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USF Pharm Exam #1
General Intro, Diseases, Meds: Anti -biotics, fungals, virals; CNS drugs
74
Pharmacology
Undergraduate 3
09/21/2010

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Term
BBB - Blood Brain Barrier
Definition
-prevents protein bound and ionized drugs from entering the CNS
- passage limited to drugs that are lipid-soluble or have a specific transport mechanism
- not fully developed at birth
Term
Parkinsons' Disease
Definition
- neurodegenerative disroger in which there is a loss of dopaminergic neurons in the substancia nigra in the brain.
- disorder of the extrapyramidal system that regulates movement
Term
Parkinsons' Symptoms
Definition
Tremor, rigidity, instability, slow movement. Can progress to akinesia - no movement, dementia, depresion and memory loss.
Term
Parkinsons' Disease Pathophysiology
Definition
There is an imblanace between ACh, Dopamine, and GABA. GABA is typically an inhibitory NT - it is inhibited by dopamine and stimulated by ACh. Thus, when the dopaminergic neurons are destroyed there is a lack of dopamine to inhibit the GABA, resulting in overstimulation and excessive movement
Term
Lewy Bodies
Definition
Found in autopsy in Parkinsons' patients. Neurotoxic fibrils made of a-synuclein (protein made by dopamergenic neurons) that accumulate in the brain
Term
Drugs to treat Parkinsons
Definition
Levodopa (w. or w/o Carbidopa), Dopamine Agonists, COMT inhibitors, Selegiline, anti-cholergenics
Term
Levodopa-Carbidopa
Definition
Sinemet. Promotes the synthesis of dopamine. Carbidopa increases the effects to the CNS by inhibiting decarboxylation in the intestine.
Term
Levodopa-Carbidopa Side Effects
Definition
Dose-dependent.
N/V
Dykinesis
Increase in BP
psychosis - 20%!
Term
Dopamine Agonists
Definition
FIRST LINE TREATMENT FOR mild to moderate PARKINSONS. Stimulates the dopamine receptors. Less effective but safer, easier than Levo/Carb
Term
COMT inhibitors
Definition
Inhibit metabolism of Levodopa in intestine and peripheral tissues to increase duration between doses and increase therapeutic effects.
Term
Selegine
Definition
MAO-B inhibit that is used with Levo-dopa to reduce "wearing off" effect
Term
Anti-cholinergics
Definition
Relieve Parkinsons by blocking the cholinergic receptors, thus equalizing the imbalance between Dopamine and ACh.
Term
Alzheimers' Disease
Definition
Neural degenerative disorder that begins in the hippocampus and moves into the cerebral cortex.
Marked by a degernation of cholinergic receptors, neuritic plaques, and neurofibril tangles
Term
B-amyloid/ Neuritic Plaques
Definition
In brain, mainly hippocampus and cerebral cortex. Plaques kill cell by disrupting K+ channels, releasing free radicals, and disrupting blood vessels
Term
Alzheimers' Symptoms
Definition
confusion in familiar settings, memory loss, change in personality, judgment.
70-80% have behavior issues.
Term
Alzheimers' Symptoms
Definition
confusion in familiar settings, memory loss, change in personality, judgment.
70-80% have behavior issues.
Term
Drug Therapy for Alzheimers
Definition
- only slows the disease course by a couple months with a small chance of brief improvement
- Cholinerterase Inhibitors
- NMDA-receptor antagonist
- Vit E/Selegine
- NSAIDS
Term
Cholinerterase Inhibitors
Definition
- Donezepil
- prevent breakdown of ACh by ACH-ase in order to allow more ACh for receptors.
Term
Adverse Effects of Cholinerterase Inhibitors
Definition
GI effects, bronchoconstriction r/t increased ACh @ lungs
Term
NMDA receptor antagonists
Definition
Memantine. Treats symptoms with less negative effects and modest benefits.
DECREASED OVERSTIMUATION OF NEURONS B"Y GLUTAMATE. Adv. rxns : dizziness, sedation
Term
NSAIDS (for Alzheimers')
Definition
No good for treatment, but may be preventative. Decrease risk by 80%.,
Term
Multiple Sclerosis (M/S)
Definition
- Immune attack of CNS myelin sheaths.
Term
M/S Signs and Symptoms
Definition
parethesias - numbness and tingling, muscle-motor problems, visual impairment
Term
Drug Therapy of M/S
Definition
1. Immunosuppressants and Immunomodulators - modify disease process by decreasing frequency and severity of relapses.
2. Glucocorticoid Steroids - treat acute relapses by decreasing inflammation, duration and severity
Term
"ABC" drugs - Avonex, Betaseron, Copaxone
Definition
Immunomodulators/suppressants for M/S
Interferon-a, B - rxns: flu-like symptoms, hepatotoxicity, immune suppression, injection site reactions
Copaxone - increases number of anti-inflammatory cells. rxn: itchy, rash. inj. sit rxn.
Term
Corticosteroids
Definition
Methylprednisone. Used for M/S exacerbation to decrease inflammation and supress immune system.
Cushing-like adv. rxns.
Term
Epilepsy Pathophysiology
Definition
- caused by focus - a group of high frequency discharge from hyperexcited neuron
- congential, hypoxia @ birth, head trauma, cancer
Term
Antiepileptic Drugs
Definition
1) suppress discharge of focus
2) suppress focus from spreading to other areas of the brain
- By: suppressing NA, CA, glutamate
increasing GABA to inhibit excitability
- Phenobarbital (oldschool)
- ... newer, better tolerated
Term
Convulsive Status epilepticus
Definition
Tonic-clonic seizure > 30 mins.
=> tachycardia, high BP,
goal of trtmt: terminate seizure, maintain ventilation, correct hypoglycemia.

