve.
Definition
association= increase partial pressure causes hemeglobin to associate easily with oxygen

disociation= decrease in partial pressure leads to a dumping of oxygen where needed
Term
what causes the Bohr Curve to shift right?
Definition
acidity; increase PC02, temperature increase, hypoventilation
Term
what causes the Bohr curve to shift left?
Definition
alkalinity, decrease PCO2, hypothermia, hyperventiliation
Term
What are the principle muscles involved in inhilation? deep inhilation?
Definition
external intercostals, parasternal intercostals, diaphragm

deep inhilation recruits: sternocleidomastoid and scalenes
Term
what muscles are involved in forced expiration?
Definition
internal intercostal, externa abdominal oblique, transverse abdominal, rectus abdominus
Term
What are the 3 cell types in Aveoli and what is their function?
Definition
type 1: covers surface

type 2: makes surfactant, develops tension

macrophages: engulf foreign particles
Term
define pathlength
Definition
distance oxygen molecule must travel from RBC to mitochandria
Term
define hypoxic hypoxia
Definition
not enough O2 in air leading to decreased O2 in lungs
Term
define stagnant hypoxia
Definition
inadequate blood flow
Term
define anemic hypoxia
Definition
inadequate carrying capacity
Term
define histotic hypoxia
Definition
drug blocking mitochandrial respiration
Term
define dyspnea
Definition
difficult unpleasant breathing

apnea: cessation of breathing
eurapnea: normal resting level of breathing
Term
Spirometry
Definition
helps diagnose respiratory diseases
Term
anatomical dead space
Definition
2mL per kg of body weight (V sub D)
Term
Tidal Volume Equation
Definition
TV= aveolar ventilation + dead space
Term
total ventilation/min
Definition
VsubE= TV x ventilation
Term
aveolar ventilation
Definition
ventilation X the difference of TV and dead space
Term
TV
Definition
tidal volume
Term
IRV
Definition
inspiration reserve capacity; peak of normal breathing to peak of inspiration
Term
IC
Definition
inspiratory capacity; peak if inspiration to trough of normal breathing
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