Term
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Definition
GnRH analog; agonist when pulsatile, antagonist when continuous.
Infertility (pulsatile use), prostate cancer (continuous use), uterine fibroids
Anti-androgen sx, nausea, vomiting. |
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Term
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Definition
Direct androgen receptor agonist
Treat hypogonadism, develop secondary sex characteristics; stimulation of anabolism to promote recovery after burn or injury; treat ER-positive breast cancer.
Masculinization in females; reduces intratesticular testosterone in males (feedback inhibition), causing gonadal atrophy. Premature closure of epiphyseal plates. Raises LDL, lowers HDL. |
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Term
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Definition
aka Propecia
5-alpha-reductase inhibitor.
BPH, male pattern baldness. |
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Term
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Definition
Nonsteroidal competitive androgen inhibitor.
Prostate cancer. |
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Term
| Ethinyl estradiol, mestrinol |
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Definition
estrogen analogs
Hypogonadism, ovarian failure, menstrual abnormalities, hormone replacement therapy in post-menopausal women, androgen-dependent prostate cancer.
Increases endometrial carcinoma risk, bleeding in post-menopausal women, increased thrombosis risk. CI: ER positive breast cancer, history of DVTs. |
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Term
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Definition
SERM. Partial agonist at hypothalamus; prevents normal feedback inhibition, increases release of LH and FSH from pituitary, stimulates ovulation.
Infertility, PCOS.
Hot flashes, ovarian enlargement, multi-pregnancy, visual disturbances. |
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Term
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Definition
SERM. Antagonist on breast, partial agonist on uterus.
Treat ER-positive breast cancer.
Increase in endometrial cancer risk. |
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Term
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Definition
SERM. Agonist on bone; antagonist on breast AND uterus.
Osteoporosis.
No endometrial cancer risk (unlike tamoxifen) |
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Term
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Definition
Aromatase inhibitor.
Breast cancer in post-menopausal women. |
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Term
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Definition
Aromatase inhibitor.
Breast cancer in post-menopausal women. |
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Term
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Definition
aka DepoProvera
Progesterone analog. Reduce growth and increase vascularization of endometrium.
Oral contraceptive, treatment of endometrial cancer, abnormal bleeding. |
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Term
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Definition
aka RU-486
Competitive inhibitor of progesterone
Termination of pregnancy, give with misoprostol (PGE1)
Heavy bleeding, GI distress (N/V, anorexia), abdominal pain |
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Term
| Synthetic estrogen/progestin combo |
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Definition
Oral contraceptive. Prevents estrogen rise, LH surge, no ovulation.
Reliable contraception, decrease endometrial and ovarian cancer risk, decrease ectopic pregnancy risk, decrease pelvic infections, regular menses.
Must take daily, no STD protection, *increases triglycerides, *depression, weight gain, nausea, HTN, hypercoagulability.
CI: smokers > 35 years old - increase CV risk, history of thrombus, stroke, estrogen dependent tumor. |
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Term
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Definition
PGE2 analog: Causes cervical dilation, uterine contraction.
Induces labor. |
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Term
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Definition
B2-agonist, relaxes uterus.
tocolytic.
(baby "returns to dreams") |
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Term
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Definition
B2-agonist
relaxes uterus
tocolytic |
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Term
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Definition
PGE1 analog, uterine contractions
Terminate pregnancy (with mifepristone), induce labor |
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Term
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Definition
Inhibit cGMP phosphodiesterase, raise cGMP, smooth muscle relax in corpus cavernosum, erection.
Erectile dysfunction.
Headache, flushing, dyspepsia, impaired blue-green color vision. CI: nitrate use - severe hypotension (excess cGMP without PDE!)
3H: Headache, Heartburn, Hypotension |
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Term
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Definition
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Term
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Definition
| GnRH analog - see leuprolide |
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Term
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Definition
| GnRH analog - see leuprolide |
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Term
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Definition
| GnRH analog - see leuprolide |
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Term
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Definition
androgen aromatase inhibitor
breast cancer in post-menopausal women |
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