Term
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Definition
Reversible blocker of H2 receptors, decreases parietal cell H+ secretion.
Peptic ulcers, gastritis, GERD.
Potent P450 inhibitor, antiandrogenic (prolactin release, gynecomastia, impotence, decreased libido). Crosses BBB (confusion, dizziness, headaches). Crosses placenta. Decreases renal excretion of creatinine, artificial "drop" in GFR. |
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Term
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Definition
Reversible blocker of H2 receptors, decreases parietal cell H+ secretion.
Peptic ulcers, gastritis, GERD.
Decreases renal excretion of creatinine, artificial "drop" in GFR. |
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Term
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Definition
Reversible blocker of H2 receptors, decreases parietal cell H+ secretion.
Peptic ulcers, gastritis, GERD.
Fewer AEs compared to other H2 blockers. |
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Term
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Definition
Reversible blocker of H2 receptors, decreases parietal cell H+ secretion.
Peptic ulcers, gastritis, GERD.
Fewer AEs compared to other H2 blockers. |
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Term
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Definition
Irreversibly inhibits H/K ATPase in stomach parietal cells, active only in acidic area.
Peptic ulcer, gastrics, Zollinger-Ellison syndrome.
Raises stomach pH, may allow bacteria into GI tract. |
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Term
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Definition
Irreversibly inhibits H/K ATPase in stomach parietal cells, active only in acidic area.
Peptic ulcer, gastrics, Zollinger-Ellison syndrome.
Raises stomach pH, may allow bacteria into GI tract. |
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Term
Bismuth/sulcrafate
Mech
Use |
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Definition
Bind to ulcer base, provide physical protection
Ulcer healing, traveler's diarrhea |
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Term
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Definition
PGE1 analog. Increases secretion of gastric mucous barrier, decreases acid production.
Prevent NSAID peptic ulcers, maintain PDA, induce labor.
CI: pregnancy (abortifacient). Diarrhea. |
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Term
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Definition
Anti-muscarinic, block M1 receptors on ECL cells, and M3 receptors on parietal cells.
Peptic ulcer (rarely used)
Tachycardia, dry mouth, accomodation loss. |
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Term
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Definition
Anti-muscarinic, block M1 receptors on ECL cells, and M3 receptors on parietal cells.
Peptic ulcer (rarely used)
Tachycardia, dry mouth, accomodation loss. |
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Term
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Definition
Somatostatin analog.
Acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors.
Nausea, cramps, steatorrhea. |
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Term
Aluminum hydroxide
Mech
Use
Tox |
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Definition
Antacid.
GERD, peptic ulcer.
Affect drug absorption or urinary excretion. Hypokalemia.
Constipation, hypophosphatemia, proximal muscle weakness, osteodystrophy.
Aluminum = minimum amount of poop. |
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Term
Magnesium hydroxide
mech
use
tox |
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Definition
Antacid.
GERD, peptic ulcer.
Affect drug absorption or urinary excretion. Hypokalemia.
Diarrhea, hyporeflexia, hypotension, cardiac arrest.
Mg = Must go to the bathroom. |
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Term
Calcium carbonate
Mech
Use
Tox |
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Definition
Antacid.
GERD, peptic ulcer.
Affect drug absorption, urinary excretion.
Hypercalcemia, hypokalemia, rebound acid increase, can chelate some drugs (tetracyclines, fluoroquinolones). |
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Term
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Definition
Combo of sulfapyridine (Abx) and 5-aminosalicylic acid (NSAID). Cleaved & activated by colonic bacteria for local delivery.
Ulcerative colitis, Chron's disease.
Malaise, nausea, sulfonamide toxicity, *reversible oligospermia. |
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Term
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Definition
5-HT3 antagonist.
Central-acting antiemetic. Post-op and chemo vomiting.
Headache, constipation. |
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Term
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Definition
D2 receptor antagonist. Increases GI resting tone, contractility, LES tone, motility. No change to colonic transport time.
Gastroparesis: diabetic and post-surg.
Increases Parkinsonian effects. Restlessness, drowsiness, fatigue, depression, nausea, diarrhea. Interacts with digoxin and diabetic agents. CI: small bowel obstruction (increaeses tone!) |
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Term
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Definition
Emetic - alkaloid root poison.
Used in acute poisoning cases - if poison is still in stomach/upper GI, may be possible to reduce exposure using emetic. However, rarely used today.
Lethargy, cardiotoxicity, reduces effectiveness of activated charcoal, antidotes, bowel irrigation. |
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Term
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Definition
Charcoal with high surface area (1g = 500m^2!). Highly absorptive.
Acute poisoning.
Not for acid, alkali, or petroleum poisoning. Can cause pulmonary aspiration. |
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