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Uterus drugs
uterus drugs
80
Pharmacology
Undergraduate 2
03/17/2011

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Term
______ is converted to estradiol
Definition
testosterone
Term
high levels of estrogen feed back on the hypotalmus to decrease_______
Definition
GnRH
Term
Follicle develops in response to rising ___ levels
Definition
FSH
Term
the spike in ___ stimulates ovulation
Definition
LH
Term
primary estrogen in premenpausal women
Definition
ESTRADIOL
Term
primary estrogen in postmenopausal women
Definition
estrone
Term
estrogen produced during pregnancy
Definition
estriol
Term
ethinyl-estradiol
mestranol
dienestrol
Definition
synthetic estrogens
Term
delayed onset and prolonged duration of action
aqueous solutions have rapid onset
suspensions or solutions have delayed onset and are long acting
Definition
synthetic estrogen characteristics
Term
clinical uses of estrogen therapy
Definition
hormonal deficiency
replacement therapy
abnormal uterine bleeding
contraception
Term
HRT
Definition
Term
clinical uses of estrogen therapy
Definition
hormonal deficiency
replacement therapy
abnormal uterine bleeding
contraception
Term
Benefits of HRT
Definition
help menopause symptoms, prevent osteoporosis
Term
recommended time for HRT
Definition
< 5 years to avoid cardivascular incidents, stoke, ovarian cancer
Term
When should HRT be initiated
Definition
slightly before menopause
Term
Drug interactions of estrogens
Definition
decrease effects of anticoagulants and hypoglecemics
increase adverse effects of TCAs, increase effects of oxytocin
Term
this supplement may interefere with contraceptive efficacy
Definition
St. John's Wort
Term
Adverse Effects of estrogen therapy
Definition
nausea, endocrine changes, cancer, THROMBOEMBOLIC disorders
Term
Contraindications of Estrogen therapy
Definition
pregnancy, cardivascular disease, breast and uterine cancer, thromboembolic disease, smoking
Term
these are antagonists that bind to both ERalpha and ER beta
Definition
selective estrogen receptor modulators
Term
SERMs are used for _________
Definition
estrogen recepto-positive cancers
Term
SERMs are typically metabolized by the ______
Definition
liver
Term
gold standard SERM that acts as an antagonist in breast tissue used to prevent breast cancer in pre-menopausal women
Definition
Tamoxifen (Nolvadex)
Term
side effects of tamoxifen
Definition
increased risk of endometrial cancer and venous thromboembolism
Term
contraindications of tamoxifen
Definition
selective serotonin reuptake inhibitors
Term
this SERM is used to prevent osteoporosis or to prevent breast cancer in high risk post-menopausal women
Definition
Raloxifene (Evista)
Term
Raloxifene should not be taken with
Definition
Warfarin
Term
this SERM is used in the treatment metastic breast cancer for advanced-stage post menopausal women
Definition
Toremifene (Fareston)
Term
this SERM is used in the treatment metastic breast cancer for advanced-stage post menopausal women
Definition
Toremifene (Fareston)
Term
this SERm can enhance the effects of Warfarin
Definition
Toremifene
Term
these reduce estrogen production by inhibiting the aromatase enzyme
Definition
Aromatase Inhibitors (AIs)
Term
Anastrozole (Armidex)
Letrozole (Femara)
Exemestane (Aromasin)
Definition
Aromatase Inhibitors (AIs)
Term
these are superior to SERMs in treating postmenopausal women with less risk of thromboembolic events and endometrial cancer
Definition
AIs
Term
AIs are currently used in ______ therapy
Definition
adjuvant
Term
side effects of AIs
Definition
osteoporosis, follicular growth in premenopausal women, joint pain after discontinuation
Term
used with estrogens for menopausal hormone replacement therapy to limit estrogen's effect on the endometrium
Definition
progesterone
Term
progesterone can be used with estrogen as a ________
Definition
contraceptive
Term
Mifepristone (Mifeprex RU-486)
Definition
Progesterone Receptor Modulators
Term
abortion pill- acts as a progesterone receptor antagonist; acts at the uterus lining; do not use for ectopic pregnancy
Definition
Mifepristone (Mifeprex; RU-486)
Term
this fertility drug blocks estrogen receptos and interferes with feedback increasing FSH and LH
Definition
clomiphene citrate
Term
multiple births can occur r/t this fertility drug
