Term
| Asprin (Mechanism, Use, side effects) |
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Definition
| Irreversible inhibition of Cyclooxygenase and reduce TXA2, PGI2, PGE2 levels. Low dose - inhibit platelet agregation. Medium dose - antypyretic/analgesic. High dose - antiinflamatory. Toxicity = GI upset and upper GI bleed, acute renal failure, interstitial nephritis, Reye's syndrome in kids with viral infections. |
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Term
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Definition
| Too much salicylate and Arachidonic acid in blood - metabolic acidosis. Treat with bicarbonate, dialysis |
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Term
| NSAIDs (Mech, Use, Side effects) |
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Definition
| Ibuprofen, naproxen, indomethacin, ketorolac. REVERSIBLE binding of Cox1 and Cox2. Block Prostaglanding synthesis. Used as Antipyretic, analgesic, anti-inflamatory, and Indomethacin is used to close PDA. Side effects = Renal damage, fluid retention, aplastic anemia, GI upset/ulcers. |
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Term
| Celecoxib (Mech, Use, side effects) |
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Definition
| REVERSIBLE Cox2 inhibitor. Affects only Cox1 containing inflamatory and VSMCs. Spares Cox1 containing GI mucosa. Used for pain and inflamation in RA and OA. Side effects are increased risk of thrombosis, SULFA allergy, low incidence of GI bleed/upset/ulcers |
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Term
| Acetaminophen (Mech, Use, Side effects) |
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Definition
| Reversible cyclooxygenase inhibitor. NO anti-inflamatory activity. ONLY IN CNS. No peripheral acitivity. Antipyretic/Analgesic. Used instead of Aprin in Reye's Pts. OD causes hepatotoxicity (need n-acytlcystine to replete glutathione). |
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