Term
| What is the most common oncogene abnormality in human tumors? |
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Definition
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Term
| In what cancers is the K-Ras mutation found? |
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Definition
| Colon and pancreas (think Kolon and panKreas)...also lung |
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Term
| In what cancers is the H-Ras mutation found? |
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Definition
| think Hematuria...bladder and kidney tumors |
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Term
| In whar cancers is the N-Ras mutation found? |
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Definition
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Term
| What cell cycle checkpoints is p53 involved in? |
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Definition
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Term
| Associated w/ what cancer? strep bovis |
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Definition
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Term
| Associated w/ what cancer? H.pylori |
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Definition
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Term
| Associated w/ what cancer? schistosoma hematobium |
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Definition
| squamous cell cancer of the bladder |
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Term
| Associated w/ what cancer? Clonarchis sinesis |
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Definition
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Term
| What is the associated neoplasm? Hashimoto's thyroiditis (autoimmune dzs in general) |
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Definition
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Term
| What is the associated neoplasm? Down's Syndrome |
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Definition
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Term
| What is the associated neoplasm? Plummer-Vinson syndrome |
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Definition
| Squamous cell carcinoma of the esophagus |
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Term
| What is the associated neoplasm? Tuberous sclerosis |
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Definition
| CARDIAC RHABDOMYOMAS; also astrocytomas and angiomyolipomas |
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Term
| What is the associated neoplasm? Ataxia-Telangiectasia (2) |
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Definition
| Lymphomas and acute leukemias |
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Term
| What is the associated neoplasm? Paget's Dz of bone (2) |
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Definition
| OSTEOSARCOMA, also fibrosarcoma |
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Term
| What is the associated neoplasm? Xeroderma pigmentosum, albinism (3) |
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Definition
| Melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin |
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Term
| What is the associated neoplasm? Barrett's esophagus (chronic GERD) |
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Definition
| Esophageal adenocarcinoma |
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Term
| What is the associated neoplasm? Dysplastic nevus |
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Definition
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Term
| What is the associated neoplasm? Radiation exposure(2) |
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Definition
1. sarcoma
2. papillary thyroid cancer |
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Term
| What is the associated neoplasm? Sjogrens |
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Definition
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Term
| What is the associated neoplasm? Achalasia |
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Definition
| Squamous cell cancer of the esophagus |
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Term
| What cancer has the highest mortality rate in men? |
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Definition
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Term
| What is the most common cancer in women? |
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Definition
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Term
| What associated cancer (tumor suppressor gene)? Rb (2) |
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Definition
| retinoblastoma and osteosarcoma |
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Term
| What associated cancer (tumor suppressor gene)? DPC |
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Definition
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Term
| What associated cancer (tumor suppressor gene)? p53 |
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Definition
| Li Fraumeni syndrome...many cancers |
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Term
| What associated cancer (tumor suppressor gene)? APC |
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Definition
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Term
| What associated cancer (tumor suppressor gene)? WT1 |
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Definition
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Term
| What associated cancer (tumor suppressor gene)? BRCA1 and BRCA2 (2) |
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Definition
| breast and ovarian cancer |
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Term
| What's the associated neoplasm? nitrosamines (2) |
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Definition
| Esophageal and stomach cancer |
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Term
| What's the associated neoplasm? Asbestos |
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Definition
| Lung (mesothelioma and bronchogenic carcinoma) |
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Term
| What's the associated neoplasm? napthalene (aniline dyes)...textile mills, mothballs |
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Definition
| transitional cell carcinoma of the bladder |
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Term
| What's the associated neoplasm? arsenic (2) |
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Definition
| Squamous cell carcinoma of the skin and liver angiosarcoma |
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Term
| What's the associated neoplasm? EBV (4) |
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Definition
1. Burkitt's lymphoma
2. nasopharyngeal carcinoma
3. Hodgkin's lymphoma
4. oral hairy leukoplakia |
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Term
