Term
Cyclosporine
Mech?
Use?
Tox? |
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Definition
Binds cyclophilins. Complex inhibits calcineurin, prevents IL-2 and IL-2R production, prevents Tcell differentiation/activation
Suppress organ rejection; some autoimmune dz
Viral infections, lymphoma; *nephrotoxic (mannitol diuresis) |
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Term
Tacrolimus
aka?
Mech?
Use?
Tox? |
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Definition
aka FK506
Similar to cyclosporine; binds FK-binding protein, prevents IL-2 and other cytokine secretion
Organ transplants
Significant - nephrotoxic, peripheral neuropathy, HTN, pleural effusion, hyperglycemia |
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Term
Sirolimus
aka?
Mech?
Use?
Tox? |
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Definition
aka Rapamycin
Binds mTOR, inhibits T-cell prolif in response to IL-2
Immunosuppression after kidney trsplt w/ cyclosporine
Hyperlipidemia, thrombocytopenia, leukopenia |
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Term
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Definition
| Mab for IL-2 receptors on activated T-cells |
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Term
Azathioprine
Mech?
Use?
Tox? |
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Definition
Precursor of 6-mercaptopurine; toxic to proliferating lymphocytes
Kidney trsplnt, autoimmune disorders (GN, hemolytic anemia)
Bone marrow suppression. Xanthine oxidase metabolises 6-mp, so allopurinol may increase tox |
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Term
Muromonab-CD3
aka?
Mech?
Use?
Tox? |
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Definition
aka OKT3
Mab to CD3 (epsilon chain) on T cells. Blocks signal transduction.
Kidney trsplt
Cytokine release syndrome, hypersensitivity rxn |
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Term
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Definition
aka recombinant IL-2
Renal cell ca, melanoma |
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Term
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Definition
| Anemias, esp. in renal failure |
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Term
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Definition
aka recombinant G-CSF
bone marrow recovery |
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Term
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Definition
aka recombinant GM-CSF
Bone marrow recovery |
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Term
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Definition
| HBV, HCV, Kaposi's sarcoma, leukemias, melanoma |
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Term
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Definition
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Term
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Definition
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Term
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Definition
aka recombinant IL-11
Thrombocytopenia |
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Term
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Definition
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Term
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Definition
| Antidote for digoxin poisoning |
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Term
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Definition
TNF-alpha mab
Chron's, RA, psoriasis, ankylosing spondylitis
Granulomatous infections - do PPD first |
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Term
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Definition
TNF-alpha mab
Chron's, RA, psoriasis
Granulomatous infxn - check PPD first |
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Term
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Definition
mab to platelet glycoprotein IIB/IIIa
Unstable angina, percutaneous coronary interventions |
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Term
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Definition
aka Herceptin
mab to erb-B2
use for HER-2 expressing breast ca |
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Term
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Definition
mab to CD20
B-cell non-Hodgkin's lymphoma |
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Term
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Definition
Synthetic retinoid; promotes cellular differentiation, immunomodulatory effects, anti-tumor effects
Psoriasis
*has 2-day halflife, but can be metabolized to Etretinate (discontinued drug) which has 120-day halflife and similar effects.
*severe teratogen - must be on contraceptives for at least 2 years! because of Etretinate halflife |
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Term
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Definition
Vitamin D analog
topical treatment of psoriasis |
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