Term
______ is converted to estradiol |
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Definition
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Term
high levels of estrogen feed back on the hypotalmus to decrease_______ |
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Definition
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Term
Follicle develops in response to rising ___ levels |
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Definition
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Term
the spike in ___ stimulates ovulation |
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Definition
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Term
primary estrogen in premenpausal women |
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Definition
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Term
primary estrogen in postmenopausal women |
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Definition
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Term
estrogen produced during pregnancy |
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Definition
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Term
ethinyl-estradiol mestranol dienestrol |
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Definition
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Term
delayed onset and prolonged duration of action aqueous solutions have rapid onset suspensions or solutions have delayed onset and are long acting |
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Definition
synthetic estrogen characteristics |
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Term
clinical uses of estrogen therapy |
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Definition
hormonal deficiency replacement therapy abnormal uterine bleeding contraception |
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Term
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Definition
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Term
clinical uses of estrogen therapy |
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Definition
hormonal deficiency replacement therapy abnormal uterine bleeding contraception |
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Term
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Definition
help menopause symptoms, prevent osteoporosis |
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Term
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Definition
< 5 years to avoid cardivascular incidents, stoke, ovarian cancer |
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Term
When should HRT be initiated |
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Definition
slightly before menopause |
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Term
Drug interactions of estrogens |
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Definition
decrease effects of anticoagulants and hypoglecemics increase adverse effects of TCAs, increase effects of oxytocin |
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Term
this supplement may interefere with contraceptive efficacy |
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Definition
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Term
Adverse Effects of estrogen therapy |
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Definition
nausea, endocrine changes, cancer, THROMBOEMBOLIC disorders |
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Term
Contraindications of Estrogen therapy |
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Definition
pregnancy, cardivascular disease, breast and uterine cancer, thromboembolic disease, smoking |
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Term
these are antagonists that bind to both ERalpha and ER beta |
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Definition
selective estrogen receptor modulators |
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Term
SERMs are used for _________ |
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Definition
estrogen recepto-positive cancers |
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Term
SERMs are typically metabolized by the ______ |
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Definition
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Term
gold standard SERM that acts as an antagonist in breast tissue used to prevent breast cancer in pre-menopausal women |
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Definition
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Term
side effects of tamoxifen |
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Definition
increased risk of endometrial cancer and venous thromboembolism |
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Term
contraindications of tamoxifen |
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Definition
selective serotonin reuptake inhibitors |
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Term
this SERM is used to prevent osteoporosis or to prevent breast cancer in high risk post-menopausal women |
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Definition
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Term
Raloxifene should not be taken with |
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Definition
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Term
this SERM is used in the treatment metastic breast cancer for advanced-stage post menopausal women |
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Definition
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Term
this SERM is used in the treatment metastic breast cancer for advanced-stage post menopausal women |
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Definition
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Term
this SERm can enhance the effects of Warfarin |
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Definition
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Term
these reduce estrogen production by inhibiting the aromatase enzyme |
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Definition
Aromatase Inhibitors (AIs) |
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Term
Anastrozole (Armidex) Letrozole (Femara) Exemestane (Aromasin) |
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Definition
Aromatase Inhibitors (AIs) |
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Term
these are superior to SERMs in treating postmenopausal women with less risk of thromboembolic events and endometrial cancer |
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Definition
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Term
AIs are currently used in ______ therapy |
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Definition
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Term
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Definition
osteoporosis, follicular growth in premenopausal women, joint pain after discontinuation |
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Term
used with estrogens for menopausal hormone replacement therapy to limit estrogen's effect on the endometrium |
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Definition
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Term
progesterone can be used with estrogen as a ________ |
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Definition
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Term
Mifepristone (Mifeprex RU-486) |
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Definition
Progesterone Receptor Modulators |
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Term
abortion pill- acts as a progesterone receptor antagonist; acts at the uterus lining; do not use for ectopic pregnancy |
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Definition
Mifepristone (Mifeprex; RU-486) |
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Term
this fertility drug blocks estrogen receptos and interferes with feedback increasing FSH and LH |
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Definition
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Term
multiple births can occur r/t this fertility drug |