DRUG: Epinephrine
Term
Pencillins - PCN, Amoxicillin, Augmentin
Definition
Target GRAM POSITIVE BACTERIA
CIDAL - inhibits the bacterial cell wall
Preg B
Excreted via kidneys
Adv. Rxns: ALLERGY, superinfection
Term
Cepalosporin - cefemine, cefe...
Definition
GRAM NEGATIVE BACTERIA, the new 4th generation is BROAD SPECTRUM
CIDAL by inhibiting bact. cell wall.
Preg B.
Excreted via kidneys.
Risk of allergy , superinfection.
10% CROSS ALLERGY WITH PCN
Term
Vancomycin
Definition
GRAM NEGATIVE BACTERIA
CIDAL by inhibiting cell wall
Excreted by kids
MRSA FIRST LINE DRUG
C-DIFF SECOND LINE - only PO use
Adv. Rxn: Otoxicity, Nephrotoxicitiy, Red-man syndrome, phlebitis
Term
Otoxicity
Definition
Damage to CN8 - acoustic (cochlear-vestibular). Damage to hearing, balance. Dizziness.
Term
Tetracycline - doxycycline
Definition
BROAD SPECTRUM - ricksettias, chylamydias, pnuemonias, community aquired MRSA, Lyme Disease.
STATIC by inhibiting protein synthesis.
Excreted by KIDNEY.
Adv. Rxn: GI upset, photosensitivity, superinfection
- GIVE ON EMPTY STOMACH - chelated by Fe, Mg, Ca, Al.
CONTRAINDICATED IN PREGNANCY: X
Term
Macrolides (Clindamycin, Linezoid)
Definition
BROAD SPECTRUM
CIDAL by inhibiting protein synthesis
Preg B/C. Excreted by liver.
Adv. Rxn: GI upset, inhibits metabolism of other drugs via site competition
- FIRST LINE COM. Acq. PNEUMONIA
- Used for staph/strep in PCN-allergic
- Administer IV over 1 hr
- Administer probiotics to prevent superinfection
Term
Nephrotoxicity
Definition
Damage to kidneys by drugs.
Monitored by keeping eye on kidney function - BUN, CR Clearance lab tests
Term
Aminoglycosides - Gentamycin, Tobramycin, Amakin
Definition
GRAM NEGATIVE BACTERIA
CIDAL by inhibiting protein synthesis
PREG CLASS D
Excreted by KIDNEYS
Adv. Rxns: Ototoxicity, neuromuscular block
Term
Sulfa
Definition
Term
Sulfa
Definition
BROAD SPECTRUM for UTI, pneumocystisis
STATIC by inhibiting bacteria synthesis of folic acid
PREG: X
Metabolized by LIVER, excreted via KIDNEY
Adv. Rxn: rash, photosensitivity, Stevens-Johnson syndrome, kernicterus, rare hemolytic anemia.
INHIBITS METABOLISM OF WARFARIN
Term
Metronidazole
Definition
ANAEROBIC BACTERIA, PROTOZOA, GIARDIASIS,
CIDAL by DAMAGING Bacteria DNA
LIVER metabolism, KIDNEY excretion
Adv. Rxn: Disulfrum-like rxn with alcohol - n/v. H/A.
INCREASES EFFECT OF WARFARIN, PHENYTOIN

