Term
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Definition
Aspirin (a salicylate)
IRREVERSIBLY inhibits COX by covalent binding. Decreased synthesis of prostaglandins and thromboxane.
Low dose for anti-platelet. Intermediate dose for antipyretic, analgesic. High dose for anti-inflammatory.
NSAID induced gastric ulcer, acute renal failure, interstitial nephritis. Reye's syndrome in children with fever (don't give under 12). Inhibits uric acid secretion (except at very high doses). |
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Term
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Definition
NSAID: reversibly inhibit COX.
Antipyretic, analgesic, anti-inflammatory.
Renal damage, fluid retention, aplastic anemia, GI upset, ulcers. |
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Term
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Definition
NSAID: reversibly inhibit COX.
Antipyretic, analgesic, anti-inflammatory.
Renal damage, fluid retention, aplastic anemia, GI upset, ulcers. |
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Term
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Definition
NSAID: reversibly inhibit COX.
Antipyretic, analgesic, anti-inflammatory. Indomethacin also for PDAs.
Renal damage, fluid retention, aplastic anemia, GI upset, ulcers. |
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Term
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Definition
NSAID: reversibly inhibit COX.
Antipyretic, analgesic, anti-inflammatory.
Renal damage, fluid retention, aplastic anemia, GI upset, ulcers. |
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Term
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Definition
COX2 inhibitor (only one left on market in US!)
Anti-inflammatory/analgesic. Patients with gastritis/ulcers, bleeding risk.
Increased thrombosis risk. Sulfa allergy. |
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Term
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Definition
aka APAP, Paracetamol, "Tylenol"
Rersible COX inhibitor, mainly in CNS. Inactivated peripherally.
Antipyretic, analgesic, NO ANTI-INFLAMMATORY action. Use to avoid Reye's syndrome in children.
Overdose causes fulminant hepatotoxicity due to glutathione depletion and toxic metabolite formation. Antidote: N-acetylcysteine, regenerates glutathione. |
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Term
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Definition
A bisphosphonate.
Inhibits osteoclast activity; reduces bone resorption, remodeling.
Malignancy associated hypercalcemia, Paget's disease, postmenopause osteoporosis.
Corrosive esophagitis (can't lie down after taking), nausea, diarrhea, rare jaw osteonecrosis. |
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Term
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Definition
A bisphosphonate.
Inhibits osteoclast activity; reduces bone resorption, remodeling.
Malignancy associated hypercalcemia, Paget's disease, postmenopause osteoporosis.
Corrosive esophagitis (can't lie down after taking), nausea, diarrhea, rare jaw osteonecrosis. |
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Term
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Definition
A bisphosphonate.
Inhibits osteoclast activity; reduces bone resorption, remodeling.
Malignancy associated hypercalcemia, Paget's disease, postmenopause osteoporosis.
Corrosive esophagitis (can't lie down after taking), nausea, diarrhea, rare jaw osteonecrosis. |
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Term
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Definition
A bisphosphonate.
Inhibits osteoclast activity; reduces bone resorption, remodeling.
Malignancy associated hypercalcemia, Paget's disease, postmenopause osteoporosis.
Corrosive esophagitis (can't lie down after taking), nausea, diarrhea, rare jaw osteonecrosis. |
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Term
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Definition
A bisphosphonate - only one IV!
Inhibits osteoclast activity; reduces bone resorption, remodeling.
Malignancy associated hypercalcemia, Paget's disease, postmenopause osteoporosis.
IV: avoids esophagitis. Nausea, diarrhea, rare jaw osteonecrosis. |
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Term
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Definition
Stabalizes tubulin, prevents microtubule polymerization, inhibits leukocyte chemotaxis and degranulation.
Acute gout (with NSAIDs)
GI side effects. |
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Term
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Definition
Inhibits uric acid reabsorption in PCT.
Chronic gout treatment.
Inhibits penicillin secretion. Sulfa allergy. |
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Term
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Definition
Inhibits xanthine oxidase, preventing formation of xanthine and uric acid.
Chronic gout treatment. Prevent tumor-lysis associated urate nephropathy.
Raises concentration of azathioprine, 6-MP. |
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Term
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Definition
Recombinant soluble TNF-alpha receptor
RA, psoriasis, ankylosing spondylitis
little toxicity
EtanerCEPT = fake reCEPTor |
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Term
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Definition
TNF-alpha mouse-human chimeric antibody
Chron's, RA, ankylosing spondylitis
Predisposes to latent TB reactivation
INFLIX pain on TNF |
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Term
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Definition
Anti-TNF fully-human synthetic antibody RA, psoriasis, ankylosing spondylitis Reactivation of latent TB risk
(Adam was first HUMAN) |
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