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Definition
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Term
contraindications of Clomiphene citrate |
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Definition
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Term
these fertility drugs induce follicular maturation and ovulation due to increase in both FSH and LH activity |
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Definition
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Term
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Definition
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Term
adverse effects of menotropins |
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Definition
ovarian hyperstimulation syndrome, ascites, pain, bleeding |
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Term
these fertility drugs are similar to menotropins but only exhibit FSH activity |
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Definition
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Term
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Definition
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Term
similar in structure and action to LH thus induces ovulation by stimulating the midcycle LH surge |
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Definition
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Term
this dopamine agonist inhibits prolactin release, increases fertility, and may cause nausea |
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Definition
Bromocriptin mesylate (Parolodel) |
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Term
drug of choice to stimulate uterine contraction to induce labor |
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Definition
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Term
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Definition
fetal distress if delivery is not imminent and can have antidiuretic effects and cause water intoxication |
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Term
these do stimulate uterine contractions but are not used to induce labor they are used to control post partum/abortion bleeding and aid in delivery of placenta |
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Definition
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Term
side effects of ergot alokaloids |
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Definition
severe hypertension, cramping |
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Term
used to control postpartum hemorrhage, and stimulate smooth muscle contraction of the GI and respiratory tract |
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Definition
Prostaglandins (Carboprost) |
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Term
this prostaglandin promotes cervical ripening |
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Definition
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Term
This tocolytic can delay preterm labor for 48-72 hours increase risk of muscle weakness and respiratory arrest |
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Definition
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Term
adverse effects of magnesium sulfate |
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Definition
can cross the placenta, pulmonary edema, do not use in pts with myasthenia gravis |
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Term
this tocolytic stimulates B2 receptors in the uterus |
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Definition
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Term
what is the off label use of terabutaline sulfate? |
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Definition
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Term
terbutaline has a wide range of adverse effects including |
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Definition
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Term
concentations of estrogens and progestins are fixed in the the pill |
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Definition
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Term
in this contraceptive estrogen is low and fixed and progestin is low during the first week then increases two-fold over the remainder of the cycle |
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Definition
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Term
estrogen is fixed but progestin levels vary: low-high-low |
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Definition
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Term
gradual estrogen intake and steady progestin intake |
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Definition
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Term
these birthcontrols have low androgenic activity and can reduce acne |
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Definition
ortho tri cyclen/ ortho tri cyclen low |
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Term
placebo free pill w/ 4 periods per year |
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Definition
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Term
this birthcontrol increases the viscosity of the cervical mucous; modifies the endometrium. weakly inhibits ovulation |
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Definition
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Term
A single capsule composed of progestin- long acting implant |
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Definition
subdermal implant (implanon) |
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Term
Mechanism of action hormonal IUD |
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Definition
supresses proliferation of endometrial lining |
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Term
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Definition
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Term
very high doses of progesterone that inhibits ovulation and effects the uterus can be used within 72 hours to prevent pregnancy |
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Definition
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Term
Clinical uses of androgens in males |
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Definition
anemia, wasting, stimulate libido |
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Term
clinical uses of androgens in females |
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Definition
metastatic breast malignancies, stimulation of libido, can relieve some menopausal symptoms |
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Term
adverse effects of androgens in males |
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Definition
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Term
adverse effects of androgens in females |
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Definition
female virilization (masculinization) effects menstruation category X |
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Term
negative effects of androgens in both sexes |
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Definition
stunted growth in young people |
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Term
flutamide (eulexin, drogenil) bicalutamide (casodex) |
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Definition
androgen receptor antagonists |
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Term
these are used to treat metastic prostate cancer and hirsutism in ladies |
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Definition
androgen recpetor antagonists |
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Term
this androgen receptor antagonist is less hepatotoxic than flutamide |
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Definition
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Term
these are used to take benign prostatic hyperplasia and treat male pattern baldness |
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Definition
5 alpha reductase inhibitors |
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