Definition
clomiphene citrate
Term
contraindications of Clomiphene citrate
Definition
pregnancy
Term
these fertility drugs induce follicular maturation and ovulation due to increase in both FSH and LH activity
Definition
Menotropins
Term
Pergonal
Repronex
Menopur
Definition
Menotropins
Term
adverse effects of menotropins
Definition
ovarian hyperstimulation syndrome, ascites, pain, bleeding
Term
these fertility drugs are similar to menotropins but only exhibit FSH activity
Definition
Follitropins
Term
Metrodin
Gonal-F
Follistim
Definition
Follitropins
Term
similar in structure and action to LH thus induces ovulation by stimulating the midcycle LH surge
Definition
HCG
Term
this dopamine agonist inhibits prolactin release, increases fertility, and may cause nausea
Definition
Bromocriptin mesylate (Parolodel)
Term
drug of choice to stimulate uterine contraction to induce labor
Definition
oxytocin
Term
side effects of oxytocin
Definition
fetal distress if delivery is not imminent and can have antidiuretic effects and cause water intoxication
Term
these do stimulate uterine contractions but are not used to induce labor they are used to control post partum/abortion bleeding and aid in delivery of placenta
Definition
Ergot alkaloids
Term
side effects of ergot alokaloids
Definition
severe hypertension, cramping
Term
used to control postpartum hemorrhage, and stimulate smooth muscle contraction of the GI and respiratory tract
Definition
Prostaglandins (Carboprost)
Term
this prostaglandin promotes cervical ripening
Definition
dinoprostone
Term
This tocolytic can delay preterm labor for 48-72 hours increase risk of muscle weakness and respiratory arrest
Definition
Magnesium sulfate
Term
adverse effects of magnesium sulfate
Definition
can cross the placenta, pulmonary edema, do not use in pts with myasthenia gravis
Term
this tocolytic stimulates B2 receptors in the uterus
Definition
terbutaline sulfate
Term
what is the off label use of terabutaline sulfate?
Definition
to prevent preterm labor
Term
terbutaline has a wide range of adverse effects including
Definition
pulmonary edema
Term
concentations of estrogens and progestins are fixed in the the pill
Definition
monophasic
Term
in this contraceptive estrogen is low and fixed and progestin is low during the first week then increases two-fold over the remainder of the cycle
Definition
biphasic
Term
estrogen is fixed but progestin levels vary: low-high-low
Definition
triphasic
Term
gradual estrogen intake and steady progestin intake
Definition
estrophasic
Term
these birthcontrols have low androgenic activity and can reduce acne
Definition
ortho tri cyclen/ ortho tri cyclen low
Term
placebo free pill w/ 4 periods per year
Definition
seasonique
Term
this birthcontrol increases the viscosity of the cervical mucous; modifies the endometrium. weakly inhibits ovulation
Definition
progesterone mini pills
Term
A single capsule composed of progestin- long acting implant
Definition
subdermal implant (implanon)
Term
Mechanism of action hormonal IUD
Definition
supresses proliferation of endometrial lining
Term
complications of IUD
Definition
PID, STD
Term
very high doses of progesterone that inhibits ovulation and effects the uterus can be used within 72 hours to prevent pregnancy
Definition
Plan B (levonorgestrel)
Term
Clinical uses of androgens in males
Definition
anemia, wasting, stimulate libido
Term
clinical uses of androgens in females
Definition
metastatic breast malignancies, stimulation of libido, can relieve some menopausal symptoms
Term
adverse effects of androgens in males
Definition
gynecomastia
Term
adverse effects of androgens in females
Definition
female virilization (masculinization) effects menstruation category X
Term
negative effects of androgens in both sexes
Definition
stunted growth in young people
Term
flutamide (eulexin, drogenil)
bicalutamide (casodex)
Definition
androgen receptor antagonists
Term
these are used to treat metastic prostate cancer and hirsutism in ladies
Definition
androgen recpetor antagonists
Term
this androgen receptor antagonist is less hepatotoxic than flutamide
Definition
bicalutamide
Term
these are used to take benign prostatic hyperplasia and treat male pattern baldness
Definition
5 alpha reductase inhibitors
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