Term
|
Definition
| Chinese developed variolation ( introducting antigen to wound) |
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Term
| What was the first vaccine ? |
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Definition
|
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Term
| 1754 inoculation against what? |
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Definition
Rinderpest
( 1st veterinary Vx) |
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Term
| In 1976 who im poroved variolation? |
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Definition
|
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Term
| 1879 what did Louis Pasteur do? |
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Definition
| Attenuated organism (birds) |
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Term
| What type of Vx is salmonella and who made it? |
|
Definition
| Killed organism and Salmon |
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Term
| Who used no oragnisms Vx essentially used antibodies? |
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Definition
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Term
| What is meant by passive immunity? |
|
Definition
|
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Term
| Mechanism of passive immunity? |
|
Definition
|
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Term
|
Definition
| when an antigen stimulates immune response |
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Term
| What are the mechanisms / propertiesof active immunity? |
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Definition
Protection is not conferred immediatly (body has to build it)
Long lasting
Capable of restimulation
artifical |
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Term
Types of biologicals
Antiserum |
|
Definition
| Serum that contains specific antibodies |
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Term
| What immune response does antiserum belong to |
|
Definition
|
|
Term
Types of biologicals
Antitoxin
|
|
Definition
| Antiserum directed against a toxin |
|
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Term
| Which immunse response does Antitoxin belong to? |
|
Definition
|
|
Term
Types of biologicals
Toxoid
|
|
Definition
Non toxic derivatives of toxins used as antigens
( doesnt last long so levels won't be as high) |
|
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Term
| Which immune resonse does toxoid belong to ? |
|
Definition
|
|
Term
Types of biologicals
Bacterin
|
|
Definition
| A preparation of a killed bacteria used for immunization |
|
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Term
| Which immune response does bacterin belong to ? |
|
Definition
|
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Term
| What is an attenuated vaccine? |
|
Definition
| The reduction of a virulence of an infectious agent |
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Term
|
Definition
| Weakening abilty to cause Dz |
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Term
| What is an inactivated vaccine? |
|
Definition
Treatment of an ingfectious agent so that it can no longer replicate
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|
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Term
| What is an adjuvant vaccine? |
|
Definition
Any substance that when given with / added to an antigen enhances the immune response to that antigen
( greater response) |
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Term
Living Vs. Killed
Few inoculating doses required |
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Definition
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|
Term
Living Vs. Killed
Adjuvants unnecessary
|
|
Definition
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|
Term
|
Less chance of hypersensativity
|
|
Definition
|
|
Term
Living Vs. Killed
Relativley inexpensive
|
|
Definition
|
|
Term
Living Vs. Killed
Induction of interferon
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|
Definition
|
|
Term
Living Vs. Killed
Residual virulence
(maintains ability to go viral)
|
|
Definition
|
|
Term
Living Vs. Killed
Stable on storage
|
|
Definition
|
|
Term
Living Vs. Killed
Unlikey to cause Dz
|
|
Definition
|
|
Term
Living Vs. Killed
Unlikey to contain contaminating organisms
|
|
Definition
|
|
Term
| How many categories are included in the USDA classification of genetically enegineered biologicals? |
|
Definition
|
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Term
|
Definition
| Vaccines that contain purified antigens derived from recombient organisms |
|
|
Term
| What are the 2 vaccines that contain purified organisms from recombient organisms? |
|
Definition
|
|
Term
|
Definition
| Vaccines containing live organisms that contain gene deletions |
|
|
Term
| One example of a Class II vaccine |
|
Definition
|
|
Term
| What is an igredient in Pseudo rabies? |
|
Definition
Thymidine Kinase
( necessary for reproduction of organism) |
|
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Term
|
Definition
| Contain live expression vectors containing heterologous genes for immunizing antigens |
|
|
Term
| Example of a catergory III vaccine |
|
Definition
|
|
Term
| What is an oral rabies bait |
|
Definition
|
|
Term
| Rule of vaccine assessing |
|
Definition
| Must be sure that the risks of vaccination o not exceed those associated witht he chance of contracting the disease itself |
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|
Term
% of controls dieing - % of vaccinates dieing
Over % of controls dieing |
|
Definition
|
|
Term
| What probability does herd immunity reduce? |
|
Definition
Susceptible animal meeting an infected on
Disease is slowed or terminated |
|
|
Term
| Immunity conferred on a population as a result of the presence of immune individuals within that population |
|
Definition
| Herd immunity * livestock |
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|
Term
T/ F
When administering vaccine doses should always be split never using full doses. |
|
Definition
|
|
Term
T / F
Vaccines don't have a designated shelf life? |
|
Definition
|
|
Term
T / F
Vaccines that have to be reconsitiuted can be done with any of the vaccine reconstitution agents? |
|
Definition
|
|
Term
| Different ways Vx can be manufactured |
|
Definition
Modified live
Inactivated
Purified subunits
Recombiant
Dna (usually reseach) |
|
|
Term
| Licensing of Veterinary Vx |
|
Definition
USDA--->
Animal Plant Health Inspection Service ---->
Veterinary Services (dept within) ---->
*Center for Veterinary Biologics * |
|
|
Term
Adverse consequence of Vx
"normal" toxicity |
|
Definition
Fever
Malaise
Inflammation
Pain |
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