| What's the associated neoplasm? HPV (4) |
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Definition
| Cervical, penile, rectal, vulvar carcinoma |
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Term
| What's the associated neoplasm? schistoma hematobium |
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Definition
| squamous cell cancer of the bladder |
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Term
| What's the associated neoplasm? HBV, HCV |
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Definition
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Term
| What's the associated neoplasm? Aflatoxins |
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Definition
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Term
| What's the associated neoplasm? vinyl chloride |
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Definition
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Term
| What's the associated neoplasm? CCl4 (drycleaning) |
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Definition
| Liver (centrilobular necrosis, fatty change) |
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Term
| What's the associated neoplasm? radon |
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Definition
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Term
| Tumor marker for what cancer? Alpha-fetoprotein (AFP) |
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Definition
| Hepatocellular carcinoma(hep B and C pts) |
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Term
| Tumor marker for what cancer? CA-125 |
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Definition
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Term
| Tumor marker for what cancer? CA-19-9 |
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Definition
| pancreatic adenocarcinoma |
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Term
| Tumor marker for what cancer? S-100 (2) |
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Definition
| melanoma and astrocytomas |
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Term
| Tumor marker for what cancer? CEA |
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Definition
| GI tumors and breast, used more for following the cancer than screening |
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Term
| Tumor marker for what cancer? Bombesin |
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Definition
| Adrenal neuroblastoma, lung and gastric |
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Term
| Which neoplasm(s) cause the paraneoplastic syndrome? Cushing's syndrome |
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Definition
| Small cell lung carcinoma (increased ACTH) |
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Term
| Which neoplasm(s) cause the paraneoplastic syndrome? SIADH |
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Definition
| Small cell lung carcinoma and intracranial neoplasms (increased ADH) |
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Term
| Which neoplasm(s) cause the paraneoplastic syndrome? increased PTH-related peptide leading to hypercalcemia |
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Definition
| Squamous cell lung cancer, Renal cell carcinoma, breast carcinoma |
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Term
| Which neoplasm(s) cause the paraneoplastic syndrome? increased erythropoietin / polycythemia |
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Definition
| Renal cell carcinoma, hemangioblastoma, pheochromocytoma, and hepatocellular carcinoma |
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Term
| Which neoplasm(s) cause the paraneoplastic syndrome? Lambert-Eaton Syndrome |
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Definition
| Thymoma, small cell lung carcinoma(abs against presynaptic Ca2+ channels at NMJ) |
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Term
| Which neoplasm(s) cause the paraneoplastic syndrome? Hyperuricemia |
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Definition
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Term
| Name 3 paraneoplastic syndromes associated w/ small cell lung carcinoma |
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Definition
1. Cushing's syndrome (high ACTH)
2. SIADH (high ADH)
3. Lambert-Eaton Syndrome |
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Term
| Name 2 paraneoplastic syndromes associated with renal cell carcinoma |
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Definition
1. hypErcalcemia (increased PTH-related peptide)
2. Polycythemia due to increased erythropoietin |
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Term
| What paraneoplastic syndrome is associated with squamous cell carcinoma? |
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Definition
| Hypercalcemia due to increased PTH-related peptide |
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Term
| What 4 conditions are psammoma bodies found in? |
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Definition
PSaMMoma:
1. Papillary thyroid
2. Serous cystadenocarcinoma of ovary
3. Meningioma
4. Mesothelioma |
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Term
| Which anticancer drug? forms a complex between topoisomerase II and DNA |
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Definition
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Term
| Which anticancer drug? Alkylates DNA, toxicity=lung fibrosis |
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Definition
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Term
| Which anticancer drug? fragments DNA, toxicity=pulmonary fibrosis |
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Definition
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Term
| Which anticancer drug? blocks purine syntehsis, metabolized by xanthine oxidase |
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Definition
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Term
| Which anticancer drug? crosslinks DNA, nephrotoxic, ototoxic (2) |
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Definition
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Term
| Which anticancer drug? nitrogen mustard, alkylates DNA (electrophile that binds DNA) |
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Definition
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Term
| Which anticancer drug? folic acid analog that inhibits dihydrofolate reductase |
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Definition
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Term
| Which anticancer drug? prevents tubulin disassembly |
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Definition
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Term
| Which anticancer drug? intercalates DNA, producing oxygen free radicals, cardiotoxic (2) |
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Definition