FIRST LINE FOR C. DIFF
Term
Floroquinolones
Definition
BROAD SPECTRUM - most effacious.
CIDAL by inhibiting DNA gyrase
PREGNANCY X
Hepatic metabolism. Excreted in stool/urine.
Adv. Rxn: GI upset, CNS effect, tendone rupture, superinfection
- chelated by Fe, Ca, Mg, Al
Term
Nitrofurantoin
Definition
UTI, E.coli
Metabolized by LIVER, excreted by KIDNEY
Adv. Rxns: GI upset, blood dyscrasia, hemolytic anemia, neuropathy
- * URINE TURNS BROWN
- Psuedomonias, Klebsettia, Proteus are insensitive.
Term
Ampotercin B
Definition
SYSTEMIC FUNGAL INFECTION
Adv. Rxn: nephtotoxicity, infusion rxns
"shake and bake" - chills and sweats.
* Premedicate with tylenol, benadryl
Term
Azoles
Definition
Fungals. TOPICAL for skin/vag
Adv. Rxn: hepatotoxic when PO, IV
- Inhibits metabolism of other drugs
Term
Nystatin
Definition
USED OF ORAL/CUTANEOUS THRUSH
Term
Terbafin (Lamasil)
Definition
Oral: onchomycosis
Topical: tinea
Adv. Rsn: hepatotoxicity
- Avoid alcohol
Term
Acyclovir
(valacyclovir, famicyclovir)
Definition
- TREATS HPV
Adv. rxns: N/V, diarrhea, vertigo
nephrotoxic
*Most effective at first sign of herpes
Term
Zostavax
Definition
Vaccine for Herpes Zoster
Can cause live virus in immunocompromised patients
Term
Interferon - a
Definition
CHRONIC HEPATITIS B, C
Blocks viral entry into cells, and RNA synthesis.
Adv. rxn: flu-like symptoms, depression, inj. site rxn
- SUBQ INJ
Term
Oseltamivir
Definition
INFLUENZA VIRUS
Inhibits virus enzyme for replication
Term
Oseltamivir
Definition
INFLUENZA VIRUS
Inhibits virus enzyme for replication
Adv. Rxn: N/V
- most effective within 12 hours of starting to feel ill
- decreases severity, durtation
- give with food
Term
Isonizid, Rifampin, Pyramizade, Ethambutol
Definition
TREATS TB
Adv. Rxn: Nephrotoxictiy
Rifampin turns body fluids ORANGE
Monitor vision with ethambutol
Excreted RENALLY
Term
TB Diagnosis
Definition
-PPD - preliminary skin screening
- Chest X-ray
- Acid-fast bacilli in sputum
- Culture (takes weeks)
Term
Chylamydia (trachomatis) symptoms
Definition
non-gonococcal urethritis in males, asymptomatic women. eye infection in babies
Term
Chlamydia treatment
Definition
1 DOSE Azithromycin or 7day Doxycycline
Term
LGV - lymphogranuloma vererum
Definition
Doxycycline 21 days
Symptomgs: gential erosion, lymphatic swelling and obstruction
NEW: SOME CASES IN SOUTHERN US
Term
Gonorrhea
Definition
TRTMT: Ceftriaxone, Ceftixime.
Symptoms: Male- mucopurulent urethritis.
Women - asymptomatic until PID, mucopurulent cervitis.

CAN LEAD TO SEPSIS, SKIN LESIONS, ARTHRITIS

CAN CAUSE BLINDESS IN UNTREATED INFANTS
Term
Gonorrhea
Definition
TRTMT: Ceftriaxone, Ceftixime.
Symptoms: Male- mucopurulent urethritis.
Women - asymptomatic until PID, mucopurulent cervitis.

