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Vasculitites
Pathology of the BVs
40
Medical
Graduate
05/20/2010

Additional Medical Flashcards

 


 

Cards

Term
Pathogenesis of HSP
Definition
In susceptible people, Ag exposure from a preceding bacterial or viral infx leads to IgA production. IgA and Ag complexes deposit in the wall of small blood vessels, activates compliment and causes inflammation. Causes skin rash and renal involvement.
Term
Sx of HSP
Definition

Sx: Child 3-10 yo

Abdominal: Pain, hemorrhage, melena

palpable purpura skin rash on legs and ass

arthralgias

renal involvement (proteinuria)

Multiple lesions of the same age

Term
c-ANCA positive
Definition
Wegener's Granulomatosis
Term
necrotizing granulomas in the lung and upper airway and necrotizing GN
Definition
Wegener's granulomatosis
Term
Tx of Wegener's
Definition
Cyclophosphamide and coricosteroids
Term
Sx of Wegener's 
Definition

Perforation of nasal septum

chronic sinusitis,

otitis media

mastoidits

cough

dypnea

hemoptysis

hematuria

 

Term
p-ANCA
Definition

Chrug-Strauss syndrome

Microscopic Polyangiitis

Term
Vessels affected by Wengener's
Definition
Small vessles
Term
Vessels affected by Churg-Strauss
Definition
Small Vessels
Term
Vessels affected by microscopic polyangiitis
Definition
Small vessels
Term
Leptomeningeal Angiomatosis
Definition
Sturge-Weber Dz
Term
Port Wine Stain
Definition
Sturge-Weber Syndrome
Term
Vessels affected by HSP
Definition
Small
Term

Vasculitis that affects the following triad:

Skin

Joints

GIT

 

 

Definition
HSP
Term
Vasculitis that follows URI
Definition
HSP
Term
Vasculitis a/w heavy smokers
Definition
Buerger's/thromboangiitis obliterans
Term
Vasculitis a/w severe pain, gangrene and autoamputation of affected digits
Definition
Buerger's
Term
Vessels affected by Buerger's
Definition

Small and MEDIUM sized vessels

 

(medium vessels dzs cause infarction/thrombosis of arteries)

Term
Fever, congested conjuctivea, changes in lips/oral mucosa, lymphadenitis in children
Definition
Kawasaki's Dz
Term
Vasculitis a/w "strawberry tongue"
Definition
Kawasaki's
Term
Vessels affected by Kawasaki's dz
Definition
small and medium
Term
Tx for Kawasaki's Dz
Definition
None, it's self-limiting
Term
Vasculitis a/w Asian infants/children
Definition
Kawasaki's Dz
Term
Vasculitis a/w necrotising immune complex inflammation of medium-sized muscular arteries
Definition
PAN
Term

Vasculitis presenting w/:

Fever

weight loss

malaise

abd pain

melena

HA

myalgia

HTN

neurologic dysf(x)

cutaneous erruptions

Definition
PAN
Term

Vasculitis w/ lesions of the same age

 

Lesions of different ages

Definition

Same age: HSP

Different age: PAN

Term
Vessels affected by PAN
Definition
Medium/Muscular arteries
Term
Vasculitis a/w HBV seropositivity
Definition
PAN
Term
Tx for PAN
Definition
Corticosteroids, cyclophosphamide
Term
Pulseless Dz
Definition
Takayasu's arteritis
Term
Vessels affected by Takayasu's
Definition
medium and large
Term
Granulomatous thickening of aortic arch and/or proximal great vessels
Definition
Takayasu's Arteritis
Term
Vasculitis that affects Asian females < 40 yo
Definition
Takayasu's Arteritis
Term

Fever

arthritis

nightsweats

myalgia

skin nodues

ocular disturances

weak pulses

Definition
Takayasu's Arteritis
Term
Vessels affected by Temporal Arteritis
Definition

Medium and Large arteries

usually branches of carotid artery

Term
MC vasculitis of medium and larger arteries
Definition
Temporal arteritis
Term
focal granulomatous inflammation of medium and large vessels
Definition
Temporal arteritis
Term
Vasculitis that affects primarily elderly females
Definition
Temporal arteritis
Term
Tx for Temporal arteritis
Definition
High dose steroids
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