| doxorubicin and danorubicin |
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Term
| Which anticancer drug? prevents tubulin assembly |
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Definition
| vincristine and vinblastine |
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Term
| Which anticancer drug? inhibits thymidylate synthase |
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Definition
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Term
| Which anticancer drug? SERM-blocks estrogen binding to ER-positive cells (2) |
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Definition
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Term
| Which anticancer drug? mechanism is similar to antivrals acyclovir and foscarnet |
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Definition
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Term
| Which anticancer drug? DNA alkylating agents used in brain cancer |
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Definition
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Term
| Which anticancer drug? mechanism is similar to fluoroquinolones |
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Definition
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Term
| Which anticancer drug? mechanism is similar to trimethoprim |
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Definition
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Term
| Which anticancer drug? monoclonal antibody against HER-2 (erb-B2) |
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Definition
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Term
| Which anticancer drug? free radical induced strand breakage (3) |
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Definition
| bleomycin, doxorubicin, danorubacin |
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Term
| Which anticancer drug? inhibitor of PRPP synthetase |
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Definition
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Term
| Which anticancer drug? reversible with leukovorin |
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Definition
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Term
| Which anticancer drug? Treatment for choriocarcinoma (3) |
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Definition
| methotrexate, vincristine, and vinblastine |
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Term
| Which anticancer drug? treatment for AML |
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Definition
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Term
| Which anticancer drug? CML (3) |
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Definition
"H-I Bell (Philadelphia)
hydroxyurea, imatinib (gleevac), busulfan |
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Term
| Which anticancer drug? Treatment for testicular cancer |
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Definition
| "Eliminates Ball Cancer"...Etoposide, Bleomycin, Cisplatin |
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Term
| Which anticancer drug? Applied topically for actinic keratosis and Basal cell cancers |
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Definition
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Term
| Which anticancer drug? Treatment for childhood cancers (Ewing's sarcoma, Wilm's tumor, rhabdomyosarcoma) |
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Definition
| "kids ACT out"...dACTomycin |
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Term
| Which anticancer drug? Inhibits ribonucleotide reductase |
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Definition
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Term
| Which anticancer drug? SE is hemorrhagic cystitis |
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Definition
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Term
| Which anticancer drug? Antibody against the Philadelphia chromosome |
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Definition
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Term
| What is the "rescue" agent for 5-FU? |
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Definition
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Term
| What drug increases the toxicity of 6-mercaptopurine? |
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Definition
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Term
| Which 2 antitumor drugs are cardiotoxic? |
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Definition
| doxorubicin and danorubicin |
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Term
| What can you use to help prevent hemorrhagic cystitis caused by cyclophosphamide? |
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Definition
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Term
| Which anticancer drug is notorious for being neurotoxic? |
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Definition
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Term
| What are signet ring cells seen in the ovary indicative of? |
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Definition
| Kruckenberg's tumor (adenocarcinoma spread to the ovaries) |
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Term
| What is the most common malignant primary bone tumor in kids? |
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Definition
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Term
| What is the most common benign bone tumor? |
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Definition
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Term
| Which primary bone tumor has a "soap-bubble" appearance on x-ray? |
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Definition
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Term
| Cancer metastasis to which lymph nodes? Stomach cancer |
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Definition
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Term
| Cancer metastasis to which lymph nodes? duodenum, jejunum |
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Definition
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Term
| Cancer metastasis to which lymph nodes? sigmoid colon |
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Definition
| Colic-->Inferior Mesenteric |
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Term
| Cancer metastasis to which lymph nodes? Rectum |
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Definition
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Term
| Cancer metastasis to which lymph nodes? Testes |
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Definition
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|
Term
| Cancer metastasis to which lymph nodes? scrotum |
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Definition
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