CAN LEAD TO SEPSIS, SKIN LESIONS, ARTHRITIS

CAN CAUSE BLINDESS IN UNTREATED INFANTS
Term
Adverse Effects of Levodopa/Carbidopa
Definition
Dopamine Excess: N/V, spastic dyskinesias, orthostatic hypotension, psychosis
Term
Adverse reactions of Anti-cholergenic drugs (Benzotropine)
Definition
- Anticholinergic effects: Increased HR, BP, decreased GI motility
constipation, urine retention, dry mouth, dilated pupils
TREATS PARKINSON TREMOR as supplement to Dopamine Agonists or Levo/Carb
Term
Cholinesterase Inhibitors
Definition
INCREASES AVAILABLE ACH
Adv. Rxn: Cholinergic - increased GI motitlty, lowerd HR. N/V/D, anorexia, bradycardia --> fainting.

REALISTIC EXPECTATIONS OF EFFECTS ON ALZHEIMERS!
Term
Interferon- B
Definition
M/S - inhibits inflammatory WBC from entering CNS and attacking myelin. Immunomodulator.

Adv. Rxn: flu-like symptoms, hepatoxicitiy, bone marrow suppression, inj. site rxn, depression.
DECREASES EXACERBATIONS

NEEDS AST, ALT, CBC Tests
Term
Bone marrow suppression
Definition
must be monitored with CBC test to count RBC/WBC
Term
Hepatotoxicity
Definition
Liver damage. Monitor function via AST, ALT lab tests
Term
Anticonvulsants
Definition
INDICATIONS: Seizure, Bipolar Mgmt, Migraines, Neuropathic pain.
Works by closing Na, Ca channels and increasing inhibitory GABA
- HAVE NARROW THERAPEUTIC INDEXES
Term
Phenytoin - Dilantin
Definition
Anticonvulsant. closes Na channels.
Adv. Rxns: CNS suppression, gingival hyperplasia, skin rash - can turn into Stevens-Johnson syndrome
INDUCES METABOLISM OF OTHER DRUGS, lower efficacy.
THERAPEUTIC RANGE: 10-30 mcg/mL
-Must be diluted in saline
-Drug levels must be lab tests
Term
THERAPEUTIC RANGE OF PHENYTOIN -DILANTIN
Definition
10-20 mcg/mL
Term
Carbamazepine (Tegretol)
Definition
Seizure ctrl, bipolar, trigeminal neuralgia. Closes NA channels.
Adv. Rxn: CNS depression, bone marrow depression, Stevens-Johnson syndrome with increased risk in Asians with HLA-B1502 gene.
INDUCES METABOLISM OF OTHER DRUGS, lowering efficacy.
Test CBC and blood drug levels.
THERAPEUTIC RANGE - 4-13 mcg/mL
Term
IV Ativan, Benzodiazapine, Corzepam
Definition
Tranquilize to stop status epilepticus seizures.
CAN CAUSE RABDMYLOLYSIS - blockage of kidney with proteins from dead cells.
Term
Valproic Avid - Depakote
Definition
MOOD STABILIZER OF CHOICE FOR BIPOLAR. Also, seizure ctrl, migraine prevention. Closes NA, CA channels and increases inhibitory GABA.
Adv. Rxns: CNS DEPRESSION, hepatotoxicity, pancreatitis, hair loss, temeor, bone marrow suppression.

THERAPEUTIC RANGE OF VALPROIC ACID: 40-100 mcg/mL.

CBC, ALT, AST, drug levels must be tested
Term
THERAPEUTIC RANGE OF VALPROIC ACID - DEPAKOTE
Definition
40-100 mcg/mL
Term
THERAPEUTIC RANGE OF CARBZMAZEPINE - TEGRETOL
Definition
4- 12 mcg/mL
Term
Gabapentin - neurotonin
Definition
Neuropathic pain. Increases GABA.
Can cause CNS depression.
Term
Levetiracetar - KEPPRA
Definition
SEIZURE CONTROL MED OF CHOICE
Unknown MOA.
Can cause sedation but not a narrow therapeutic range drug AND no sig interactions with other drugs.
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