Term
|
Definition
Relaxes sm. m. resulting in rapid venous dilation, slower artery dilation, and even slower arterial dilation
Main effect: REDUCED LVEDV (PRELOAD) |
|
|
Term
|
Definition
Nitroglycerin
Isosorbide dinitrate |
|
|
Term
| Organic nitrates considerations |
|
Definition
| Combine w beta-blocker to prevent reflexinve tachycardia w dec BP |
|
|
Term
| Organic nitrate side effects |
|
Definition
orthostatic hyopTN
tachycardia
HA
TOLERANCE
dizziness, flushing, syncope |
|
|
Term
| Organic nitrate tolerance |
|
Definition
May develop w continuous or freq use
Avoid w nitrate-free periods of at least 8 hrs |
|
|
Term
|
Definition
No first-pass effect
2-4 min onset
30-60 min duration |
|
|
Term
|
Definition
first-pass effect
10-20 min onset
2-3 hr duration |
|
|
Term
|
Definition
|
|
Term
| Transdermal nitroglycerin |
|
Definition
Slow onset
Variable duration (10-24 hrs)
Nocturnal angina |
|
|
Term
|
Definition
rapid onset
difficult to control |
|
|
Term
| Sublingual Isosorbide dinitrate |
|
Definition
organic nitrate
onset 2-4 min
duration 2-4 hrs |
|
|
Term
| Oral isosorbide dinitrate |
|
Definition
organic nitrate
onset 10-20 min
duration 4-8 hrs |
|
|
Term
| Calcium Channel Blocker effects |
|
Definition
Improve O2 delivery to myocardium by VASODILATING CORONARY AA.
Reduce myocardial O2 consumption by REDUCING AFTERLOAD
Reduce mycoardial O2 consumption by REDUCING HR AND CONTRACTILITY
**Binding of Ca channels is dependent on membrane potential |
|
|
Term
| Type I Calcium channel blockers |
|
Definition
Verapamil
Diltiazem
Both slow HR and dec contractility
Verapamil dilates coronary and periph more
Diltiazem dilates coronary most |
|
|
Term
|
Definition
CARDIODEPRESSION
hypoTN
AV block
periph edema |
|
|
Term
|
Definition
minor hypoTN
periph edema
AV block
cardiodepression |
|
|
Term
|
Definition
Beta-adrenergic antagonist
dec HR
dec contractility |
|
|
Term
| Calcium channel blocker considerations |
|
Definition
|
|
Term
| Beta-blocker considerations |
|
Definition
| Good for pts w prior MI, reduces SCD |
|
|
Term
|
Definition
Type II Calcium channel blocker
Predominantly vascular effects |
|
|
Term
|
Definition
|
|
Term
|
Definition
Good periph and coronary vasodilator
INC HR and CONTRACTILITY |
|
|
Term
| Phosphodiesterase type 5 inhibitor |
|
Definition
Sildenifil
Inc cGMP levels in vasuclar sm m
Used for erectile dysfx |
|
|
Term
|
Definition
Potentially fatal reduction in BP w nitrates
Flushing, dyspepsia
Abnormal vision |
|
|
Term
| Sildenifil pharmacokinetics |
|
Definition
| 4 hr half-life, longer in men over 65 or renal insufficiency |
|
|
